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Bbc3
Gene Detail
Symbol

Name
ID
Bbc3
BCL2 binding component 3
MGI:2181667
Synonyms
PUMA
Feature Type
protein coding gene
Genetic Map
Chromosome 7
8.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:16309616-16318205 bp, + strand
From VEGA annotation of GRCm38

  8590 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

HCOP human homology predictions: BBC3
Gene Tree: Bbc3

Human
homologs
BBC3, BCL2 binding component 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27113
neXtProt AC: NX_Q96PG8, NX_Q9BXH1

Human Synonyms: JFY1, JFY-1, PUMA

Human Chr (Location): 19q13.3-q13.4; chr19:47220822-47232996 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from CvDC )
 
Mice homozygous for disruptions in this gene display abnormalities in apoptosis but otherwise are phenotypically normal.
 
Interactions
Bbc3 interacts with 240 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component cytosol, endoplasmic reticulum, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (41)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN bbc3    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000022267 (Evidence)
Ensembl Gene Model ENSMUSG00000002083 (Evidence)
Entrez Gene 170770 (Evidence)
UniGene 7660
DFCI TC1582159
DoTS DT.101709737
NIA Mouse Gene Index U007704
PDB 2VOF, 2ROC
Consensus CDS Project CCDS20847.1
International Mouse Phenotyping Consortium Status Bbc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022267 VEGA Gene Model | MGI Sequence Detail 8590 C57BL/6J ±  kb
transcript OTTMUST00000053027 VEGA | MGI Sequence Detail 1814 Not Applicable 
polypeptide OTTMUSP00000025190 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(20) UniProt(3)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000003124 Bcl-2-binding component 3
References
(Earliest) J:76185 Yu J, et al., PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001 Mar;7(3):673-82
(Latest) J:220466 Jiang L, et al., Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015 Apr 2;520(7545):57-62
All references(120)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory