About   Help   FAQ
Oxr1 Gene Detail
Summary
  • Symbol
    Oxr1
  • Name
    oxidation resistance 1
  • Synonyms
    2210416C20Rik, C7, C7B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179326
    NCBI Gene: 170719
  • Gene Overview
    MyGene.info: OXR1
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:41447482-41861048 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.06 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4075 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179326
protein coding gene Chr15:41447425-41861051 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021821
protein coding gene Chr15:39957544-40413233 (+)
A/J MGP_AJ_G0021781
protein coding gene Chr15:38416827-38842622 (+)
AKR/J MGP_AKRJ_G0021762
protein coding gene Chr15:39589805-40031721 (+)
BALB/cJ MGP_BALBcJ_G0021788
protein coding gene Chr15:38504095-38931217 (+)
C3H/HeJ MGP_C3HHeJ_G0021562
protein coding gene Chr15:39499014-39921322 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022227
protein coding gene Chr15:41503525-41960102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019764
protein coding gene Chr15:36106807-36514673 (+)
CAST/EiJ MGP_CASTEiJ_G0021079
protein coding gene Chr15:39983016-40423382 (+)
CBA/J MGP_CBAJ_G0021531
protein coding gene Chr15:42934221-43413993 (+)
DBA/2J MGP_DBA2J_G0021655
protein coding gene Chr15:38263195-38686926 (+)
FVB/NJ MGP_FVBNJ_G0021633
protein coding gene Chr15:37602988-38016569 (+)
LP/J MGP_LPJ_G0021725
protein coding gene Chr15:39769633-40218280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021657
protein coding gene Chr15:45977393-46453360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022250
protein coding gene Chr15:39763989-40201349 (+)
PWK/PhJ MGP_PWKPhJ_G0020824
protein coding gene Chr15:38304442-38731579 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020661
protein coding gene Chr15:39384953-39846840 (+)
WSB/EiJ MGP_WSBEiJ_G0021134
protein coding gene Chr15:39663257-40108670 (+)



Homology
more
  • Human Ortholog
    OXR1, oxidation resistance 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OXR1, oxidation resistance 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Nbla00307, TLDC3
  • Links
    NCBI Gene ID: 55074
    neXtProt AC: NX_Q8N573
    UniProt: Q8N573

  • Chr Location
    8q23.1; chr8:106270178-106752694 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 24993
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OXR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in progressive cerebellar neurodegeneration and ataxia, increased apoptosis in the cerebellar granule cell layer, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022307 Ensembl Gene Model | MGI Sequence Detail 413567 C57BL/6J ±  kb
    transcript ENSMUST00000110297 Ensembl | MGI Sequence Detail 4599 Not Applicable  
    polypeptide ENSMUSP00000105926 Ensembl | MGI Sequence Detail 866 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 12
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922080
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory