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Cd207 Gene Detail
Summary
  • Symbol
    Cd207
  • Name
    CD207 antigen
  • Synonyms
    Langerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180021
    NCBI Gene: 246278
  • Gene Overview
    MyGene.info: CD207
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83671215-83677857 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband D1-D2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180021
protein coding gene Chr6:83671207-83677857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030936
protein coding gene Chr6:84693826-84700491 (-)
A/J MGP_AJ_G0030905
protein coding gene Chr6:81476730-81483399 (-)
AKR/J MGP_AKRJ_G0030833
protein coding gene Chr6:83830631-83837273 (-)
BALB/cJ MGP_BALBcJ_G0030915
protein coding gene Chr6:81496431-81503096 (-)
C3H/HeJ MGP_C3HHeJ_G0030795
protein coding gene Chr6:100563256-100569898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031375
protein coding gene Chr6:87033655-87040297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028561
protein coding gene Chr6:79836626-79843167 (-)
CAST/EiJ MGP_CASTEiJ_G0030024
protein coding gene Chr6:83851437-83857858 (-)
CBA/J MGP_CBAJ_G0030602
protein coding gene Chr6:90457702-90464344 (-)
DBA/2J MGP_DBA2J_G0030755
protein coding gene Chr6:80786714-80793356 (-)
FVB/NJ MGP_FVBNJ_G0030708
protein coding gene Chr6:79999653-80006322 (-)
LP/J MGP_LPJ_G0030834
protein coding gene Chr6:84700916-84707571 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030744
protein coding gene Chr6:94734117-94740786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031399
protein coding gene Chr6:83654958-83661399 (-)
PWK/PhJ MGP_PWKPhJ_G0029739
protein coding gene Chr6:79696825-79703363 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029567
protein coding gene Chr6:82479992-82486611 (-)
WSB/EiJ MGP_WSBEiJ_G0030105
protein coding gene Chr6:84077338-84083980 (-)



Homology
more
  • Human Ortholog
    CD207, CD207 molecule
  • Vertebrate Orthologs
    37
  • Human Ortholog
    CD207, CD207 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLEC4K
  • Links
    NCBI Gene ID: 50489
    neXtProt AC: NX_Q9UJ71
    UniProt: Q9UJ71

  • Chr Location
    2p13.3; chr2:70825248-70860787 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034783 Ensembl Gene Model | MGI Sequence Detail 6643 C57BL/6J ±  kb
transcript ENSMUST00000037882 Ensembl | MGI Sequence Detail 1522 Not Applicable  
polypeptide ENSMUSP00000040746 Ensembl | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    Genomic 2
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 118
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 91
  • Earliest
    J:59970 Valladeau J, et al., Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81
  • Latest
    J:263961 Tabib Y, et al., Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5736-E5745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory