Wipf1 Gene Detail

Summary

• Symbol
  Wipf1
• Name
  WAS/WASL interacting protein family, member 1
• Synonyms
  D2Ertd120e, Waspip, WIP

• Feature Type
  protein coding gene
• IDs
  MGI:2178801
  NCBI Gene: 215280
• Gene Overview
  MyGene.info: WIPF1

Location & Maps

• Sequence Map
  Chr2:73429610-73529734 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    100125 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 43.68 cM
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  WIPF1, WAS/WASL interacting protein family member 1

• Vertebrate Orthologs
  8

• Human Ortholog
  WIPF1, WAS/WASL interacting protein family member 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  PRPL-2, WAS2, WASPIP, WIP
• Links
  HGNC:12736

  NCBI Gene ID: 7456

  neXtProt AC: NX_O43516

  
  
• Chr Location
  2q31.1; chr2:174559574-174682899 (-)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 86891
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken
  
• HCOP
  human homology predictions: WIPF1
• Protein SuperFamily
  WAS/WASL-interacting protein family member
• Gene Tree
  Wipf1
  

Human Diseases

• Diseases
  1 with human WIPF1 associations

				Human Disease	Mouse Models
				Wiskott-Aldrich Syndrome 2; WAS2   OMIM: 614493

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  30 phenotype references
  

• All Mutations and Alleles
  24
• Chemically induced (other)
  1
• Gene trapped
  13
• Targeted
  10
• Genomic Mutations
  7 involving Wipf1
• Incidental Mutations
  APF , CvDC

Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  7

• External Resources
  FuncBase

Expression

• cDNA Data
  88
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase wipf1

Interactions

• Wipf1 interacts with 350 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  60
• RefSeq
  12
• UniProt
  4
• CCDS
  CCDS16131.1
• UniGene
  223504

• VEGA
  OTTMUSG00000013425 (Evidence)
• Ensembl
  ENSMUSG00000075284 (Evidence)
• NCBI Gene
  215280

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000013425	VEGA Gene Model | MGI Sequence Detail	100125	C57BL/6J
transcript	OTTMUST00000032438	VEGA | MGI Sequence Detail	2039	Not Applicable
polypeptide	OTTMUSP00000014410	VEGA | MGI Sequence Detail	493	Not Applicable

Polymorphisms

• SNPs within 2kb
  678 from dbSNP Build 142

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000017422 WAS/WASL-interacting protein family member 1
• InterPro Domains
  IPR028295 WAS/WASL-interacting protein family member 1
  IPR003124 WH2 domain

Molecular
Reagents

• All nucleic 89

  cDNA 88

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1196354, MGI:2138838

References

• Summaries
  All 54

  Developmental Gene Expression 1

  Gene Ontology 7

  Phenotypes 30
• Earliest
  J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
• Latest
  J:233861 Keppler SJ, et al., Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. Immunity. 2015 Oct 20;43(4):660-73