Rttn
Gene Detail

Symbol Name ID

Rttn rotatin MGI:2179288

Synonyms

4921538A15Rik, C530033I08Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

58.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:88971790-89131013 bp, + strand From Ensembl annotation of GRCm38   159224 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:65275  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rttn

Human homologs

Human Homolog		RTTN, rotatin
NCBI Gene ID		25914
neXtProt AC		NX_Q86VV8
Human Chr (Location)		18q22.2; chr18:67671040-67872962 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RTTN

Alleles and phenotypes

All alleles(15) : Targeted(2) Gene trapped(12) Transgenic(1)
 

Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart.

 

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	determination of left/right symmetry, multicellular organismal development
Component	cilium basal body, integral to membrane

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 15

Assay Type	Results
RT-PCR	2

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000023066 (Evidence)
Entrez Gene	246102 (Evidence)
UniGene	772
DFCI	TC1584947, TC1589865, TC1593363, TC1597569, TC1600586, TC1747426
DoTS	DT.101364242, DT.110784464, DT.91373198, DT.94174428, DT.99849738, DT.99856069
NIA Mouse Gene Index	U043694
Consensus CDS Project	CCDS29390.1
International Mouse Knockout Project Status	Rttn

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023066	Ensembl Gene Model | MGI Sequence Detail	159224	C57BL/6J
transcript	ENSMUST00000023828	Ensembl | MGI Sequence Detail	7268	Not Applicable
polypeptide	ENSMUSP00000023828	Ensembl | MGI Sequence Detail	2226	Not Applicable

All sequences(33) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(399 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
Protein Ontology	PR:000014357	rotatin

References

(Earliest) J:47980 Stoykova A, et al., Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system. Dev Dyn. 1998 Jun;212(2):198-213
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Other accession IDs

MGI:1918209, MGI:2147258, MGI:2441910