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Oasl1
Gene Detail
Symbol

Name
ID
Oasl1
2'-5' oligoadenylate synthetase-like 1
MGI:2180849
Synonyms
7530414C13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:114923240-114937915 bp, + strand
From VEGA annotation of GRCm38

  14676 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Oasl1

Human
homologs
Human Homolog OASL, 2'-5'-oligoadenylate synthetase-like
NCBI Gene ID 8638
neXtProt AC  NX_Q15646
Human Synonyms  OASLd, p59OASL, p59 OASL, p59-OASL, TRIP14, TRIP-14
Human Chr (Location)  12q24.2; chr12:121020292-121039242 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 
Mice with a deletion of this gene have increased expression of type I interferon and show increased resistance to viral infection.
 
Interactions
Oasl1 interacts with 75 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process defense response to virus, immune response, ...
Component cytoplasm, membrane, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(25)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014607 (Evidence)
Ensembl Gene ModelENSMUSG00000041827 (Evidence)
Entrez Gene231655 (Evidence)
UniGene95479
DFCITC1572588
DoTSDT.101360049, DT.94028763, DT.99857563
NIA Mouse Gene IndexU006039
Consensus CDS ProjectCCDS19575.1
International Mouse Knockout Project StatusOasl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014607 VEGA Gene Model | MGI Sequence Detail 14676 C57BL/6J ±  kb
transcript OTTMUST00000034645 VEGA | MGI Sequence Detail 2125 Not Applicable 
polypeptide OTTMUSP00000015517 VEGA | MGI Sequence Detail 511 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026774 2'-5'-oligoadenylate synthase
InterPro IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
InterPro IPR006117 2-5-oligoadenylate synthetase, conserved site
InterPro IPR006116 2-5-oligoadenylate synthetase, N-terminal
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000034502 2'-5'-oligoadenylate synthase-like protein 1
References
(Earliest) J:77001 Perelygin AA, et al., Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9322-7
(Latest) J:213471 Lee MS, et al., Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8(+) T-cell exhaustion. PLoS Pathog. 2013;9(7):e1003478
All references(33)
Other
accession IDs
MGI:2443464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory