Cd207
Gene Detail

Symbol Name ID

Cd207 CD207 antigen MGI:2180021

Synonyms

Langerin

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.94 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:83671207-83677857 bp, - strand From NCBI annotation of GRCm38   6651 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Cd207

Human homologs

Human Homolog		CD207, CD207 molecule, langerin
NCBI Gene ID		50489
neXtProt AC		NX_Q9UJ71
Human Synonyms		CLEC4K
Human Chr (Location)		2p13; chr2:71057343-71062953 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD207

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	defense response to virus
Component	integral to membrane, integral to plasma membrane, ...
Function	carbohydrate binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) Genomic(1) cDNA(3) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000034783 (Evidence)
Entrez Gene	246278 (Evidence)
UniGene	136079
DFCI	TC1589657
DoTS	DT.482291
NIA Mouse Gene Index	U027535
Consensus CDS Project	CCDS39534.1
International Mouse Knockout Project Status	Cd207

Sequences

Length	Strain/Species
genomic	246278	NCBI Gene Model | MGI Sequence Detail	6651	C57BL/6J
transcript	NM_144943	RefSeq | MGI Sequence Detail	1530	C57BL/6
polypeptide	Q8VBX4	UniProt | EBI | MGI Sequence Detail	331	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001304	C-type lectin
InterPro	IPR018378	C-type lectin, conserved site
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
Protein Ontology	PR:000001293	C-type lectin domain family 4 member K

Graphical View of Protein Domain Structure

References

(Earliest) J:59970 Valladeau J, et al., Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81
(Latest) J:194499 Idoyaga J, et al., Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest. 2013 Jan 9;
All references(70)