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Plxna4 Gene Detail
Summary
  • Symbol
    Plxna4
  • Name
    plexin A4
  • Synonyms
    Plxa4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179061
    NCBI Gene: 243743
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:32121478-32565127 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.90 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3919 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179061
 protein coding gene Chr6:32121203-32565127 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030551
 protein coding gene Chr6:30127855-30588460 (-)
A/J MGP_AJ_G0030524
 protein coding gene Chr6:28811796-29270472 (-)
AKR/J MGP_AKRJ_G0030451
 protein coding gene Chr6:29799134-30257918 (-)
BALB/cJ MGP_BALBcJ_G0030534
 protein coding gene Chr6:28953596-29400654 (-)
C3H/HeJ MGP_C3HHeJ_G0030247
 protein coding gene Chr6:29788312-30240921 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030988
 protein coding gene Chr6:30928444-31386555 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028199
 protein coding gene Chr6:26968004-27419984 (-)
CAST/EiJ MGP_CASTEiJ_G0029649
 protein coding gene Chr6:29577604-30037065 (-)
CBA/J MGP_CBAJ_G0030225
 protein coding gene Chr6:32121996-32582759 (-)
DBA/2J MGP_DBA2J_G0030369
 protein coding gene Chr6:28726380-29170845 (-)
FVB/NJ MGP_FVBNJ_G0030323
 protein coding gene Chr6:28516287-28967280 (-)
LP/J MGP_LPJ_G0030456
 protein coding gene Chr6:30277450-30737946 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030359
 protein coding gene Chr6:34495459-34948635 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031018
 protein coding gene Chr6:29683544-30135052 (-)
PWK/PhJ MGP_PWKPhJ_G0029363
 protein coding gene Chr6:28307175-28760332 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029199
 protein coding gene Chr6:29356473-29833997 (-)
WSB/EiJ MGP_WSBEiJ_G0029725
 protein coding gene Chr6:29609867-30064355 (-)



Homology
more
  • Human Ortholog
    PLXNA4, plexin A4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNA4, plexin A4
  • Synonyms
    FAYV2820, PLEXA4, PLXNA4A, PLXNA4B, PRO34003
  • Links
    NCBI Gene ID: 91584
    neXtProt AC: NX_Q9HCM2
    UniProt: Q9HCM2

  • Chr Location
    7q32.3; chr7:132123340-132648688 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit defective trajecotory and projection of peripheral sensory axons and sympathetic ganglion axons and the formation of the anterior commissure and the barrels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    118
  • cDNA Data
    44
  • Literature Summary
    54
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243743 NCBI Gene Model | MGI Sequence Detail 443650 C57BL/6J ±  kb
    transcript NM_175750 RefSeq | MGI Sequence Detail 12602 C57BL/6  
    polypeptide Q80UG2 UniProt | EBI | MGI Sequence Detail 1893 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 45
      Primer pair 4
      Other 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 54
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:72426 Cheng HJ, et al., Plexin-a3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Neuron. 2001 Oct 25;32(2):249-63
    • Latest
      J:343285 Lettieri A, et al., SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability. Nat Commun. 2023 Dec 7;14(1):8097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory