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Carf Gene Detail
Summary
  • Symbol
    Carf
  • Name
    calcium response factor
  • Synonyms
    Als2cr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182269
    NCBI Gene: 241066
  • Gene Overview
    MyGene.info: CARF
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:60098247-60153953 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182269
protein coding gene Chr1:60098221-60153953 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016074
protein coding gene Chr1:60157891-60217007 (+)
A/J MGP_AJ_G0016057
protein coding gene Chr1:58020120-58078606 (+)
AKR/J MGP_AKRJ_G0016013
protein coding gene Chr1:59671280-59725546 (+)
BALB/cJ MGP_BALBcJ_G0016012
protein coding gene Chr1:58052359-58111974 (+)
C3H/HeJ MGP_C3HHeJ_G0015844
protein coding gene Chr1:59904030-59958723 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016465
protein coding gene Chr1:62479019-62537014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014186
protein coding gene Chr1:54221585-54277769 (+)
CAST/EiJ MGP_CASTEiJ_G0015426
protein coding gene Chr1:59093059-59157814 (+)
CBA/J MGP_CBAJ_G0015816
protein coding gene Chr1:64457095-64538688 (+)
DBA/2J MGP_DBA2J_G0015917
protein coding gene Chr1:57450274-57506574 (+)
FVB/NJ MGP_FVBNJ_G0015919
protein coding gene Chr1:56740598-56797486 (+)
LP/J MGP_LPJ_G0015989
protein coding gene Chr1:61029751-61083458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015939
protein coding gene Chr1:67336513-67400427 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016512
protein coding gene Chr1:59563629-59626769 (+)
PWK/PhJ MGP_PWKPhJ_G0015213
protein coding gene Chr1:56803012-56865021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014993
protein coding gene Chr1:59090374-59154711 (+)
WSB/EiJ MGP_WSBEiJ_G0015489
protein coding gene Chr1:59268494-59327867 (+)



Homology
more
  • Human Ortholog
    CARF, calcium responsive transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CARF, calcium responsive transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS2CR8, NYD-SP24
  • Links
    NCBI Gene ID: 79800
    neXtProt AC: NX_Q8N187
    UniProt: Q8N187

  • Chr Location
    2q33.2; chr2:202912218-202987856 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11689
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CARF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have aberrant learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026017 Ensembl Gene Model | MGI Sequence Detail 55707 C57BL/6J ±  kb
transcript ENSMUST00000187978 Ensembl | MGI Sequence Detail 5463 Not Applicable  
polypeptide ENSMUSP00000141169 Ensembl | MGI Sequence Detail 689 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 2
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory