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Ripply3 Gene Detail
Summary
  • Symbol
    Ripply3
  • Name
    ripply transcriptional repressor 3
  • Synonyms
    Dscr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181192
    NCBI Gene: 170765
Location & Maps
more
  • Sequence Map
    Chr16:94328420-94336935 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8516 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 55.17 cM, cytoband C4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RIPPLY3, ripply transcriptional repressor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RIPPLY3, ripply transcriptional repressor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DSCR6
  • Links
    NCBI Gene ID: 53820
    neXtProt AC: NX_P57055

  • Chr Location
    21q22.13; chr21:37006156-37019659 (+)  GRCh38.p2

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    11
  • Genomic Mutations
    8 involving Ripply3
  • Incidental Mutations
Homozygotes for a reporter allele show complete neonatal lethality, abnormal development of the pharyngeal apparatus and its derivatives including ectopic formation of the thymus and the parathyroid gland, and cardiovascular defects such as deletion of the aortic arch and misshapen great vessels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019884 VEGA Gene Model | MGI Sequence Detail 8516 C57BL/6J ±  kb
transcript OTTMUST00000047411 VEGA | MGI Sequence Detail 1531 Not Applicable  
polypeptide OTTMUSP00000021423 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Diseases 3
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:80502 Reymond A, et al., Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
  • Latest
    J:223933 Okubo T, et al., Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation. Dev Dyn. 2015 Jul;244(7):874-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory