Prpf8
Gene Detail

Symbol Name ID

Prpf8 pre-mRNA processing factor 8 MGI:2179381

Synonyms

D11Bwg0410e, DBF3/PRP8, Prp8, Sfprp8l

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:75486816-75509449 bp, + strand From VEGA annotation of GRCm38   22634 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4706  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prpf8

Human homologs

Human Homolog		PRPF8, PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
NCBI Gene ID		10594
neXtProt AC		NX_Q6P2Q9
Human Synonyms		HPRP8, PRP8, PRPC8, RP13
Human Chr (Location)		17p13.3; chr17:1553923-1588176 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRPF8

Alleles and phenotypes

All alleles(17) : Targeted(3) Gene trapped(14)
Human Diseases Modeled Using Mouse Prpf8 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	mRNA processing, mRNA splicing, via spliceosome, ...
Component	catalytic step 2 spliceosome, nucleus, ...
Function	RNA binding, U5 snRNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (35)    Images (3)
Theiler Stages: 15, 19, 21, 23, 25, 28

Assay Type	Results
RNA in situ	23
Northern blot	13
RT-PCR	2

cDNA source data(530)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(534) Genomic(2) cDNA(530) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006208 (Evidence)
Ensembl Gene Model	ENSMUSG00000020850 (Evidence)
Entrez Gene	192159 (Evidence)
UniGene	3757
DFCI	TC1573109, TC1651564
DoTS	DT.102540354, DT.103582966, DT.110502006, DT.494863, DT.94410792, DT.99861991
NIA Mouse Gene Index	U012950
Consensus CDS Project	CCDS25048.1
International Mouse Knockout Project Status	Prpf8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006208	VEGA Gene Model | MGI Sequence Detail	22634	C57BL/6J
transcript	OTTMUST00000014003	VEGA | MGI Sequence Detail	7442	Not Applicable
polypeptide	OTTMUSP00000006505	VEGA | MGI Sequence Detail	2335	Not Applicable

All sequences(56) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000555	JAB1/Mov34/MPN/PAD-1
InterPro	IPR012591	Pre-mRNA-processing-splicing factor 8
InterPro	IPR019581	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
InterPro	IPR019580	Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
InterPro	IPR012592	PROCN
InterPro	IPR012984	PRO, C-terminal
InterPro	IPR021983	PRP8 domain IV core
InterPro	IPR019582	RNA recognition motif, spliceosomal PrP8
Protein Ontology	PR:000013288	pre-mRNA-processing-splicing factor 8

References

(Earliest) J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)

Other accession IDs

MGD-MRK-34064, MGI:106371, MGI:1194893, MGI:2144394