About   Help   FAQ
Catsper1
Gene Detail
Symbol

Name
ID
Catsper1
cation channel, sperm associated 1
MGI:2179947
Synonyms
KSper
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.30 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:5335741-5344153 bp, + strand
From Ensembl annotation of GRCm38

  8413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CATSPER1
Gene Tree: Catsper1

Human
homologs
CATSPER1, cation channel, sperm associated 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 117144
neXtProt AC: NX_Q8NEC5

Human Synonyms: CATSPER, SPGF7

Human Chr (Location): 11q12.1; chr11:66016752-66026519 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CATSPER1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit sperm with markedly decreased motility that are unable to fertilize ova and lack a calcium ion influx response to cyclic-AMP.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component CatSper complex, cell projection, ...
Function calcium activated cation channel activity, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 2
cDNA source data(1)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(1) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000038498 (Evidence)
Entrez Gene 225865 (Evidence)
UniGene 87321
DFCI TC1600673
DoTS DT.55246576
NIA Mouse Gene Index U038727
Consensus CDS Project CCDS29456.1
International Mouse Phenotyping Consortium Status Catsper1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038498 Ensembl Gene Model | MGI Sequence Detail 8413 C57BL/6J ±  kb
transcript ENSMUST00000043380 Ensembl | MGI Sequence Detail 2061 Not Applicable 
polypeptide ENSMUSP00000045430 Ensembl | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000669 cation channel sperm-associated protein 1
References
(Earliest) J:72046 Ren D, et al., A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9
(Latest) J:218100 Chavez JC, et al., SLO3 K+ channels control calcium entry through CATSPER channels in sperm. J Biol Chem. 2014 Nov 14;289(46):32266-75
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory