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Wipf1 Gene Detail
Summary
  • Symbol
    Wipf1
  • Name
    WAS/WASL interacting protein family, member 1
  • Synonyms
    D2Ertd120e, Waspip, WIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178801
    NCBI Gene: 215280
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73259954-73359831 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178801
 protein coding gene Chr2:73259954-73360078 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025838
 protein coding gene Chr2:73704430-73808643 (-)
A/J MGP_AJ_G0025816
 protein coding gene Chr2:70809295-70915322 (-)
AKR/J MGP_AKRJ_G0025784
 protein coding gene Chr2:72755793-72859604 (-)
BALB/cJ MGP_BALBcJ_G0025810
 protein coding gene Chr2:71001101-71102207 (-)
C3H/HeJ MGP_C3HHeJ_G0025570
 protein coding gene Chr2:72939932-73042746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026257
 protein coding gene Chr2:75899167-76001480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023660
 protein coding gene Chr2:68011867-68110233 (-)
CAST/EiJ MGP_CASTEiJ_G0025034
 protein coding gene Chr2:73208940-73316501 (-)
CBA/J MGP_CBAJ_G0025551
 protein coding gene Chr2:78660674-78776202 (-)
DBA/2J MGP_DBA2J_G0025682
 protein coding gene Chr2:70409971-70510077 (-)
FVB/NJ MGP_FVBNJ_G0025644
 protein coding gene Chr2:69822551-69923878 (-)
LP/J MGP_LPJ_G0025770
 protein coding gene Chr2:73582090-73684286 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025675
 protein coding gene Chr2:80598525-80699672 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026314
 protein coding gene Chr2:72839030-72944920 (-)
PWK/PhJ MGP_PWKPhJ_G0024775
 protein coding gene Chr2:70330469-70435489 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024583
 protein coding gene Chr2:73073688-73179231 (-)
WSB/EiJ MGP_WSBEiJ_G0025102
 protein coding gene Chr2:73289842-73396237 (-)



Homology
more
  • Human Ortholog
    WIPF1, WAS/WASL interacting protein family member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WIPF1, WAS/WASL interacting protein family member 1
  • Synonyms
    PRPL-2, WAS2, WASPIP, WIP
  • Links
    NCBI Gene ID: 7456
    UniProt: O43516

  • Chr Location
    2q31.1; chr2:174559572-174682916 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 1 allele in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    89
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215280 NCBI Gene Model | MGI Sequence Detail 99878 C57BL/6J ±  kb
    transcript NM_001289722 RefSeq | MGI Sequence Detail 4486 ZRU/MplStud  
    polypeptide Q8K1I7 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 89
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1196354, MGI:2138838
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:270863 Keppler SJ, et al., The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses. Cell Rep. 2018 Jul 17;24(3):619-629
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory