About   Help   FAQ
Oas1a
Gene Detail
Symbol

Name
ID
Oas1a
2'-5' oligoadenylate synthetase 1A
MGI:2180860
Synonyms
L3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
60.65 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr5:120896256-120907521 bp, - strand
From VEGA annotation of GRCm38

  11266 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1903  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 1 dog

Protein SuperFamily: oligo(A) synthetase
Gene Tree: Oas1a

Human
homologs
Human Homolog OAS1, 2'-5'-oligoadenylate synthetase 1, 40/46kDa
NCBI Gene ID 4938
neXtProt AC  NX_P00973
Human Synonyms  IFI-4, OIAS, OIASI
Human Chr (Location)  12q24.2; chr12:112906934-112919907 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OAS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Oas1a interacts with 156 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process negative regulation of viral process
Component cytoplasm, nucleus
Function 2'-5'-oligoadenylate synthetase activity, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (62)    Tissues (10)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) Genomic(1) cDNA(45)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000026831 (Evidence)
Ensembl Gene ModelENSMUSG00000052776 (Evidence)
Entrez Gene246730 (Evidence)
UniGene14301
Consensus CDS ProjectCCDS19630.1
International Mouse Knockout Project StatusOas1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026831 VEGA Gene Model | MGI Sequence Detail 11266 C57BL/6J ±  kb
transcript OTTMUST00000066360 VEGA | MGI Sequence Detail 1885 Not Applicable 
polypeptide OTTMUSP00000033247 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4)
Polymorphisms
SNPs within 2kb(10 from dbSNP Build 137)    SNPs within 2kb including multiple locations(14)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000012101 2'-5'-oligoadenylate synthetase 1A
References
(Earliest) J:34026 Ichii Y, et al., Mouse 2-5A synthetase cDNA: nucleotide sequence and comparison to human 2-5A synthetase. Nucleic Acids Res. 1986 Dec 22;14(24):10117
(Latest) J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory