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Cd207
Gene Detail
Symbol

Name
ID
Cd207
CD207 antigen
MGI:2180021
Synonyms
Langerin
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:83671207-83677857 bp, - strand
From NCBI annotation of GRCm38

  6651 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 31 western clawed frog

HCOP human homology predictions: CD207
Gene Tree: Cd207

Human
homologs
CD207, CD207 molecule, langerin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 50489
neXtProt AC: NX_Q9UJ71

Human Synonyms: CLEC4K

Human Chr (Location): 2p13; chr2:70825208-70836601 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD207

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Spontaneous(1) Targeted(8)
Genomic Mutations involving Cd207 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection.
 
Interactions
Cd207 interacts with 93 markers (Mir16-2, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process defense response to virus
Component integral component of membrane, integral component of plasma membrane, ...
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000034783 (Evidence)
Entrez Gene 246278 (Evidence)
UniGene 136079
DFCI TC1589657
DoTS DT.482291
NIA Mouse Gene Index U027535
Consensus CDS Project CCDS39534.1
International Mouse Phenotyping Consortium Status Cd207
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 246278 NCBI Gene Model | MGI Sequence Detail 6651 C57BL/6J ±  kb
transcript NM_144943 RefSeq | MGI Sequence Detail 1530 C57BL/6 
polypeptide Q8VBX4 UniProt | EBI | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001293 C-type lectin domain family 4 member K
Graphical View of Protein Domain Structure
References
(Earliest) J:59970 Valladeau J, et al., Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81
(Latest) J:218051 Zaric M, et al., Dissolving microneedle delivery of nanoparticle-encapsulated antigen elicits efficient cross-priming and Th1 immune responses by murine langerhans cells. J Invest Dermatol. 2015 Feb;135(2):425-34
All references(90)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory