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Mtnr1b
Gene Detail
 Symbol
Name
ID
Mtnr1b
melatonin receptor 1B
MGI:2181726
Synonyms Mel1b, Mt2
Feature Type protein coding gene
Genetic Map
Chromosome 9
5.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:15824528-15874556 bp, - strand
From VEGA annotation of GRCm38

  50029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: MT1-like melatonin receptor
Gene Tree: Mtnr1b

Human
homologs
Human Homolog MTNR1B, melatonin receptor 1B
NCBI Gene ID 4544
neXtProt AC  NX_P49286
Human Synonyms  FGQTL2, MEL-1B-R, MT2
Human Chr (Location)  11q21-q22; chr11:92969623-92982782 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MTNR1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile and display no obvious circadian phenotype.
 
Interactions
Mtnr1b interacts with 12 markers (Mir18, Mir18b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process circadian rhythm, glucose homeostasis, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled receptor activity, melatonin receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000043340 (Evidence)
Ensembl Gene ModelENSMUSG00000050901 (Evidence)
Entrez Gene244701 (Evidence)
UniGene222631
DFCITC1599341
DoTSDT.94147473
Consensus CDS ProjectCCDS22841.1
International Mouse Knockout Project StatusMtnr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043340 VEGA Gene Model | MGI Sequence Detail 50029 C57BL/6J ±  kb
transcript OTTMUST00000113700 VEGA | MGI Sequence Detail 1835 Not Applicable 
polypeptide OTTMUSP00000063530 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR027459 Melatonin receptor 1B
InterPro IPR000025 Melatonin receptor family
Protein Ontology PR:000001610 melatonin receptor type 1B
References (Earliest) J:76848 Weaver DR, et al., Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters. Mol Endocrinol. 1996 Nov;10(11):1478-87
(Latest) J:199952 Bedrosian TA, et al., Evidence for feedback control of pineal melatonin secretion. Neurosci Lett. 2013 May 10;542:123-5
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory