Nlgn1
Gene Detail

Symbol Name ID

Nlgn1 neuroligin 1 MGI:2179435

Synonyms

6330415N05Rik, mKIAA1070, NL1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

10.38 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:25431811-26133734 bp, - strand From Ensembl annotation of GRCm38   701924 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nlgn1

Human homologs

Human Homolog		NLGN1, neuroligin 1
NCBI Gene ID		22871
neXtProt AC		NX_Q8N2Q7
Human Synonyms		NL1
Human Chr (Location)		3q26.31; chr3:173116244-174001116 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele are viable and fertile but display impaired NMDA receptor-mediated synaptic transmission onto CA1 pyramidal cells.

 

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering, calcium-dependent cell-cell adhesion, ...
Component	cell junction, cell surface, ...
Function	cell adhesion molecule binding, neurexin family protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000063887 (Evidence)
Entrez Gene	192167 (Evidence)
NIA Mouse Gene Index	U023893
PDB	3B3Q
Consensus CDS Project	CCDS17268.1, CCDS50874.1
International Mouse Knockout Project Status	Nlgn1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000063887	Ensembl Gene Model | MGI Sequence Detail	701924	C57BL/6J
transcript	ENSMUST00000075054	Ensembl | MGI Sequence Detail	4359	Not Applicable
polypeptide	ENSMUSP00000074565	Ensembl | MGI Sequence Detail	843	Not Applicable

All sequences(29) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(3452 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002018	Carboxylesterase, type B
InterPro	IPR019819	Carboxylesterase type B, conserved site
InterPro	IPR000460	Neuroligin
Protein Ontology	PR:000011254	neuroligin-1

References

(Earliest) J:116404 Scheiffele P, et al., Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell. 2000 Jun 9;101(6):657-69
(Latest) J:193528 Budreck EC, et al., Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):725-30
All references(60)

Other accession IDs

MGI:1918002, MGI:2140030