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Xpnpep1 Gene Detail
Summary
  • Symbol
    Xpnpep1
  • Name
    X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
  • Synonyms
    D230045I08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180003
    NCBI Gene: 170750
  • Gene Overview
    MyGene.info: XPNPEP1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:52943417-53040214 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 46.91 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1033 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180003
protein coding gene Chr19:52932227-53040214 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025242
protein coding gene Chr19:53044492-53151277 (-)
A/J MGP_AJ_G0025218
protein coding gene Chr19:50428071-50519356 (-)
AKR/J MGP_AKRJ_G0025187
protein coding gene Chr19:52031615-52126354 (-)
BALB/cJ MGP_BALBcJ_G0025213
protein coding gene Chr19:50517193-50606828 (-)
C3H/HeJ MGP_C3HHeJ_G0024973
protein coding gene Chr19:52219694-52315841 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025656
protein coding gene Chr19:54337643-54444328 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023068
protein coding gene Chr19:49431332-49521680 (-)
CAST/EiJ MGP_CASTEiJ_G0024438
protein coding gene Chr19:52178725-52277796 (-)
CBA/J MGP_CBAJ_G0024953
protein coding gene Chr19:56988925-57099780 (-)
DBA/2J MGP_DBA2J_G0025085
protein coding gene Chr19:50244005-50334963 (-)
FVB/NJ MGP_FVBNJ_G0025046
protein coding gene Chr19:49953104-50046147 (-)
LP/J MGP_LPJ_G0025171
protein coding gene Chr19:52909040-53006848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025077
protein coding gene Chr19:56488097-56584018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025714
protein coding gene Chr19:52205197-52304586 (-)
PWK/PhJ MGP_PWKPhJ_G0024186
protein coding gene Chr19:50160014-50249949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023989
protein coding gene Chr19:50891436-50988843 (-)
WSB/EiJ MGP_WSBEiJ_G0024508
protein coding gene Chr19:52343821-52439957 (-)



Homology
more
  • Human Ortholog
    XPNPEP1, X-prolyl aminopeptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    XPNPEP1, X-prolyl aminopeptidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APP1, SAMP, XPNPEP, XPNPEPL, XPNPEPL1
  • Links
    NCBI Gene ID: 7511
    neXtProt AC: NX_Q9NQW7
    UniProt: Q9NQW7

  • Chr Location
    10q25.1; chr10:109864766-109923553 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit pre and postnatal lethality, reduced male survival, growth retardation with decreased body weight, size and length, microcephaly and peptiduria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025027 Ensembl Gene Model | MGI Sequence Detail 96798 C57BL/6J ±  kb
transcript ENSMUST00000183108 Ensembl | MGI Sequence Detail 4078 Not Applicable  
polypeptide ENSMUSP00000138250 Ensembl | MGI Sequence Detail 666 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 213
    cDNA 213

    Microarray probesets 3
Other
Accession IDs
less
MGI:2444044
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:193753 Yoon SH, et al., Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1. Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):204-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory