About   Help   FAQ
Zar1 Gene Detail
Summary
  • Symbol
    Zar1
  • Name
    zygote arrest 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180337
    NCBI Gene: 317755
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:72577113-72581362 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180337
protein coding gene Chr5:72576806-72581362 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029613
protein coding gene Chr5:72500906-72518341 (-)
A/J MGP_AJ_G0029581
protein coding gene Chr5:69815493-69819810 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0029598
protein coding gene Chr5:70968687-70976065 (+)
C3H/HeJ MGP_C3HHeJ_G0029313
protein coding gene Chr5:72385834-72401712 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0027284
protein coding gene Chr5:65519199-65523363 (-)
CAST/EiJ MGP_CASTEiJ_G0028721
protein coding gene Chr5:71516036-71520505 (-)
CBA/J MGP_CBAJ_G0029282
protein coding gene Chr5:77915156-77928359 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0029423
protein coding gene Chr5:81772276-81783475 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030085
protein coding gene Chr5:72080695-72089872 (+)
PWK/PhJ MGP_PWKPhJ_G0028452
protein coding gene Chr5:69278667-69285006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028287
protein coding gene Chr5:71432942-71438432 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZAR1, zygote arrest 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZAR1, zygote arrest 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Z3CXXC6
  • Links
    NCBI Gene ID: 326340
    neXtProt AC: NX_Q86SH2
    UniProt: Q86SH2

  • Chr Location
    4p11; chr4:48490252-48497528 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18370
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZAR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Ovarian development and oogenesis are normal in homozygous null females, however they are infertile due to a failure at the oocyte to embryo transition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 317755 NCBI Gene Model | MGI Sequence Detail 4250 C57BL/6J ±  kb
    transcript NM_174877 RefSeq | MGI Sequence Detail 1284 C57BL/6  
    polypeptide Q80SU3 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 20
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory