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Mycbp2
Gene Detail
Symbol

Name
ID
Mycbp2
MYC binding protein 2
MGI:2179432
Synonyms
C130061D10Rik, Pam, Phr1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
51.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:103113411-103346814 bp, - strand
From VEGA annotation of GRCm38

  233404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9005  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: MYCBP2
Gene Tree: Mycbp2

Human
homologs
MYCBP2, MYC binding protein 2, E3 ubiquitin protein ligase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23077
neXtProt AC: NX_O75592

Human Synonyms: PAM

Human Chr (Location): 13q22; chr13:77044657-77327042 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(4) Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance.
 
Phenotype Images(1)
Interactions
Mycbp2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (141)    Tissues (32)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mycbp2 ; ZFIN mycbp2    NEW 
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000034690 (Evidence)
Ensembl Gene Model ENSMUSG00000033004 (Evidence)
Entrez Gene 105689 (Evidence)
DFCI TC1652317, TC1608463, TC1707600, TC1598823, TC1661064, TC1574964
NIA Mouse Gene Index U035875
EC 6.3.2.-
PDB 3GBW, 3HWJ
Consensus CDS Project CCDS49559.1
International Mouse Phenotyping Consortium Status Mycbp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034690 VEGA Gene Model | MGI Sequence Detail 233404 C57BL/6J ±  kb
transcript OTTMUST00000088082 VEGA | MGI Sequence Detail 15233 Not Applicable 
polypeptide OTTMUSP00000047986 VEGA | MGI Sequence Detail 4746 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(36) UniProt(5)
Polymorphisms
SNPs within 2kb(845 from dbSNP Build 137)    SNPs within 2kb including multiple locations(851)
Protein-related
information
ResourceIDDescription
InterPro IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
InterPro IPR027047 E3 ubiquitin-protein ligase Highwire/Pam/Rpm-1
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR012983 PHR
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR003646 SH3-like domain, bacterial
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000030251 E3 ubiquitin-protein ligase MYCBP2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:201577 Huntwork-Rodriguez S, et al., JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol. 2013 Sep 2;202(5):747-63
All references(49)
Other
accession IDs
MGI:2145747, MGI:2145797, MGI:2145828, MGI:2145882, MGI:2444179

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory