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Carf
Gene Detail
Symbol

Name
ID
Carf
calcium response factor
MGI:2182269
Synonyms
Als2cr8
Feature Type
protein coding gene
Genetic Map
Chromosome 1
30.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:60098247-60153953 bp, + strand
From VEGA annotation of GRCm38

  55707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Carf

Human
homologs
Human Homolog CARF, calcium responsive transcription factor
NCBI Gene ID 79800
neXtProt AC  NX_Q8N187
Human Synonyms  ALS2CR8, NYD-SP24
Human Chr (Location)  2q33.2; chr2:202912218-202986485 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have aberrant learning and memory.
 
Interactions
Carf interacts with 79 markers (Mir7-1, Mir10a, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to calcium ion, cellular response to potassium ion, ...
Component nucleolus, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000022350 (Evidence)
Ensembl Gene ModelENSMUSG00000026017 (Evidence)
Entrez Gene241066 (Evidence)
DFCITC1690756, TC1626595, TC1612991, TC1589621
DoTSDT.97408209, DT.91397120, DT.55109880, DT.40149068
NIA Mouse Gene IndexU144708, U000334
Consensus CDS ProjectCCDS14989.1
International Mouse Knockout Project StatusCarf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022350 VEGA Gene Model | MGI Sequence Detail 55707 C57BL/6J ±  kb
transcript OTTMUST00000053331 VEGA | MGI Sequence Detail 5463 Not Applicable 
polypeptide OTTMUSP00000025362 VEGA | MGI Sequence Detail 689 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(24) UniProt(10)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000003977 amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
References
(Earliest) J:76631 Tao X, et al., A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383-95
(Latest) J:213372 Agostino PV, et al., Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes Brain Behav. 2013 Aug;12(6):633-44
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory