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Zar1
Gene Detail
Symbol

Name
ID
Zar1
zygote arrest 1
MGI:2180337
Feature Type
protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:72577114-72581084 bp, - strand
From VEGA annotation of GRCm38

  3971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18370  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZAR1
Gene Tree: Zar1

Human
homologs
ZAR1, zygote arrest 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 326340
neXtProt AC: NX_Q86SH2

Human Synonyms: Z3CXXC6

Human Chr (Location): 4p11; chr4:48490252-48498122 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Zar1 (1)
Incidental mutations (data from APF , CvDC )
 
Ovarian development and oogenesis are normal in homozygous null females, however they are infertile due to a failure at the oocyte to embryo transition.
 
Phenotype Images(4)
Interactions
Zar1 interacts with 24 markers (Mir27a, Mir27b, Mir181d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process multicellular organismal development
Component cytoplasm
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (63)    Tissues (24)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 18
Northern blot 4
Western blot 4
RT-PCR 18
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase zar1 ; ZFIN zar1    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026978 (Evidence)
Ensembl Gene Model ENSMUSG00000063935 (Evidence)
Entrez Gene 317755 (Evidence)
UniGene 11934
DFCI TC1580849
DoTS DT.40175838
NIA Mouse Gene Index U026289
Consensus CDS Project CCDS19331.1
International Mouse Phenotyping Consortium Status Zar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026978 VEGA Gene Model | MGI Sequence Detail 3971 C57BL/6J ±  kb
transcript OTTMUST00000066679 VEGA | MGI Sequence Detail 1259 Not Applicable 
polypeptide OTTMUSP00000033455 VEGA | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)    SNPs within 2kb including multiple locations(150)
Protein-related
information
ResourceIDDescription
InterPro IPR027377 Zinc-binding domain
InterPro IPR026775 Zygote arrest protein 1
Protein Ontology PR:000017558 zygote arrest protein 1
References
(Earliest) J:81447 Wu X, et al., Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nat Genet. 2003 Feb;33(2):187-91
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory