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Klhl10 Gene Detail
Summary
  • Symbol
    Klhl10
  • Name
    kelch-like 10
  • Synonyms
    4921517C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181067
    NCBI Gene: 66720
Location & Maps
more
  • Sequence Map
    Chr11:100441917-100457022 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15106 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLHL10, kelch like family member 10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLHL10, kelch like family member 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPGF11
  • Links
    NCBI Gene ID: 317719
    neXtProt AC: NX_Q6JEL2

  • Chr Location
    17q21.2; chr17:41837490-41848347 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KLHL10 associations

Human Disease Mouse Models
       Spermatogenic Failure 11; SPGF11   OMIM: 615081
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Genomic Mutations
    1 involving Klhl10
  • Incidental Mutations
Disruption of one allele results in haploinsufficient male infertility in which heterozygous and chimeric males have a block in spermiogenesis. Female chimeras are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006277 VEGA Gene Model | MGI Sequence Detail 15106 C57BL/6J ±  kb
transcript OTTMUST00000014208 VEGA | MGI Sequence Detail 2017 Not Applicable  
polypeptide OTTMUSP00000006597 VEGA | MGI Sequence Detail 608 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
less
MGI:1913970
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:175560 Lamberti A, et al., Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011 Oct;93(10):1738-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory