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Cd207 Gene Detail
Summary
  • Symbol
    Cd207
  • Name
    CD207 antigen
  • Synonyms
    Langerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180021
    NCBI Gene: 246278
Location & Maps
more
  • Sequence Map
    Chr6:83671207-83677857 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6651 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CD207, CD207 molecule
  • Vertebrate Orthologs
    37
  • Human Ortholog
    CD207, CD207 molecule
    Orthology source: HomoloGene
  • Synonyms
    CLEC4K
  • Links
    NCBI Gene ID: 50489
    neXtProt AC: NX_Q9UJ71

  • Chr Location
    2p13; chr2:70825208-70836601 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CD207 associations

Human Disease Mouse Models
       Birbeck Granule Deficiency   OMIM: 613393
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 6 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Spontaneous
    1
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cd207
  • Incidental Mutations
Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 246278 NCBI Gene Model | MGI Sequence Detail 6651 C57BL/6J ±  kb
transcript NM_144943 RefSeq | MGI Sequence Detail 1530 C57BL/6  
polypeptide Q8VBX4 UniProt | EBI | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    84 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
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  • All nucleic 5
    Genomic 1
    cDNA 3
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 89
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 73
  • Earliest
    J:59970 Valladeau J, et al., Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81
  • Latest
    J:226199 Klenner L, et al., Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis. J Invest Dermatol. 2015 Nov;135(11):2676-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory