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Neto1 Gene Detail
Summary
  • Symbol
    Neto1
  • Name
    neuropilin (NRP) and tolloid (TLL)-like 1
  • Synonyms
    C130005O10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180216
    NCBI Gene: 246317
  • Gene Overview
    MyGene.info: NETO1
Location & Maps
more
  • Sequence Map
    Chr18:86394952-86501897 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106946 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 58.47 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NETO1, neuropilin and tolloid like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NETO1, neuropilin and tolloid like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCTL1, BTCL1
  • Links
    NCBI Gene ID: 81832
    neXtProt AC: NX_Q8TDF5

  • Chr Location
    18q22.2; chr18:72742314-72867575 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050321 Ensembl Gene Model | MGI Sequence Detail 106946 C57BL/6J ±  kb
transcript ENSMUST00000058829 Ensembl | MGI Sequence Detail 3531 Not Applicable  
polypeptide ENSMUSP00000057340 Ensembl | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    851 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011143 neuropilin and tolloid-like protein 1
  • InterPro Domains
    IPR000859 CUB domain
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR028867 Neuropilin and tolloid-like protein 1
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 5
Other
Accession IDs
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MGI:2147275, MGI:2443543
References
more
  • Summaries
    All 32
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:76401 Stohr H, et al., A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. Gene. 2002 Mar 20;286(2):223-31
  • Latest
    J:225578 Krishnaswamy A, et al., Sidekick 2 directs formation of a retinal circuit that detects differential motion. Nature. 2015 Aug 27;524(7566):466-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory