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Carf
Gene Detail
Symbol

Name
ID
Carf
calcium response factor
MGI:2182269
Synonyms
Als2cr8
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:60098247-60153953 bp, + strand
From VEGA annotation of GRCm38

  55707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CARF
Gene Tree: Carf

Human
homologs
CARF, calcium responsive transcription factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79800
neXtProt AC: NX_Q8N187

Human Synonyms: ALS2CR8, NYD-SP24

Human Chr (Location): 2q33.2; chr2:202912218-202987857 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have aberrant learning and memory.
 
Interactions
Carf interacts with 79 markers (Mir7-1, Mir10a, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to calcium ion, cellular response to potassium ion, ...
Component nucleolus, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase carf    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000022350 (Evidence)
Ensembl Gene Model ENSMUSG00000026017 (Evidence)
Entrez Gene 241066 (Evidence)
DFCI TC1690756, TC1589621, TC1626595, TC1612991
DoTS DT.55109880, DT.40149068, DT.91397120, DT.97408209
NIA Mouse Gene Index U144708, U000334
Consensus CDS Project CCDS14989.1
International Mouse Phenotyping Consortium Status Carf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022350 VEGA Gene Model | MGI Sequence Detail 55707 C57BL/6J ±  kb
transcript OTTMUST00000053331 VEGA | MGI Sequence Detail 5463 Not Applicable 
polypeptide OTTMUSP00000025362 VEGA | MGI Sequence Detail 689 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(31) UniProt(6)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000003977 amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
References
(Earliest) J:76631 Tao X, et al., A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383-95
(Latest) J:213372 Agostino PV, et al., Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes Brain Behav. 2013 Aug;12(6):633-44
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory