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Prok1 Gene Detail
Summary
  • Symbol
    Prok1
  • Name
    prokineticin 1
  • Synonyms
    EG-VEGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180370
    NCBI Gene: 246691
Location & Maps
more
  • Sequence Map
    Chr3:107232797-107239707 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6911 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.72 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PROK1, prokineticin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PROK1, prokineticin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EGVEGF, PK1, PRK1
  • Links
    NCBI Gene ID: 84432
    neXtProt AC: NX_P58294

  • Chr Location
    1p21; chr1:110451166-110457354 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13023
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PROK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Prok1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052945 VEGA Gene Model | MGI Sequence Detail 6911 C57BL/6J ±  kb
transcript OTTMUST00000132492 VEGA | MGI Sequence Detail 813 Not Applicable  
polypeptide OTTMUSP00000070639 VEGA | MGI Sequence Detail 105 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    145 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 7
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:76640 Cheng MY, et al., Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23;417(6887):405-10
  • Latest
    J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory