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Catsper1
Gene Detail
Symbol

Name
ID
Catsper1
cation channel, sperm associated 1
MGI:2179947
Synonyms
KSper
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.30 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:5335741-5344153 bp, + strand
From Ensembl annotation of GRCm38

  8413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Catsper1

Human
homologs
Human Homolog CATSPER1, cation channel, sperm associated 1
NCBI Gene ID 117144
neXtProt AC  NX_Q8NEC5
Human Synonyms  CATSPER, SPGF7
Human Chr (Location)  11q12.1; chr11:66016752-66026517 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CATSPER1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit sperm with markedly decreased motility that are unable to fertilize ova and lack a calcium ion influx response to cyclic-AMP.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component CatSper complex, cell projection, ...
Function calcium activated cation channel activity, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 2
cDNA source data(1)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(1) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000038498 (Evidence)
Entrez Gene225865 (Evidence)
UniGene87321
DFCITC1600673
DoTSDT.55246576
NIA Mouse Gene IndexU038727
Consensus CDS ProjectCCDS29456.1
International Mouse Knockout Project StatusCatsper1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038498 Ensembl Gene Model | MGI Sequence Detail 8413 C57BL/6J ±  kb
transcript ENSMUST00000043380 Ensembl | MGI Sequence Detail 2061 Not Applicable 
polypeptide ENSMUSP00000045430 Ensembl | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000669 cation channel sperm-associated protein 1
References
(Earliest) J:72046 Ren D, et al., A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9
(Latest) J:214399 Chung JJ, et al., Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014 May 8;157(4):808-22
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory