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Cd207
Gene Detail
 Symbol
Name
ID
Cd207
CD207 antigen
MGI:2180021
Synonyms Langerin
Feature Type protein coding gene
Genetic Map
Chromosome 6
35.94 cM, cytoband D1-D2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:83671207-83677857 bp, - strand
From NCBI annotation of GRCm38

  6651 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9252  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Cd207

Human
homologs
Human Homolog CD207, CD207 molecule, langerin
NCBI Gene ID 50489
neXtProt AC  NX_Q9UJ71
Human Synonyms  CLEC4K
Human Chr (Location)  2p13; chr2:70830212-70835823 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD207
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection.
 
Interactions
Cd207 interacts with 93 markers (Mir16-2, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process defense response to virus
Component integral component of membrane, integral component of plasma membrane, ...
Function carbohydrate binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(3) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000034783 (Evidence)
Entrez Gene246278 (Evidence)
UniGene136079
DFCITC1589657
DoTSDT.482291
NIA Mouse Gene IndexU027535
Consensus CDS ProjectCCDS39534.1
International Mouse Knockout Project StatusCd207
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 246278 NCBI Gene Model | MGI Sequence Detail 6651 C57BL/6J ±  kb
transcript NM_144943 RefSeq | MGI Sequence Detail 1530 C57BL/6 
polypeptide Q8VBX4 UniProt | EBI | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR018378 C-type lectin, conserved site
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001293 C-type lectin domain family 4 member K
Graphical View of Protein Domain Structure
References (Earliest) J:59970 Valladeau J, et al., Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81
(Latest) J:210830 Yoshiki R, et al., IL-23 from Langerhans Cells Is Required for the Development of Imiquimod-Induced Psoriasis-Like Dermatitis by Induction of IL-17A-Producing gammadelta T Cells. J Invest Dermatol. 2014 Jul;134(7):1912-21
All references(82)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory