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Mtnr1b
Gene Detail
Symbol

Name
ID
Mtnr1b
melatonin receptor 1B
MGI:2181726
Synonyms
Mel1b, Mt2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
5.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:15824528-15874556 bp, - strand
From VEGA annotation of GRCm38

  50029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: MTNR1B
Protein SuperFamily: MT1-like melatonin receptor
Gene Tree: Mtnr1b

Human
homologs
MTNR1B, melatonin receptor 1B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4544
neXtProt AC: NX_P49286

Human Synonyms: FGQTL2, MEL-1B-R, MT2

Human Chr (Location): 11q21-q22; chr11:92969623-92986240 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MTNR1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile and display no obvious circadian phenotype.
 
Interactions
Mtnr1b interacts with 12 markers (Mir18, Mir18b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process circadian rhythm, glucose homeostasis, ...
Component cytosol, integral component of membrane, ...
Function G-protein coupled receptor activity, melatonin receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN mtnr1ba    NEW 
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000043340 (Evidence)
Ensembl Gene Model ENSMUSG00000050901 (Evidence)
Entrez Gene 244701 (Evidence)
UniGene 222631
DFCI TC1599341
DoTS DT.94147473
Consensus CDS Project CCDS22841.1
International Mouse Phenotyping Consortium Status Mtnr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043340 VEGA Gene Model | MGI Sequence Detail 50029 C57BL/6J ±  kb
transcript OTTMUST00000113700 VEGA | MGI Sequence Detail 1835 Not Applicable 
polypeptide OTTMUSP00000063530 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR027459 Melatonin receptor 1B
InterPro IPR000025 Melatonin receptor family
Protein Ontology PR:000001610 melatonin receptor type 1B
References
(Earliest) J:76848 Weaver DR, et al., Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov;10(11):1478-87
(Latest) J:208005 Corthell JT, et al., Melatonin in the mammalian olfactory bulb. Neuroscience. 2014 Mar 7;261:74-84
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory