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Prokr2
Gene Detail
Symbol

Name
ID
Prokr2
prokineticin receptor 2
MGI:2181363
Synonyms
B830005M06Rik, EG-VEGRF2, Gpcr73l1, Gpr73l1, PKR2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
64.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:132337733-132385447 bp, - strand
From VEGA annotation of GRCm38

  47715 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PROKR2
Protein SuperFamily: prokineticin receptor
Gene Tree: Prokr2

Human
homologs
PROKR2, prokineticin receptor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 128674
neXtProt AC: NX_Q8NFJ6

Human Synonyms: dJ680N4.3, GPR73b, GPR73L1, GPRg2, HH3, KAL3, PKR2

Human Chr (Location): 20p12.3; chr20:5299874-5317547 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PROKR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show 50% neonatal lethality, olfactory bulb malformation, and reproductive system atrophy related to a lack of hypothalamic gonadotropin-releasing hormone synthesizing neurons. Homozygotes for another null allele show impaired circadian behavior and thermoregulation.
 
Phenotype Images(3)
Interactions
Prokr2 interacts with 345 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (94)    Tissues (43)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
RT-PCR 75
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(12) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000015549 (Evidence)
Ensembl Gene Model ENSMUSG00000050558 (Evidence)
Entrez Gene 246313 (Evidence)
UniGene 283777
DFCI TC1585677, TC1684084, TC1748938
DoTS DT.101709615, DT.87029133, DT.91337614
NIA Mouse Gene Index U023393
Consensus CDS Project CCDS16773.1
International Mouse Phenotyping Consortium Status Prokr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015549 VEGA Gene Model | MGI Sequence Detail 47715 C57BL/6J ±  kb
transcript OTTMUST00000036938 VEGA | MGI Sequence Detail 3829 Not Applicable 
polypeptide OTTMUSP00000016572 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000611 Neuropeptide Y receptor family
Protein Ontology PR:000001654 prokineticin receptor 2
References
(Earliest) J:76640 Cheng MY, et al., Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23;417(6887):405-10
(Latest) J:215112 Xiao L, et al., Signaling role of prokineticin 2 on the estrous cycle of female mice. PLoS One. 2014;9(3):e90860
All references(50)
Other
accession IDs
MGI:2441861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory