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Usp7 Gene Detail
Summary
  • Symbol
    Usp7
  • Name
    ubiquitin specific peptidase 7
  • Synonyms
    2210010O09Rik, Hausp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182061
    NCBI Gene: 252870
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:8506586-8574931 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 4.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182061
 protein coding gene Chr16:8506586-8610172 (-)
129S1/SvImJ ENSMUSG00200010920
 protein coding gene Chr16:5487036-5554511 (-)
A/J ENSMUSG00195011396
 protein coding gene Chr16:5042423-5109431 (-)
AKR/J ENSMUSG00220016835
 protein coding gene Chr16:5331177-5398183 (-)
BALB/cJ ENSMUSG00180007781
 protein coding gene Chr16:5289540-5357021 (-)
C3H/HeJ ENSMUSG00175026470
 protein coding gene Chr16:5480670-5548152 (-)
C57BL/6NJ ENSMUSG00215011573
 protein coding gene Chr16:5154738-5222224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020435
 protein coding gene Chr16:5243578-5349903 (-)
CAST/EiJ ENSTCUG00005027108
 protein coding gene Chr16:5385367-5452276 (-)
CBA/J ENSMUSG00210011457
 protein coding gene Chr16:5497907-5565392 (-)
DBA/2J ENSMUSG00185009929
 protein coding gene Chr16:5443153-5510634 (-)
FVB/NJ ENSMUSG00205009415
 protein coding gene Chr16:5361476-5428965 (-)
JF1/MsJ ENSUMUG00000020095
 protein coding gene Chr16:5520304-5587698 (-)
LP/J ENSMUSG00230009169
 protein coding gene Chr16:7985665-8053136 (-)
NOD/ShiLtJ ENSMUSG00190022808
 protein coding gene Chr16:5534437-5601921 (-)
NZO/HlLtJ ENSMUSG00225030328
 protein coding gene Chr16:11226308-11293792 (-)
PWK/PhJ ENSLUMG00010016650
 protein coding gene Chr16:5351147-5418514 (-)
SPRET/EiJ ENSMSPG00010015753
 protein coding gene Chr16:5331132-5432496 (-)
WSB/EiJ ENSIUOG00005015267
 protein coding gene Chr16:5467493-5534778 (-)



Homology
more
  • Human Ortholog
    USP7, ubiquitin specific peptidase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP7, ubiquitin specific peptidase 7
  • Synonyms
    C16DELp13.2, DEL16P13.2, HAFOUS, HAUSP, TEF1
  • Links
    NCBI Gene ID: 7874
    UniProt: Q93009

  • Chr Location
    16p13.2; chr16:8892097-8975328 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show embryonic growth arrest and die between E6.5 and E7.5. Mice homozygous for a conditional allele activated in neural cells exhibit complete neonatal lethality, absent gastric milk, uncoordinated movement and abnormalforebrain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    16
  • cDNA Data
    16
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 252870 NCBI Gene Model | MGI Sequence Detail 68346 C57BL/6J ±  kb
    transcript NM_001003918 RefSeq | MGI Sequence Detail 5427 C57BL/6  
    polypeptide Q6A4J8 UniProt | EBI | MGI Sequence Detail 1103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000017196 ubiquitin carboxyl-terminal hydrolase 7
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR002083 MATH/TRAF domain
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR008974 TRAF-like
      IPR024729 Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
      IPR029346 Ubiquitin carboxyl-terminal hydrolase, C-terminal
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    • GlyGen
      Q6A4J8 4 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16
      Antibodies 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917314, MGI:2146342, MGI:2146361, MGI:2146552, MGI:2146656, MGI:2146709
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 11
      Gene Ontology 18
      Phenotypes 24
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:389441 Schwarz LA, et al., Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026 Jun 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory