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Mpst Gene Detail
Summary
  • Symbol
    Mpst
  • Name
    mercaptopyruvate sulfurtransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179733
    NCBI Gene: 246221
  • Gene Overview
    MyGene.info: MPST
Location & Maps
more
  • Sequence Map
    Chr15:78406712-78414002 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7291 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.47 cM, cytoband E2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MPST, mercaptopyruvate sulfurtransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPST, mercaptopyruvate sulfurtransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MST, TST2, TUM1
  • Links
    NCBI Gene ID: 4357
    neXtProt AC: NX_P25325

  • Chr Location
    22q12.3; chr22:37019642-37029822 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31942
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MPST
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Mpst
  • Incidental Mutations
Mice heterozygous for a knock-out allele exhibit reduced male fertility. Mice homozygous for a knock-out allele exhibit normal fertility but increased anxiety-related behaviors and increased serotonin metabolite levels in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071711 Ensembl Gene Model | MGI Sequence Detail 7291 C57BL/6J ±  kb
transcript ENSMUST00000169133 Ensembl | MGI Sequence Detail 1309 Not Applicable  
polypeptide ENSMUSP00000128075 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Diseases 1
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:207803 Nagahara N, et al., Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria. Sci Rep. 2013;3:1986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory