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Nlgn1
Gene Detail
 Symbol
Name
ID
Nlgn1
neuroligin 1
MGI:2179435
Synonyms 6330415N05Rik, mKIAA1070, NL1, Nlg1
Feature Type protein coding gene
Genetic Map
Chromosome 3
10.38 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:25431811-26133734 bp, - strand
From Ensembl annotation of GRCm38

  701924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nlgn1

Human
homologs
Human Homolog NLGN1, neuroligin 1
NCBI Gene ID 22871
neXtProt AC  NX_Q8N2Q7
Human Synonyms  NL1
Human Chr (Location)  3q26.31; chr3:173397780-174286644 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile but display impaired NMDA receptor-mediated synaptic transmission onto CA1 pyramidal cells.
 
Interactions
Nlgn1 interacts with 383 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering, calcium-dependent cell-cell adhesion, ...
Component cell junction, cell surface, ...
Function cell adhesion molecule binding, neurexin family protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (17)    Tissues (11)    Images (14)
Theiler Stages: 21, 23, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 6
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000063887 (Evidence)
Entrez Gene192167 (Evidence)
NIA Mouse Gene IndexU023893, U256097
PDB3B3Q
Consensus CDS ProjectCCDS17268.1, CCDS50874.1
International Mouse Knockout Project StatusNlgn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063887 Ensembl Gene Model | MGI Sequence Detail 701924 C57BL/6J ±  kb
transcript ENSMUST00000075054 Ensembl | MGI Sequence Detail 4359 Not Applicable 
polypeptide ENSMUSP00000074565 Ensembl | MGI Sequence Detail 843 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(28) UniProt(6)
Polymorphisms SNPs within 2kb(4342 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4356)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR000460 Neuroligin
Protein Ontology PR:000011254 neuroligin-1
References (Earliest) J:116404 Scheiffele P, et al., Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell. 2000 Jun 9;101(6):657-69
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(71)
Other
accession IDs
MGI:1918002, MGI:2140030

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory