Mtnr1b
Gene Detail

Symbol Name ID

Mtnr1b melatonin receptor 1B MGI:2181726

Synonyms

Mel1b, Mt2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

5.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:15862614-15874556 bp, - strand From NCBI annotation of GRCm38   11943 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: MT1-like melatonin receptor
Gene Tree: Mtnr1b

Human homologs

Human Homolog		MTNR1B, melatonin receptor 1B
NCBI Gene ID		4544
neXtProt AC		NX_P49286
Human Synonyms		FGQTL2, MEL-1B-R, MT2
Human Chr (Location)		11q21-q22; chr11:92702789-92715948 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MTNR1B

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele are viable and fertile and display no obvious circadian phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	circadian rhythm, glucose homeostasis, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, melatonin receptor activity, ...

External Resources: FuncBase

Expression

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(3)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000050901 (Evidence)
Entrez Gene	244701 (Evidence)
UniGene	222631
DFCI	TC1599341
DoTS	DT.94147473
Consensus CDS Project	CCDS22841.1
International Mouse Knockout Project Status	Mtnr1b

Sequences

Length	Strain/Species
genomic	244701	NCBI Gene Model | MGI Sequence Detail	11943	C57BL/6J
transcript	NM_145712	RefSeq | MGI Sequence Detail	1244	C57BL/6
polypeptide	Q8CIQ6	UniProt | EBI | MGI Sequence Detail	364	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000025	Melatonin receptor
Protein Ontology	PR:000001610	melatonin receptor 1B

Graphical View of Protein Domain Structure

References

(Earliest) J:76848 Weaver DR, et al., Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov;10(11):1478-87
(Latest) J:193777 Muhlbauer E, et al., Differential and day-time dependent expression of nuclear receptors RORalpha, RORbeta, RORgamma and RXRalpha in the rodent pancreas and islet. Mol Cell Endocrinol. 2013 Jan 30;365(2):129-38
All references(33)