About   Help   FAQ
Oas3 Gene Detail
Summary
  • Symbol
    Oas3
  • Name
    2'-5' oligoadenylate synthetase 3
  • Synonyms
    2'-5' oligoadenylate synthetase-like 10, Oasl10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180850
    NCBI Gene: 246727
  • Gene Overview
    MyGene.info: OAS3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120753098-120777659 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband f
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180850
protein coding gene Chr5:120753098-120777661 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030014
protein coding gene Chr5:124159977-124185661 (-)
A/J MGP_AJ_G0029978
protein coding gene Chr5:119001855-119026413 (-)
AKR/J MGP_AKRJ_G0029917
protein coding gene Chr5:122844430-122870245 (-)
BALB/cJ MGP_BALBcJ_G0029989
protein coding gene Chr5:120418537-120443116 (-)
C3H/HeJ MGP_C3HHeJ_G0029709
protein coding gene Chr5:123383676-123410332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030444
protein coding gene Chr5:128809970-128841359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027670
protein coding gene Chr5:113706675-113732205 (-)
CAST/EiJ MGP_CASTEiJ_G0029118
protein coding gene Chr5:122512696-122538487 (-)
CBA/J MGP_CBAJ_G0029677
protein coding gene Chr5:133818029-133849459 (-)
DBA/2J MGP_DBA2J_G0029827
protein coding gene Chr5:119090150-119114617 (-)
FVB/NJ MGP_FVBNJ_G0029783
protein coding gene Chr5:118021171-118047558 (-)
LP/J MGP_LPJ_G0029915
protein coding gene Chr5:124607506-124635975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029814
protein coding gene Chr5:137761736-137786628 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030485
protein coding gene Chr5:122420905-122447615 (-)
PWK/PhJ MGP_PWKPhJ_G0028831
protein coding gene Chr5:117850846-117877945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028670
protein coding gene Chr5:120087968-120125739 (-)
WSB/EiJ MGP_WSBEiJ_G0029193
protein coding gene Chr5:123015626-123040922 (-)



Homology
more
  • Human Ortholog
    OAS3, 2'-5'-oligoadenylate synthetase 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    OAS3, 2'-5'-oligoadenylate synthetase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p100, p100OAS
  • Links
    NCBI Gene ID: 4940
    neXtProt AC: NX_Q9Y6K5
    UniProt: Q9Y6K5

  • Chr Location
    12q24.13; chr12:112938433-112973251 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246727 NCBI Gene Model | MGI Sequence Detail 24562 C57BL/6J ±  kb
transcript NM_145226 RefSeq | MGI Sequence Detail 4718 C57BL/6  
polypeptide Q8VI93 UniProt | EBI | MGI Sequence Detail 1138 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011576 2'-5'-oligoadenylate synthase 3
  • EC
  • InterPro Domains
    IPR026774 2'-5'-oligoadenylate synthase
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, conserved site
    IPR038121 2'-5'-oligoadenylate synthetase, domain 2 superfamily
    IPR006116 2-5-oligoadenylate synthetase, N-terminal
    IPR002934 Polymerase, nucleotidyl transferase domain
Molecular
Reagents
less
  • All nucleic 24
    Genomic 9
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory