Wipf1
Gene Detail

Symbol Name ID

Wipf1 WAS/WASL interacting protein family, member 1 MGI:2178801

Synonyms

D2Ertd120e, Waspip, WIP

Feature Type

protein coding gene

Genetic Map

Chromosome 2

43.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:73429610-73529734 bp, - strand From VEGA annotation of GRCm38   100125 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: WAS/WASL-interacting protein family member
Gene Tree: Wipf1

Human homologs

Human Homolog		WIPF1, WAS/WASL interacting protein family, member 1
NCBI Gene ID		7456
neXtProt AC		NX_O43516
Human Synonyms		PRPL-2, WASPIP, WIP
Human Chr (Location)		2q31.1; chr2:174559574-174682899 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human WIPF1

Mutations, alleles, and phenotypes

All mutations/alleles(20) : Gene trapped(13) Targeted(7)
Genomic Mutations involving Wipf1 (4)
Incidental mutations (data from APF )
 

Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.

 

Interactions

Wipf1 interacts with 351 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	actin cytoskeleton organization, actin filament-based movement, ...
Component	actin cytoskeleton, actin filament, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)

cDNA source data(88)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(89) cDNA(88) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000013425 (Evidence)
Ensembl Gene Model	ENSMUSG00000075284 (Evidence)
Entrez Gene	215280 (Evidence)
UniGene	223504
DFCI	TC1575670, TC1610800, TC1678432
DoTS	DT.101250778, DT.101355936, DT.101403095, DT.535332, DT.94200737
NIA Mouse Gene Index	U022746
Consensus CDS Project	CCDS16131.1
International Mouse Knockout Project Status	Wipf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013425	VEGA Gene Model | MGI Sequence Detail	100125	C57BL/6J
transcript	OTTMUST00000032436	VEGA | MGI Sequence Detail	4728	Not Applicable
polypeptide	OTTMUSP00000014408	VEGA | MGI Sequence Detail	493	Not Applicable

All sequences(69) RefSeq(12) UniProt(4)

Polymorphisms

SNPs within 2kb(678 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003124	WH2 domain
Protein Ontology	PR:000017422	WAS/WASL-interacting protein family member 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199715 Donnelly SK, et al., WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization. Curr Biol. 2013 Jun 3;23(11):999-1006
All references(53)

Other accession IDs

MGI:1196354, MGI:2138838