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Mtnr1b Gene Detail
Summary
  • Symbol
    Mtnr1b
  • Name
    melatonin receptor 1B
  • Synonyms
    Mel1b, Mt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181726
    NCBI Gene: 244701
  • Gene Overview
    MyGene.info: MTNR1B
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:15862614-15874556 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 5.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181726
protein coding gene Chr9:15824528-15874556 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034369
protein coding gene Chr9:12825512-12876993 (-)
A/J MGP_AJ_G0034347
protein coding gene Chr9:12758427-12808393 (-)
AKR/J MGP_AKRJ_G0034275
protein coding gene Chr9:12781952-12830830 (-)
BALB/cJ MGP_BALBcJ_G0034341
protein coding gene Chr9:12526071-12578298 (-)
C3H/HeJ MGP_C3HHeJ_G0034052
protein coding gene Chr9:13098813-13144898 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034863
protein coding gene Chr9:13242268-13299911 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031801
protein coding gene Chr9:12004649-12049184 (-)
CAST/EiJ MGP_CASTEiJ_G0033379
protein coding gene Chr9:12958440-13002433 (-)
CBA/J MGP_CBAJ_G0034025
protein coding gene Chr9:13863780-13923848 (-)
DBA/2J MGP_DBA2J_G0034182
protein coding gene Chr9:12606683-12658031 (-)
FVB/NJ MGP_FVBNJ_G0034127
protein coding gene Chr9:12188873-12239866 (-)
LP/J MGP_LPJ_G0034268
protein coding gene Chr9:12931979-13002866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034171
protein coding gene Chr9:14866076-14918086 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034882
protein coding gene Chr9:12819018-12877960 (-)
PWK/PhJ MGP_PWKPhJ_G0033085
protein coding gene Chr9:12697160-12751564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032920
protein coding gene Chr9:12933825-12983541 (-)
WSB/EiJ MGP_WSBEiJ_G0033495
protein coding gene Chr9:12655037-12705406 (-)



Homology
more
  • Human Ortholog
    MTNR1B, melatonin receptor 1B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MTNR1B, melatonin receptor 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGQTL2, MEL-1B-R, MT2
  • Links
    NCBI Gene ID: 4544
    neXtProt AC: NX_P49286
    UniProt: P49286

  • Chr Location
    11q14.3; chr11:92969623-92986241 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MTNR1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and display no obvious circadian phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 244701 NCBI Gene Model | MGI Sequence Detail 11943 C57BL/6J ±  kb
transcript NM_145712 RefSeq | MGI Sequence Detail 1244 C57BL/6  
polypeptide Q8CIQ6 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR027459 Melatonin receptor 1
    IPR000025 Melatonin receptor family
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:76848 Weaver DR, et al., Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov;10(11):1478-87
  • Latest
    J:262608 Clough SJ, et al., Food-induced reinforcement is abrogated by the genetic deletion of the MT1 or MT2 melatonin receptor in C3H/HeN mice. Behav Brain Res. 2018 May 2;343:28-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory