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Oas1a Gene Detail
Summary
  • Symbol
    Oas1a
  • Name
    2'-5' oligoadenylate synthetase 1A
  • Synonyms
    L3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180860
    NCBI Gene: 246730
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121034319-121045584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.65 cM, cytoband F
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180860
 protein coding gene Chr5:121034319-121045588 (-)
129S1/SvImJ ENSMUSG00200024139
 protein coding gene Chr5:114773592-114784832 (-)
A/J ENSMUSG00195010744
 protein coding gene Chr5:114294793-114306033 (-)
AKR/J ENSMUSG00220045159
 protein coding gene Chr5:113795689-113806958 (-)
BALB/cJ ENSMUSG00180032582
 protein coding gene Chr5:114409381-114420621 (-)
C3H/HeJ ENSMUSG00175020785
 protein coding gene Chr5:116407416-116418656 (-)
C57BL/6NJ ENSMUSG00215043251
 protein coding gene Chr5:114441251-114452519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027673
 protein coding gene Chr5:113839997-113846041 (-)
CAST/EiJ ENSTCUG00005038095
 protein coding gene Chr5:113647500-113664313 (-)
CBA/J ENSMUSG00210007342
 protein coding gene Chr5:115158293-115169533 (-)
DBA/2J ENSMUSG00185052896
 protein coding gene Chr5:118217592-118228859 (-)
FVB/NJ ENSMUSG00205043483
 protein coding gene Chr5:114071421-114082662 (-)
JF1/MsJ ENSUMUG00000050124
 protein coding gene Chr5:121060469-121071723 (-)
LP/J ENSMUSG00230039646
 protein coding gene Chr5:122295786-122307026 (-)
NOD/ShiLtJ ENSMUSG00190025022
 protein coding gene Chr5:114105496-114116736 (-)
NZO/HlLtJ ENSMUSG00225014255
 protein coding gene Chr5:129972886-129984153 (-)
PWK/PhJ ENSLUMG00010029824
 protein coding gene Chr5:112963051-112974298 (-)
SPRET/EiJ ENSMSPG00010034460
 protein coding gene Chr5:116287250-116298521 (-)
WSB/EiJ ENSIUOG00005016833
 protein coding gene Chr5:116789717-116800984 (-)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    660
  • Tissues
    11
  • cDNA Data
    46
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052776 Ensembl Gene Model | MGI Sequence Detail 11266 C57BL/6J ±  kb
transcript ENSMUST00000080322 Ensembl | MGI Sequence Detail 1885 Not Applicable  
polypeptide ENSMUSP00000079198 Ensembl | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    Genomic 1
    cDNA 46

    Microarray probesets 1
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 14
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory