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Edem1 Gene Detail
Summary
  • Symbol
    Edem1
  • Name
    ER degradation enhancer, mannosidase alpha-like 1
  • Synonyms
    A130059K23Rik, mKIAA0212
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180139
    NCBI Gene: 192193
  • Gene Overview
    MyGene.info: EDEM1
Location & Maps
more
  • Sequence Map
    Chr6:108828641-108859356 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      30716 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 49.87 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EDEM1, ER degradation enhancing alpha-mannosidase like protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EDEM1, ER degradation enhancing alpha-mannosidase like protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDEM
  • Links
    NCBI Gene ID: 9695
    neXtProt AC: NX_Q92611

  • Chr Location
    3p26.1; chr3:5187674-5219965 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Edem1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    2
  • Tissues
    1
  • cDNA Data
    182
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056450 VEGA Gene Model | MGI Sequence Detail 30716 C57BL/6J ±  kb
transcript OTTMUST00000139451 VEGA | MGI Sequence Detail 5817 Not Applicable  
polypeptide OTTMUSP00000073166 VEGA | MGI Sequence Detail 652 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    326 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000006892 ER degradation-enhancing alpha-mannosidase-like protein 1
  • EC
    3.2.1.-
  • InterPro Domains
    IPR001382 Glycoside hydrolase family 47
Molecular
Reagents
less
  • All nucleic 183
    cDNA 182
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2442942
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 4
  • Earliest
    J:76183 Hosokawa N, et al., A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation. EMBO Rep. 2001 May;2(5):415-22
  • Latest
    J:208389 Slominska-Wojewodzka M, et al., The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol. Biochem J. 2014 Feb 1;457(3):485-96
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory