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Vwa1
Gene Detail
Symbol

Name
ID
Vwa1
von Willebrand factor A domain containing 1
MGI:2179729
Synonyms
4932416A11Rik, WARP
Feature Type
protein coding gene
Genetic Map
Chromosome 4
87.31 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:155768149-155774698 bp, - strand
From VEGA annotation of GRCm38

  6550 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11270  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VWA1
Gene Tree: Vwa1

Human
homologs
VWA1, von Willebrand factor A domain containing 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64856
neXtProt AC: NX_Q6PCB0

Human Synonyms: WARP

Human Chr (Location): 1p36.33; chr1:1435523-1442882 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit abnormal motor coordination/balance, increased thermal nociceptive threshold, and altered peripheral nerve structure and function.
 
Interactions
Vwa1 interacts with 184 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process behavioral response to pain, extracellular matrix organization
Component basement membrane, extracellular exosome, ...
Function identical protein binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (5)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vwa1    NEW 
Molecular
reagents
All nucleic(35) cDNA(35)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010849 (Evidence)
Ensembl Gene Model ENSMUSG00000042116 (Evidence)
Entrez Gene 246228 (Evidence)
UniGene 26515
DFCI TC1616672, TC1577561
DoTS DT.101333923, DT.101371455, DT.94211237
NIA Mouse Gene Index U025879
Consensus CDS Project CCDS19039.1
International Mouse Phenotyping Consortium Status Vwa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010849 VEGA Gene Model | MGI Sequence Detail 6550 C57BL/6J ±  kb
transcript OTTMUST00000025385 VEGA | MGI Sequence Detail 3623 Not Applicable 
polypeptide OTTMUSP00000011639 VEGA | MGI Sequence Detail 415 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000017361 von Willebrand factor A domain-containing protein 1
References
(Earliest) J:76165 Fitzgerald J, et al., WARP is a new member of the von Willebrand factor A-domain superfamily of extracellular matrix proteins. FEBS Lett. 2002 Apr 24;517(1-3):61-6
(Latest) J:195830 Hansen U, et al., WARP interacts with collagen VI-containing microfibrils in the pericellular matrix of human chondrocytes. PLoS One. 2012;7(12):e52793
All references(32)
Other
accession IDs
MGI:2444699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory