Il31ra MGI Mouse Gene Detail - MGI:2180511

Symbol

Il31ra
Name

interleukin 31 receptor A
Synonyms

GLM-R, GPL

Feature Type

protein coding gene
IDs

MGI:2180511
NCBI Gene: 218624
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:112649439-112717266 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.75 cM
Mapping Data

1 experiment

SNPs within 2kb

483 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2180511	protein coding gene	Chr13:112649439-112730894 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020937	protein coding gene	Chr13:115085659-115143322 (-)
A/J	MGP_AJ_G0020887	protein coding gene	Chr13:110490040-110549684 (-)
AKR/J	MGP_AKRJ_G0020862	protein coding gene	Chr13:113827796-113887712 (-)
BALB/cJ	MGP_BALBcJ_G0020887	protein coding gene	Chr13:111189623-111248015 (-)
C3H/HeJ	MGP_C3HHeJ_G0020676	protein coding gene	Chr13:113620941-113683613 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021323	protein coding gene	Chr13:118508091-118567967 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018892	protein coding gene	Chr13:105792122-105835326 (-)
CAST/EiJ	MGP_CASTEiJ_G0020196	protein coding gene	Chr13:113239814-113299366 (-)
CBA/J	MGP_CBAJ_G0020638	protein coding gene	Chr13:123086618-123151882 (-)
DBA/2J	MGP_DBA2J_G0020761	protein coding gene	Chr13:110207443-110264882 (-)
FVB/NJ	MGP_FVBNJ_G0020745	protein coding gene	Chr13:108899540-108957390 (-)
LP/J	MGP_LPJ_G0020837	protein coding gene	Chr13:115130577-115191069 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020773	protein coding gene	Chr13:123365652-123425819 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021359	protein coding gene	Chr13:113271185-113340686 (-)
PWK/PhJ	MGP_PWKPhJ_G0019949	protein coding gene	Chr13:108943117-109002116 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019771	protein coding gene	Chr13:109607344-109669128 (-)
WSB/EiJ	MGP_WSBEiJ_G0020253	protein coding gene	Chr13:113885583-113947155 (-)

Human Ortholog

IL31RA, interleukin 31 receptor A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL31RA, interleukin 31 receptor A
Synonyms

CRL, CRL3, GLMR, GLM-R, GPL, hGLM-R, IL-31RA, PLCA2, PRO21384, zcytoR17
Links

HGNC:18969

NCBI Gene ID: 133396

neXtProt AC: NX_Q8NI17

UniProt: Q8NI17
Chr Location

5q11.2; chr5:55839789-55922854 (+) GRCh38

MGI Vertebrate Homology

Il31ra stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL31RA
Gene Tree

Il31ra

Diseases

1 with human IL31RA associations

				Human Disease	Mouse Models
				primary localized cutaneous amyloidosis 2 IDs primary localized cutaneous amyloidosis 2 DOID:0080931 OMIM:613955

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

30 phenotypes from 5 alleles in 5 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Targeted

7
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display no apparent abnormalities.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

10
cDNA Data

34
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

69
RefSeq

17
UniProt

7
CCDS

CCDS36781.1

Ensembl

ENSMUSG00000050377 (Evidence)
NCBI Gene

218624

			Length	Strain/Species	Flank
genomic	218624	NCBI Gene Model \| MGI Sequence Detail	67828	C57BL/6J	± kb
transcript	NM_139299	RefSeq \| MGI Sequence Detail	3680	C57BL/6
polypeptide	Q8K5B1	UniProt \| EBI \| MGI Sequence Detail	716	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000009004 interleukin-31 receptor A

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

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All nucleic 34

cDNA 34

Microarray probesets 2

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 21
Earliest

J:76557 Ghilardi N, et al., A Novel Type I Cytokine Receptor Is Expressed on Monocytes, Signals Proliferation, and Activates STAT-3 and STAT-5. J Biol Chem. 2002 May 10;277(19):16831-6
Latest

J:344731 Fassett MS, et al., IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis. Sci Immunol. 2023 Oct 20;8(88):eabi6887

TSS for Il31ra:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124062	Chr13:112717245-112717262 (-)	12 bp
Tssr124061	Chr13:112714842-112714889 (-)	2,400 bp
Tssr124060	Chr13:112698563-112698571 (-)	18,699 bp
Tssr124059	Chr13:112688652-112688666 (-)	28,607 bp
Tssr124058	Chr13:112688636-112688651 (-)	28,622 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23