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Lrrc4 Gene Detail
Summary
  • Symbol
    Lrrc4
  • Name
    leucine rich repeat containing 4
  • Synonyms
    Nag14, NGL2, NGL-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182081
    NCBI Gene: 192198
  • Gene Overview
    MyGene.info: LRRC4
Location & Maps
more
  • Sequence Map
    Chr6:28661831-28831747 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      169917 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LRRC4, leucine rich repeat containing 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRRC4, leucine rich repeat containing 4
    Orthology source: HomoloGene
  • Synonyms
    NAG14, NGL-2
  • Links
    NCBI Gene ID: 64101
    neXtProt AC: NX_Q9HBW1

  • Chr Location
    7q31.3; chr7:128027071-128032107 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperactivity, an absence of startle reflex, and abnormal ABR amplitude.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023270 VEGA Gene Model | MGI Sequence Detail 169917 C57BL/6J ±  kb
transcript OTTMUST00000056337 VEGA | MGI Sequence Detail 3615 Not Applicable  
polypeptide OTTMUSP00000027065 VEGA | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1261 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030397 leucine-rich repeat-containing protein 4
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR026882 Leucine-rich repeat-containing protein 4
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 8
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:112175 Lin JC, et al., The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nat Neurosci. 2003 Dec;6(12):1270-6
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory