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Klhl10
Gene Detail
 Symbol
Name
ID
Klhl10
kelch-like 10
MGI:2181067
Synonyms 4921517C11Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.47 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:100441917-100457022 bp, + strand
From VEGA annotation of GRCm38

  15106 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12018  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Klhl10

Human
homologs
Human Homolog KLHL10, kelch-like family member 10
NCBI Gene ID 317719
neXtProt AC  NX_Q6JEL2
Human Synonyms  SPGF11
Human Chr (Location)  17q21.2; chr17:41836320-41848347 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KLHL10
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Disruption of one allele results in haploinsufficient male infertility in which heterozygous and chimeric males have a block in spermiogenesis. Female chimeras are fertile.
 
Phenotype Images(1)
Interactions
Klhl10 interacts with 45 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, cell morphogenesis, ...
Component cytoplasm
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006277 (Evidence)
Ensembl Gene ModelENSMUSG00000001558 (Evidence)
Entrez Gene66720 (Evidence)
UniGene34168
DFCITC1584301
DoTSDT.102540822, DT.60117950
NIA Mouse Gene IndexU013339
Consensus CDS ProjectCCDS25423.1
International Mouse Knockout Project StatusKlhl10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006277 VEGA Gene Model | MGI Sequence Detail 15106 C57BL/6J ±  kb
transcript OTTMUST00000014208 VEGA | MGI Sequence Detail 2017 Not Applicable 
polypeptide OTTMUSP00000006597 VEGA | MGI Sequence Detail 608 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR015916 Galactose oxidase, beta-propeller
InterPro IPR017096 Kelch-like protein, gigaxonin
InterPro IPR006652 Kelch repeat type 1
Protein Ontology PR:000009373 kelch-like protein 10
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:175560 Lamberti A, et al., Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011 Oct;93(10):1738-46
All references(30)
Other
accession IDs
MGI:1913970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory