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Capn8 Gene Detail
Summary
  • Symbol
    Capn8
  • Name
    calpain 8
  • Synonyms
    nCL-2, nCL-2'
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181366
    NCBI Gene: 170725
  • Gene Overview
    MyGene.info: CAPN8
Location & Maps
more
  • Sequence Map
    Chr1:182565007-182632352 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67346 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 85.37 cM, cytoband H4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CAPN8, calpain 8
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CAPN8, calpain 8
    Orthology source: HGNC, HomoloGene
  • Synonyms
    nCL-2
  • Links
    NCBI Gene ID: 388743
    neXtProt AC: NX_A6NHC0

  • Chr Location
    1q41

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or allele that produces a proteolytically inactive protein exhibit increased sensitivity to ethanol-induced gastric mucosa injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050481 VEGA Gene Model | MGI Sequence Detail 67346 C57BL/6J ±  kb
transcript OTTMUST00000128074 VEGA | MGI Sequence Detail 2406 Not Applicable  
polypeptide OTTMUSP00000068963 VEGA | MGI Sequence Detail 703 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    414 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:75402 Hata S, et al., Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution. J Mol Evol. 2001 Sep;53(3):191-203
  • Latest
    J:163312 Hata S, et al., Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genet. 2010;6(7):e1001040

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory