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Wipf1 Gene Detail
Summary
  • Symbol
    Wipf1
  • Name
    WAS/WASL interacting protein family, member 1
  • Synonyms
    D2Ertd120e, Waspip, WIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178801
    NCBI Gene: 215280
Location & Maps
more
  • Sequence Map
    Chr2:73429610-73529734 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100125 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WIPF1, WAS/WASL interacting protein family member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WIPF1, WAS/WASL interacting protein family member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PRPL-2, WAS2, WASPIP, WIP
  • Links
    NCBI Gene ID: 7456
    neXtProt AC: NX_O43516

  • Chr Location
    2q31.1; chr2:174559574-174682899 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human WIPF1 associations

Human Disease Mouse Models
       Wiskott-Aldrich Syndrome 2; WAS2   OMIM: 614493
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Targeted
    9
  • Genomic Mutations
    7 involving Wipf1
  • Incidental Mutations
    APF , CvDC
Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013425 VEGA Gene Model | MGI Sequence Detail 100125 C57BL/6J ±  kb
transcript OTTMUST00000032436 VEGA | MGI Sequence Detail 4728 Not Applicable  
polypeptide OTTMUSP00000014408 VEGA | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    678 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017422 WAS/WASL-interacting protein family member 1
  • InterPro Domains
    IPR028295 WAS/WASL-interacting protein family member 1
    IPR003124 WH2 domain
Molecular
Reagents
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  • All nucleic 89
    cDNA 88
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1196354, MGI:2138838
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:213420 Franco-Villanueva A, et al., WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes. Hum Mol Genet. 2014 Aug 15;23(16):4383-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory