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Il31ra Gene Detail
Summary
  • Symbol
    Il31ra
  • Name
    interleukin 31 receptor A
  • Synonyms
    GLM-R, GPL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180511
    NCBI Gene: 218624
  • Gene Overview
    MyGene.info: IL31RA
Location & Maps
more
  • Sequence Map
    Chr13:112522810-112580662 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57853 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.75 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL31RA, interleukin 31 receptor A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL31RA, interleukin 31 receptor A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRL, CRL3, GLMR, GLM-R, GPL, hGLM-R, IL-31RA, PLCA2, PRO21384
  • Links
    NCBI Gene ID: 133396
    neXtProt AC: NX_Q8NI17

  • Chr Location
    5q11.2; chr5:55840334-55922854 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL31RA associations

Human Disease Mouse Models
       Amyloidosis, Primary Localized Cutaneous, 2; PLCA2   OMIM: 613955
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    6
  • Transgenic
    2
  • Incidental Mutations
Homozygous null mice display no apparent abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050377 Ensembl Gene Model | MGI Sequence Detail 57853 C57BL/6J ±  kb
transcript ENSMUST00000051756 Ensembl | MGI Sequence Detail 3665 Not Applicable  
polypeptide ENSMUSP00000058045 Ensembl | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    591 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 33
    cDNA 33

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:76557 Ghilardi N, et al., A Novel Type I Cytokine Receptor Is Expressed on Monocytes, Signals Proliferation, and Activates STAT-3 and STAT-5. J Biol Chem. 2002 May 10;277(19):16831-6
  • Latest
    J:172699 Shen M, et al., Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31. Exp Cell Res. 2011 Apr 15;317(7):976-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory