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Nlgn1
Gene Detail
Symbol

Name
ID
Nlgn1
neuroligin 1
MGI:2179435
Synonyms
6330415N05Rik, mKIAA1070, NL1, Nlg1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
10.38 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:25426215-26332460 bp, - strand
From VEGA annotation of GRCm38

  906246 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NLGN1
Gene Tree: Nlgn1

Human
homologs
NLGN1, neuroligin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 22871
neXtProt AC: NX_Q8N2Q7

Human Synonyms: NL1

Human Chr (Location): 3q26.31; chr3:173396490-174286644 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable and fertile but display impaired NMDA receptor-mediated synaptic transmission onto CA1 pyramidal cells.
 
Interactions
Nlgn1 interacts with 382 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (17)    Tissues (11)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 6
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nlgn1 ; ZFIN nlgn1    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051161 (Evidence)
Ensembl Gene Model ENSMUSG00000063887 (Evidence)
Entrez Gene 192167 (Evidence)
NIA Mouse Gene Index U023893, U256097
PDB 3B3Q
Consensus CDS Project CCDS17268.1, CCDS50874.1
International Mouse Phenotyping Consortium Status Nlgn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051161 VEGA Gene Model | MGI Sequence Detail 906246 C57BL/6J ±  kb
transcript OTTMUST00000129614 VEGA | MGI Sequence Detail 11807 Not Applicable 
polypeptide OTTMUSP00000069614 VEGA | MGI Sequence Detail 843 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(30) UniProt(6)
Polymorphisms
SNPs within 2kb(4402 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4416)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000460 Neuroligin
Protein Ontology PR:000011254 neuroligin-1
References
(Earliest) J:116404 Scheiffele P, et al., Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell. 2000 Jun 9;101(6):657-69
(Latest) J:221434 Belanger-Nelson E, et al., Brain hemodynamic response to somatosensory stimulation in Neuroligin-1 knockout mice. Neuroscience. 2015 Mar 19;289:242-50
All references(73)
Other
accession IDs
MGI:1918002, MGI:2140030

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory