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Bbc3
Gene Detail
Symbol

Name
ID
Bbc3
BCL2 binding component 3
MGI:2181667
Synonyms
PUMA
Feature Type
protein coding gene
Genetic Map
Chromosome 7
8.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:16309616-16318205 bp, + strand
From VEGA annotation of GRCm38

  8590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Gene Tree: Bbc3

Human
homologs
Human Homolog BBC3, BCL2 binding component 3
NCBI Gene ID 27113
neXtProt AC  NX_Q96PG8, NX_Q9BXH1
Human Synonyms  JFY1, JFY-1, PUMA
Human Chr (Location)  19q13.3-q13.4; chr19:47220822-47232853 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
 
Mice homozygous for disruptions in this gene display abnormalities in apoptosis but otherwise are phenotypically normal.
 
Interactions
Bbc3 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component cytosol, endoplasmic reticulum, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (41)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000022267 (Evidence)
Ensembl Gene ModelENSMUSG00000002083 (Evidence)
Entrez Gene170770 (Evidence)
UniGene7660
DFCITC1582159
DoTSDT.101709737
NIA Mouse Gene IndexU007704
PDB2VOF, 2ROC
Consensus CDS ProjectCCDS20847.1
International Mouse Knockout Project StatusBbc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022267 VEGA Gene Model | MGI Sequence Detail 8590 C57BL/6J ±  kb
transcript OTTMUST00000053027 VEGA | MGI Sequence Detail 1814 Not Applicable 
polypeptide OTTMUSP00000025190 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(22) UniProt(5)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000003124 Bcl-2-binding component 3
References
(Earliest) J:76185 Yu J, et al., PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar;7(3):673-82
(Latest) J:210310 Leibowitz BJ, et al., Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nat Commun. 2014;5:3494
All references(117)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory