Bbc3
Gene Detail

Symbol Name ID

Bbc3 BCL2 binding component 3 MGI:2181667

Synonyms

PUMA

Feature Type

protein coding gene

Genetic Map

Chromosome 7

8.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:16309616-16318205 bp, + strand From VEGA annotation of GRCm38   8590 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8679  Vertebrate Homology Class
1 mouse; 1 chimpanzee; 1 dog

Gene Tree: Bbc3

Alleles and phenotypes

All alleles(24) : Targeted(4) Gene trapped(20)
 

Mice homozygous for disruptions in this gene display abnormalities in apoptosis but otherwise are phenotypically normal.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	mitochondrial envelope, mitochondrion
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(17)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000022267 (Evidence)
Ensembl Gene Model	ENSMUSG00000002083 (Evidence)
Entrez Gene	170770 (Evidence)
UniGene	7660
DFCI	TC1582159
DoTS	DT.101709737
NIA Mouse Gene Index	U007704
PDB	2ROC, 2VOF
Consensus CDS Project	CCDS20847.1
International Mouse Knockout Project Status	Bbc3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022267	VEGA Gene Model | MGI Sequence Detail	8590	C57BL/6J
transcript	OTTMUST00000053027	VEGA | MGI Sequence Detail	1814	Not Applicable
polypeptide	OTTMUSP00000025190	VEGA | MGI Sequence Detail	193	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000003124	Bcl-2-binding component 3

References

(Earliest) J:76185 Yu J, et al., PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar;7(3):673-82
(Latest) J:192131 Neal MD, et al., Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem. 2012 Oct 26;287(44):37296-308
All references(98)