Xrra1 MGI Mouse Gene Detail - MGI:2181647 - X-ray radiation resistance associated 1

Symbol

Xrra1
Name

X-ray radiation resistance associated 1

Feature Type

protein coding gene
IDs

MGI:2181647
NCBI Gene: 446101
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:99859218-99917824 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.15 cM
Mapping Data

2 experiments

SNPs within 2kb

576 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2181647	protein coding gene	Chr7:99859116-99917824 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032559	protein coding gene	Chr7:102695459-102753996 (+)
A/J	MGP_AJ_G0032533	protein coding gene	Chr7:100136105-100195249 (+)
AKR/J	MGP_AKRJ_G0032469	protein coding gene	Chr7:102520055-102578894 (+)
BALB/cJ	MGP_BALBcJ_G0032544	protein coding gene	Chr7:99804141-99863046 (+)
C3H/HeJ	MGP_C3HHeJ_G0032259	protein coding gene	Chr7:102874897-102936875 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033042	protein coding gene	Chr7:106613182-106676012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030036	protein coding gene	Chr7:102535218-102597235 (+)
CAST/EiJ	MGP_CASTEiJ_G0031586	protein coding gene	Chr7:94402747-94467039 (+)
CBA/J	MGP_CBAJ_G0032226	protein coding gene	Chr7:110292504-110362436 (+)
DBA/2J	MGP_DBA2J_G0032377	protein coding gene	Chr7:98458703-98519388 (+)
FVB/NJ	MGP_FVBNJ_G0032334	protein coding gene	Chr7:98255957-98315578 (+)
LP/J	MGP_LPJ_G0032467	protein coding gene	Chr7:104052585-104120989 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032367	protein coding gene	Chr7:111712273-111771926 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033064	protein coding gene	Chr7:101780208-101841553 (+)
PWK/PhJ	MGP_PWKPhJ_G0031304	protein coding gene	Chr7:91556014-91618582 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031147	protein coding gene	Chr7:89084440-89146454 (+)
WSB/EiJ	MGP_WSBEiJ_G0031703	protein coding gene	Chr7:102461944-102524252 (+)

Human Ortholog

XRRA1, X-ray radiation resistance associated 1

Vertebrate Orthologs

9

Human Ortholog

XRRA1, X-ray radiation resistance associated 1
Orthology source: HomoloGene, HGNC
Links

HGNC:18868

NCBI Gene ID: 143570

neXtProt AC: NX_Q6P2D8

UniProt: Q6P2D8
Chr Location

11q13.4; chr11:74840910-74949187 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 19547
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: XRRA1
Gene Tree

Xrra1

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Xrra1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

2 strains or lines available

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All GO Annotations

5
GO References

1

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xrra1

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Xrra1 interacts with 44 markers (Mir26b, Mir32, Mir92-1, ...) View All

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All Sequences

44
RefSeq

8
UniProt

3
CCDS

CCDS52321.1

Ensembl

ENSMUSG00000035211 (Evidence)
NCBI Gene

446101

			Length	Strain/Species	Flank
genomic	446101	NCBI Gene Model \| MGI Sequence Detail	58607	C57BL/6J	± kb
transcript	NM_001164258	RefSeq \| MGI Sequence Detail	2631	Not Specified
polypeptide	Q3U3V8	UniProt \| EBI \| MGI Sequence Detail	786	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017513 X-ray radiation resistance-associated protein 1

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR038894 X-ray radiation resistance-associated protein 1

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All nucleic 7

cDNA 7

Microarray probesets 1

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MGI:2141964

Summaries

All 28

Gene Ontology 1

Phenotypes 10
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Xrra1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68077	Chr7:99859059-99859120 (+)	-128 bp
Tssr68078	Chr7:99859123-99859140 (+)	-86 bp
Tssr68079	Chr7:99863494-99863504 (+)	4,281 bp
Tssr68080	Chr7:99906326-99906353 (+)	47,122 bp
Tssr68081	Chr7:99906407-99906415 (+)	47,193 bp
Tssr68082	Chr7:99906443-99906450 (+)	47,229 bp
Tssr68083	Chr7:99906516-99906525 (+)	47,303 bp
Tssr68084	Chr7:99906532-99906536 (+)	47,316 bp
Tssr68085	Chr7:99906537-99906552 (+)	47,327 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16