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Oasl1 Gene Detail
Summary
  • Symbol
    Oasl1
  • Name
    2'-5' oligoadenylate synthetase-like 1
  • Synonyms
    7530414C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180849
    NCBI Gene: 231655
  • Gene Overview
    MyGene.info: OASL
Location & Maps
more
  • Sequence Map
    Chr5:114923240-114937915 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14676 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    OASL, 2'-5'-oligoadenylate synthetase like
  • Vertebrate Orthologs
    5
  • Human Ortholog
    OASL, 2'-5'-oligoadenylate synthetase like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OASLd, p59OASL, p59 OASL, p59-OASL, TRIP14, TRIP-14
  • Links
    NCBI Gene ID: 8638
    neXtProt AC: NX_Q15646

  • Chr Location
    12q24.2; chr12:121020292-121039242 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Oasl1
  • Incidental Mutations
    APF
Mice with a deletion of this gene have increased expression of type I interferon and show increased resistance to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014607 VEGA Gene Model | MGI Sequence Detail 14676 C57BL/6J ±  kb
transcript OTTMUST00000034645 VEGA | MGI Sequence Detail 2125 Not Applicable  
polypeptide OTTMUSP00000015517 VEGA | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011577 2'-5'-oligoadenylate synthase-like protein 1
  • InterPro Domains
    IPR026774 2'-5'-oligoadenylate synthase
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR006117 2-5-oligoadenylate synthetase, conserved site
    IPR006116 2-5-oligoadenylate synthetase, N-terminal
    IPR000626 Ubiquitin domain
    IPR029071 Ubiquitin-related domain
Molecular
Reagents
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  • All nucleic 25
    cDNA 25

    Microarray probesets 4
Other
Accession IDs
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MGI:2443464
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:77001 Perelygin AA, et al., Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9322-7
  • Latest
    J:213471 Lee MS, et al., Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8(+) T-cell exhaustion. PLoS Pathog. 2013;9(7):e1003478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory