About   Help   FAQ
Edem1 Gene Detail
Summary
  • Symbol
    Edem1
  • Name
    ER degradation enhancer, mannosidase alpha-like 1
  • Synonyms
    A130059K23Rik, mKIAA0212
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180139
    NCBI Gene: 192193
  • Gene Overview
    MyGene.info: EDEM1
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:108828641-108859356 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 49.87 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180139
 protein coding gene Chr6:108828558-108859356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031103
 protein coding gene Chr6:111117088-111163352 (+)
A/J MGP_AJ_G0031072
 protein coding gene Chr6:106912001-106942987 (+)
AKR/J MGP_AKRJ_G0031003
 protein coding gene Chr6:109791307-109825601 (+)
BALB/cJ MGP_BALBcJ_G0031083
 protein coding gene Chr6:106836409-106867957 (+)
C3H/HeJ MGP_C3HHeJ_G0030625
 protein coding gene Chr6:74533541-74567059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031542
 protein coding gene Chr6:114036682-114068830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028706
 protein coding gene Chr6:104195099-104225409 (+)
CAST/EiJ MGP_CASTEiJ_G0030190
 protein coding gene Chr6:110176358-110208447 (+)
CBA/J MGP_CBAJ_G0030769
 protein coding gene Chr6:118435487-118475864 (+)
DBA/2J MGP_DBA2J_G0030922
 protein coding gene Chr6:106045175-106078194 (+)
FVB/NJ MGP_FVBNJ_G0030876
 protein coding gene Chr6:105077027-105112872 (+)
LP/J MGP_LPJ_G0031002
 protein coding gene Chr6:111174633-111210028 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030910
 protein coding gene Chr6:122637489-122678141 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031569
 protein coding gene Chr6:109738426-109770100 (+)
PWK/PhJ MGP_PWKPhJ_G0029906
 protein coding gene Chr6:104981687-105013491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029734
 protein coding gene Chr6:108522037-108553741 (+)
WSB/EiJ MGP_WSBEiJ_G0030274
 protein coding gene Chr6:110267669-110302397 (+)



Homology
more
  • Human Ortholog
    EDEM1, ER degradation enhancing alpha-mannosidase like protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EDEM1, ER degradation enhancing alpha-mannosidase like protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDEM
  • Links
    NCBI Gene ID: 9695
    neXtProt AC: NX_Q92611
    UniProt: Q92611

  • Chr Location
    3p26.1; chr3:5187674-5219965 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    2
  • cDNA Data
    183
  • Literature Summary
    12
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030104 Ensembl Gene Model | MGI Sequence Detail 30716 C57BL/6J ±  kb
transcript ENSMUST00000089162 Ensembl | MGI Sequence Detail 5817 Not Applicable  
polypeptide ENSMUSP00000086565 Ensembl | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 185
    cDNA 183
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2442942
References
more
  • Summaries
    All 51
    Developmental Gene Expression 12
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:76183 Hosokawa N, et al., A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep. 2001 May;2(5):415-22
  • Latest
    J:265679 Wang B, et al., The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest. 2018 Aug 1;128(8):3319-3332
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
03/13/2019
MGI 6.13 		The Jackson Laboratory