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Wipf1
Gene Detail
Symbol

Name
ID
Wipf1
WAS/WASL interacting protein family, member 1
MGI:2178801
Synonyms
D2Ertd120e, Waspip, WIP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
43.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:73429610-73529734 bp, - strand
From VEGA annotation of GRCm38

  100125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: WAS/WASL-interacting protein family member
Gene Tree: Wipf1
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(13) Targeted(7)
Genomic Mutations involving Wipf1 (4)
Incidental mutations (data from APF )
 
Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.
 
Interactions
Wipf1 interacts with 351 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process actin filament-based movement, actin polymerization or depolymerization, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(88)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(89) cDNA(88) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013425 (Evidence)
Ensembl Gene ModelENSMUSG00000075284 (Evidence)
Entrez Gene215280, 102632695
UniGene223504
DFCITC1575670, TC1610800
DoTSDT.101250778, DT.535332, DT.101355936
NIA Mouse Gene IndexU022746
Consensus CDS ProjectCCDS16131.1
International Mouse Knockout Project StatusWipf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013425 VEGA Gene Model | MGI Sequence Detail 100125 C57BL/6J ±  kb
transcript OTTMUST00000032436 VEGA | MGI Sequence Detail 4728 Not Applicable 
polypeptide OTTMUSP00000014408 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(52) UniProt(7)
Polymorphisms
SNPs within 2kb(678 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017422 WAS/WASL-interacting protein family member 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199715 Donnelly SK, et al., WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization. Curr Biol. 2013 Jun 3;23(11):999-1006
All references(52)
Other
accession IDs
MGI:1196354, MGI:2138838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory