Slc5a2
Gene Detail

Symbol Name ID

Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 MGI:2181411

Synonyms

Sglt2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

70.08 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:128265657-128272430 bp, + strand From VEGA annotation of GRCm38   6774 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Slc5a2

Human homologs

Human Homolog		SLC5A2, solute carrier family 5 (sodium/glucose cotransporter), member 2
NCBI Gene ID		6524
neXtProt AC		NX_P31639
Human Synonyms		SGLT2
Human Chr (Location)		16p11.2; chr16:31494439-31502091 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC5A2

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Mice homozygous for a null allele exhibit increased urine glucose, increased eating and drinking behaviors, increased circulating renin activity, decreased urine osmolality, decreased serum aldosterone levels, polyuria, and decreased glucose renal reabsorption.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	carbohydrate transport, glucose transport, ...
Component	brush border membrane, integral to membrane, ...
Function	glucose:sodium symporter activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (100)    Tissues (96)    Images (7)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	100

cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) cDNA(53)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000026291 (Evidence)
Ensembl Gene Model	ENSMUSG00000030781 (Evidence)
Entrez Gene	246787 (Evidence)
UniGene	38870
NIA Mouse Gene Index	U008832
Consensus CDS Project	CCDS21894.1
International Mouse Knockout Project Status	Slc5a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026291	VEGA Gene Model | MGI Sequence Detail	6774	C57BL/6J
transcript	OTTMUST00000065033	VEGA | MGI Sequence Detail	2277	Not Applicable
polypeptide	OTTMUSP00000032358	VEGA | MGI Sequence Detail	670	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001734	Sodium/solute symporter
InterPro	IPR018212	Sodium/solute symporter, conserved site
InterPro	IPR019900	Sodium/solute symporter, subgroup
Protein Ontology	PR:000015169	sodium/glucose cotransporter 2

References

(Earliest) J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
(Latest) J:192346 Vallon V, et al., Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013 Jan;304(2):F156-67
All references(34)