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Odf4 Gene Detail
Summary
  • Symbol
    Odf4
  • Name
    outer dense fiber of sperm tails 4
  • Synonyms
    Oppo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182079
    NCBI Gene: 252868
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68812661-68817907 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182079
protein coding gene Chr11:68812661-68817907 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018508
protein coding gene Chr11:69307381-69313587 (-)
A/J MGP_AJ_G0018477
protein coding gene Chr11:66709783-66715741 (-)
AKR/J MGP_AKRJ_G0018446
protein coding gene Chr11:68704316-68711670 (-)
BALB/cJ MGP_BALBcJ_G0018448
protein coding gene Chr11:67003167-67017139 (-)
C3H/HeJ MGP_C3HHeJ_G0018261
protein coding gene Chr11:68719917-68727830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018900
protein coding gene Chr11:71415987-71422619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016544
protein coding gene Chr11:63646570-63652190 (-)
CAST/EiJ MGP_CASTEiJ_G0017817
protein coding gene Chr11:68956643-68964174 (-)
CBA/J MGP_CBAJ_G0018235
protein coding gene Chr11:74594302-74612159 (-)
DBA/2J MGP_DBA2J_G0018344
protein coding gene Chr11:66305277-66310487 (-)
FVB/NJ MGP_FVBNJ_G0018334
protein coding gene Chr11:65926977-65932384 (-)
LP/J MGP_LPJ_G0018415
protein coding gene Chr11:69890275-69897221 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018357
protein coding gene Chr11:75266331-75272099 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018941
protein coding gene Chr11:68946482-68951638 (-)
PWK/PhJ MGP_PWKPhJ_G0017592
protein coding gene Chr11:66934992-66940494 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017380
protein coding gene Chr11:68784091-68789356 (-)
WSB/EiJ MGP_WSBEiJ_G0017870
protein coding gene Chr11:68585385-68591749 (-)



Homology
more
  • Human Ortholog
    ODF4, outer dense fiber of sperm tails 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ODF4, outer dense fiber of sperm tails 4
  • Synonyms
    CT134, CT136, OPPO1
  • Links
    NCBI Gene ID: 146852
    neXtProt AC: NX_Q2M2E3
    UniProt: Q2M2E3

  • Chr Location
    17p13.1; chr17:8339840-8346048 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit severely reduced male fertility with oligozoospermia and asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 252868 NCBI Gene Model | MGI Sequence Detail 5247 C57BL/6J ±  kb
    transcript NM_145746 RefSeq | MGI Sequence Detail 1289 Not Specified  
    polypeptide Q8VI88 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:333391 Ito C, et al., The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape. Sci Rep. 2023;13(1):2969

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory