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Neto1
Gene Detail
 Symbol
Name
ID
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
MGI:2180216
Synonyms C130005O10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 18
58.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:86394952-86501897 bp, + strand
From NCBI annotation of GRCm38

  106946 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16367  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Neto1

Human
homologs
Human Homolog NETO1, neuropilin (NRP) and tolloid (TLL)-like 1
NCBI Gene ID 81832
neXtProt AC  NX_Q8TDF5
Human Synonyms  BCTL1, BTCL1
Human Chr (Location)  18q22.2; chr18:72742314-72867591 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process memory, positive regulation of excitatory postsynaptic membrane potential, ...
Component cell junction, excitatory synapse, ...
Function ionotropic glutamate receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000050321 (Evidence)
Entrez Gene246317 (Evidence)
DFCITC1585652, TC1597758, TC1697011
DoTSDT.87047705, DT.110774034
NIA Mouse Gene IndexU018976
Consensus CDS ProjectCCDS29387.1
International Mouse Knockout Project StatusNeto1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 246317 NCBI Gene Model | MGI Sequence Detail 106946 C57BL/6J ±  kb
transcript NM_144946 RefSeq | MGI Sequence Detail 3531 C57BL/6 
polypeptide Q8R4I7 UniProt | EBI | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(18) UniProt(1)
Polymorphisms SNPs within 2kb(834 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Protein Ontology PR:000011143 neuropilin and tolloid-like protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:76401 Stohr H, et al., A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. Gene. 2002 Mar 20;286(2):223-31
(Latest) J:205577 Wyeth MS, et al., Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses. J Neurosci. 2014 Jan 8;34(2):622-8
All references(33)
Other
accession IDs
MGI:2147275, MGI:2443543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory