Prokr2
Gene Detail

Symbol Name ID

Prokr2 prokineticin receptor 2 MGI:2181363

Synonyms

B830005M06Rik, EG-VEGRF2, Gpcr73l1, Gpr73l1, PKR2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:132337733-132385447 bp, - strand From VEGA annotation of GRCm38   47715 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:16368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: prokineticin receptor
Gene Tree: Prokr2

Human homologs

Human Homolog		PROKR2, prokineticin receptor 2
NCBI Gene ID		128674
neXtProt AC		NX_Q8NFJ6
Human Synonyms		dJ680N4.3, GPR73b, GPR73L1, GPRg2, HH3, KAL3, PKR2
Human Chr (Location)		20p12.3; chr20:5282686-5295015 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PROKR2

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygotes for a null allele show 50% neonatal lethality, olfactory bulb malformation, and reproductive system atrophy related to a lack of hypothalamic gonadotropin-releasing hormone synthesizing neurons. Homozygotes for another null allele show impaired circadian behavior and thermoregulation.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	circadian rhythm, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, neuropeptide Y receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (94)    Tissues (39)    Images (13)
Theiler Stages: 10, 18, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	19
RT-PCR	75

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(12) Primer pair(4)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000015549 (Evidence)
Ensembl Gene Model	ENSMUSG00000050558 (Evidence)
Entrez Gene	246313 (Evidence)
UniGene	283777
DFCI	TC1585677, TC1684084, TC1748938
DoTS	DT.101709615, DT.87029133, DT.91337614
NIA Mouse Gene Index	U023393
Consensus CDS Project	CCDS16773.1
International Mouse Knockout Project Status	Prokr2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015549	VEGA Gene Model | MGI Sequence Detail	47715	C57BL/6J
transcript	OTTMUST00000036937	VEGA | MGI Sequence Detail	4486	Not Applicable
polypeptide	OTTMUSP00000016571	VEGA | MGI Sequence Detail	381	Not Applicable

All sequences(44) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(147 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000611	Neuropeptide Y receptor
Protein Ontology	PR:000001654	prokineticin receptor 2

References

(Earliest) J:76640 Cheng MY, et al., Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23;417(6887):405-10
(Latest) J:188332 Delogu A, et al., Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron. 2012 Aug 23;75(4):648-62
All references(46)

Other accession IDs

MGI:2441861