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Prokr2
Gene Detail
 Symbol
Name
ID
Prokr2
prokineticin receptor 2
MGI:2181363
Synonyms B830005M06Rik, EG-VEGRF2, Gpcr73l1, Gpr73l1, PKR2
Feature Type protein coding gene
Genetic Map
Chromosome 2
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:132337733-132385447 bp, - strand
From VEGA annotation of GRCm38

  47715 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prokineticin receptor
Gene Tree: Prokr2

Human
homologs
Human Homolog PROKR2, prokineticin receptor 2
NCBI Gene ID 128674
neXtProt AC  NX_Q8NFJ6
Human Synonyms  dJ680N4.3, GPR73b, GPR73L1, GPRg2, HH3, KAL3, PKR2
Human Chr (Location)  20p12.3; chr20:5301065-5316732 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PROKR2
Alleles
and
phenotypes
All alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show 50% neonatal lethality, olfactory bulb malformation, and reproductive system atrophy related to a lack of hypothalamic gonadotropin-releasing hormone synthesizing neurons. Homozygotes for another null allele show impaired circadian behavior and thermoregulation.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process circadian rhythm, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, neuropeptide Y receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (94)    Tissues (39)    Images (13)
Theiler Stages: 10, 18, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 19
RT-PCR 75
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(12) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015549 (Evidence)
Ensembl Gene ModelENSMUSG00000050558 (Evidence)
Entrez Gene246313 (Evidence)
UniGene283777
DFCITC1585677, TC1684084, TC1748938
DoTSDT.101709615, DT.87029133, DT.91337614
NIA Mouse Gene IndexU023393
Consensus CDS ProjectCCDS16773.1
International Mouse Knockout Project StatusProkr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015549 VEGA Gene Model | MGI Sequence Detail 47715 C57BL/6J ±  kb
transcript OTTMUST00000036937 VEGA | MGI Sequence Detail 4486 Not Applicable 
polypeptide OTTMUSP00000016571 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000611 Neuropeptide Y receptor family
Protein Ontology PR:000001654 prokineticin receptor 2
References (Earliest) J:76640 Cheng MY, et al., Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23;417(6887):405-10
(Latest) J:188332 Delogu A, et al., Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron. 2012 Aug 23;75(4):648-62
All references(47)
Other
accession IDs
MGI:2441861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory