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Slc5a2
Gene Detail
 Symbol
Name
ID
Slc5a2
solute carrier family 5 (sodium/glucose cotransporter), member 2
MGI:2181411
Synonyms Sglt2
Feature Type protein coding gene
Genetic Map
Chromosome 7
70.08 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:128265657-128272430 bp, + strand
From VEGA annotation of GRCm38

  6774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc5a2

Human
homologs
Human Homolog SLC5A2, solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Gene ID 6524
neXtProt AC  NX_P31639
Human Synonyms  SGLT2
Human Chr (Location)  16p11.2; chr16:31483118-31490770 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC5A2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased urine glucose, increased eating and drinking behaviors, increased circulating renin activity, decreased urine osmolality, decreased serum aldosterone levels, polyuria, and decreased glucose renal reabsorption.
 
Interactions
Slc5a2 interacts with 38 markers (Mir16-2, Mir22, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process carbohydrate transport, glucose transport, ...
Component brush border membrane, extracellular vesicular exosome, ...
Function glucose:sodium symporter activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (136)    Images (9)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 140
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(53) cDNA(53)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026291 (Evidence)
Ensembl Gene ModelENSMUSG00000030781 (Evidence)
Entrez Gene246787 (Evidence)
UniGene38870
NIA Mouse Gene IndexU008832
Consensus CDS ProjectCCDS21894.1
International Mouse Knockout Project StatusSlc5a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026291 VEGA Gene Model | MGI Sequence Detail 6774 C57BL/6J ±  kb
transcript OTTMUST00000065033 VEGA | MGI Sequence Detail 2277 Not Applicable 
polypeptide OTTMUSP00000032358 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR018212 Sodium/solute symporter, conserved site
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015169 sodium/glucose cotransporter 2
References (Earliest) J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
(Latest) J:212183 Gembardt F, et al., The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F317-25
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory