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Mycbp2 Gene Detail
Summary
  • Symbol
    Mycbp2
  • Name
    MYC binding protein 2, E3 ubiquitin protein ligase
  • Synonyms
    C130061D10Rik, Pam, Phr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179432
    NCBI Gene: 105689
  • Gene Overview
    MyGene.info: MYCBP2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:103113411-103346800 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 51.79 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    834 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179432
protein coding gene Chr14:103113411-103346814 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021630
protein coding gene Chr14:99603713-99856841 (-)
A/J MGP_AJ_G0021588
protein coding gene Chr14:96314549-96547365 (-)
AKR/J MGP_AKRJ_G0021564
protein coding gene Chr14:99199188-99437514 (-)
BALB/cJ MGP_BALBcJ_G0021594
protein coding gene Chr14:96660808-96890648 (-)
C3H/HeJ MGP_C3HHeJ_G0021372
protein coding gene Chr14:99096524-99333549 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022034
protein coding gene Chr14:103632814-103887323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019574
protein coding gene Chr14:93181061-93418544 (-)
CAST/EiJ MGP_CASTEiJ_G0020889
protein coding gene Chr14:96434940-96674557 (-)
CBA/J MGP_CBAJ_G0021340
protein coding gene Chr14:107339706-107602885 (-)
DBA/2J MGP_DBA2J_G0021464
protein coding gene Chr14:95808010-96043503 (-)
FVB/NJ MGP_FVBNJ_G0021441
protein coding gene Chr14:94783569-95008020 (-)
LP/J MGP_LPJ_G0021532
protein coding gene Chr14:100427199-100671825 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021468
protein coding gene Chr14:110190187-110469546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022057
protein coding gene Chr14:98719447-98966819 (-)
PWK/PhJ MGP_PWKPhJ_G0020632
protein coding gene Chr14:92803725-93039724 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020470
protein coding gene Chr14:94758089-94997262 (-)
WSB/EiJ MGP_WSBEiJ_G0020942
protein coding gene Chr14:99369516-99625056 (-)



Homology
more
  • Human Ortholog
    MYCBP2, MYC binding protein 2, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYCBP2, MYC binding protein 2, E3 ubiquitin protein ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Myc-bp2, PAM, Phr
  • Links
    NCBI Gene ID: 23077
    neXtProt AC: NX_O75592
    UniProt: O75592

  • Chr Location
    13q22.3; chr13:77044657-77327066 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 6 alleles in 9 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105689 NCBI Gene Model | MGI Sequence Detail 233390 C57BL/6J ±  kb
    transcript NM_207215 RefSeq | MGI Sequence Detail 15269 C57BL/6  
    polypeptide Q7TPH6 UniProt | EBI | MGI Sequence Detail 4749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2145747, MGI:2145797, MGI:2145828, MGI:2145882, MGI:2444179
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:239715 Galazo MJ, et al., Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory