About   Help   FAQ
Capn8 Gene Detail
Summary
  • Symbol
    Capn8
  • Name
    calpain 8
  • Synonyms
    nCL-2, nCL-2'
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181366
    NCBI Gene: 170725
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182392572-182459917 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 85.37 cM, cytoband H4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181366
protein coding gene Chr1:182392314-182462021 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016896
protein coding gene Chr1:189212552-189286506 (+)
A/J MGP_AJ_G0016875
protein coding gene Chr1:181490269-181558799 (+)
AKR/J MGP_AKRJ_G0016840
protein coding gene Chr1:186874335-186944802 (+)
BALB/cJ MGP_BALBcJ_G0016833
protein coding gene Chr1:182123985-182196685 (+)
C3H/HeJ MGP_C3HHeJ_G0016657
protein coding gene Chr1:187688053-187759410 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017296
protein coding gene Chr1:195301203-195376383 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015003
protein coding gene Chr1:172561225-172628265 (+)
CAST/EiJ MGP_CASTEiJ_G0016239
protein coding gene Chr1:187041415-187115317 (+)
CBA/J MGP_CBAJ_G0016631
protein coding gene Chr1:202550735-202624697 (+)
DBA/2J MGP_DBA2J_G0016737
protein coding gene Chr1:180273204-180343365 (+)
FVB/NJ MGP_FVBNJ_G0016733
protein coding gene Chr1:178401584-178469839 (+)
LP/J MGP_LPJ_G0016812
protein coding gene Chr1:190392414-190466558 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016765
protein coding gene Chr1:209551359-209632755 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017333
protein coding gene Chr1:186694983-186776366 (+)
PWK/PhJ MGP_PWKPhJ_G0016027
protein coding gene Chr1:179457771-179532587 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015803
protein coding gene Chr1:185652704-185727138 (+)
WSB/EiJ MGP_WSBEiJ_G0016302
protein coding gene Chr1:186890041-186969731 (+)



Homology
more
  • Human Ortholog
    CAPN8, calpain 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPN8, calpain 8
  • Synonyms
    nCL-2
  • Links
    NCBI Gene ID: 388743
    neXtProt AC: NX_A6NHC0
    UniProt: A6NHC0

  • Chr Location
    1q41; chr1:223538007-223665723 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or allele that produces a proteolytically inactive protein exhibit increased sensitivity to ethanol-induced gastric mucosa injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038599 Ensembl Gene Model | MGI Sequence Detail 67346 C57BL/6J ±  kb
transcript ENSMUST00000048941 Ensembl | MGI Sequence Detail 2406 Not Applicable  
polypeptide ENSMUSP00000047164 Ensembl | MGI Sequence Detail 703 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:75402 Hata S, et al., Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. J Mol Evol. 2001 Sep;53(3):191-203
  • Latest
    J:237762 Hata S, et al., A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively. J Biol Chem. 2016 Dec 30;291(53):27313-27322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory