About   Help   FAQ
Nlgn1 Gene Detail
Summary
  • Symbol
    Nlgn1
  • Name
    neuroligin 1
  • Synonyms
    6330415N05Rik, mKIAA1070, NL1, Nlg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179435
    NCBI Gene: 192167
  • Gene Overview
    MyGene.info: NLGN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:25426215-26332460 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      906246 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.38 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NLGN1, neuroligin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NLGN1, neuroligin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NL1
  • Links
    NCBI Gene ID: 22871
    neXtProt AC: NX_Q8N2Q7
    UniProt: Q8N2Q7

  • Chr Location
    3q26.31; chr3:173395899-174291287 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56690
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NLGN1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile but display impaired NMDA receptor-mediated synaptic transmission onto CA1 pyramidal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051161 VEGA Gene Model | MGI Sequence Detail 906246 C57BL/6J ±  kb
    transcript OTTMUST00000129614 VEGA | MGI Sequence Detail 11807 Not Applicable  
    polypeptide OTTMUSP00000069614 VEGA | MGI Sequence Detail 843 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4369 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918002, MGI:2140030
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 29
      Phenotypes 29
    • Earliest
      J:116404 Scheiffele P, et al., Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell. 2000 Jun 9;101(6):657-69
    • Latest
      J:251121 Molumby MJ, et al., gamma-Protocadherins Interact with Neuroligin-1 and Negatively Regulate Dendritic Spine Morphogenesis. Cell Rep. 2017 Mar 14;18(11):2702-2714

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory