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Mvd Gene Detail
Summary
  • Symbol
    Mvd
  • Name
    mevalonate (diphospho) decarboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179327
    NCBI Gene: 192156
Location & Maps
more
  • Sequence Map
    Chr8:122433596-122443422 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9827 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 71.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MVD, mevalonate diphosphate decarboxylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MVD, mevalonate diphosphate decarboxylase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FP17780, MDDase, MPD, POROK7
  • Links
    NCBI Gene ID: 4597
    neXtProt AC: NX_P53602

  • Chr Location
    16q24.3; chr16:88651935-88663157 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MVD associations

Human Disease Mouse Models
       Porokeratosis 7, Multiple Types; POROK7   OMIM: 614714
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    11
  • Gene trapped
    9
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 192156 NCBI Gene Model | MGI Sequence Detail 9827 C57BL/6J ±  kb
transcript NR_028354 RefSeq | MGI Sequence Detail 1864 C57BL/6  
polypeptide Q99JF5 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    119 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010785 diphosphomevalonate decarboxylase
  • PDB
  • EC
  • InterPro Domains
    IPR029765 Diphosphomevalonate decarboxylase
    IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase
    IPR013750 GHMP kinase, C-terminal domain
    IPR006204 GHMP kinase N-terminal domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Molecular
Reagents
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  • All nucleic 60
    cDNA 59
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2142855
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:224387 Sisecioglu M, et al., A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. J Lipid Res. 2015 Aug;56(8):1551-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory