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Catsper1 Gene Detail
Summary
  • Symbol
    Catsper1
  • Name
    cation channel, sperm associated 1
  • Synonyms
    KSper
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179947
    NCBI Gene: 225865
  • Gene Overview
    MyGene.info: CATSPER1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5335741-5344153 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.30 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179947
protein coding gene Chr19:5335602-5344281 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024698
protein coding gene Chr19:2291994-2300406 (+)
A/J MGP_AJ_G0024664
protein coding gene Chr19:2165180-2173607 (+)
AKR/J MGP_AKRJ_G0024637
protein coding gene Chr19:2229398-2237825 (+)
BALB/cJ MGP_BALBcJ_G0024664
protein coding gene Chr19:2164847-2173274 (+)
C3H/HeJ MGP_C3HHeJ_G0024432
protein coding gene Chr19:2234858-2243283 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025111
protein coding gene Chr19:2346525-2354947 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022541
protein coding gene Chr19:2075317-2084019 (+)
CAST/EiJ MGP_CASTEiJ_G0023904
protein coding gene Chr19:2265288-2273704 (+)
CBA/J MGP_CBAJ_G0024404
protein coding gene Chr19:2454937-2463352 (+)
DBA/2J MGP_DBA2J_G0024531
protein coding gene Chr19:2147366-2155791 (+)
FVB/NJ MGP_FVBNJ_G0024498
protein coding gene Chr19:2153686-2162609 (+)
LP/J MGP_LPJ_G0024617
protein coding gene Chr19:2273798-2282208 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024528
protein coding gene Chr19:2308481-2316908 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025159
protein coding gene Chr19:2230574-2238984 (+)
PWK/PhJ MGP_PWKPhJ_G0023650
protein coding gene Chr19:2185597-2194082 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023455
protein coding gene Chr19:2220577-2228870 (+)
WSB/EiJ MGP_WSBEiJ_G0023966
protein coding gene Chr19:2247604-2256028 (+)



Homology
more
  • Human Ortholog
    CATSPER1, cation channel sperm associated 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CATSPER1, cation channel sperm associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CATSPER, SPGF7
  • Links
    NCBI Gene ID: 117144
    neXtProt AC: NX_Q8NEC5
    UniProt: Q8NEC5

  • Chr Location
    11q13.1; chr11:66016752-66026518 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit sperm with markedly decreased motility that are unable to fertilize ova and lack a calcium ion influx response to cyclic-AMP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038498 Ensembl Gene Model | MGI Sequence Detail 8413 C57BL/6J ±  kb
    transcript ENSMUST00000043380 Ensembl | MGI Sequence Detail 2061 Not Applicable  
    polypeptide ENSMUSP00000045430 Ensembl | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      Genomic 2
      cDNA 1
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:72046 Ren D, et al., A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9
    • Latest
      J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory