Wipf1 MGI Mouse Gene Detail - MGI:2178801 - WAS/WASL interacting protein family, member 1

Symbol

Wipf1
Name

WAS/WASL interacting protein family, member 1
Synonyms

D2Ertd120e, Waspip, WIP

Feature Type

protein coding gene
IDs

MGI:2178801
NCBI Gene: 215280
Gene Overview

MyGene.info: WIPF1
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr2:73429610-73529487 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 43.68 cM
Mapping Data

3 experiments

SNPs within 2kb

678 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2178801	protein coding gene	Chr2:73429610-73529734 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025838	protein coding gene	Chr2:73704430-73808643 (-)
A/J	MGP_AJ_G0025816	protein coding gene	Chr2:70809295-70915322 (-)
AKR/J	MGP_AKRJ_G0025784	protein coding gene	Chr2:72755793-72859604 (-)
BALB/cJ	MGP_BALBcJ_G0025810	protein coding gene	Chr2:71001101-71102207 (-)
C3H/HeJ	MGP_C3HHeJ_G0025570	protein coding gene	Chr2:72939932-73042746 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026257	protein coding gene	Chr2:75899167-76001480 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023660	protein coding gene	Chr2:68011867-68110233 (-)
CAST/EiJ	MGP_CASTEiJ_G0025034	protein coding gene	Chr2:73208940-73316501 (-)
CBA/J	MGP_CBAJ_G0025551	protein coding gene	Chr2:78660674-78776202 (-)
DBA/2J	MGP_DBA2J_G0025682	protein coding gene	Chr2:70409971-70510077 (-)
FVB/NJ	MGP_FVBNJ_G0025644	protein coding gene	Chr2:69822551-69923878 (-)
LP/J	MGP_LPJ_G0025770	protein coding gene	Chr2:73582090-73684286 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025675	protein coding gene	Chr2:80598525-80699672 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026314	protein coding gene	Chr2:72839030-72944920 (-)
PWK/PhJ	MGP_PWKPhJ_G0024775	protein coding gene	Chr2:70330469-70435489 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024583	protein coding gene	Chr2:73073688-73179231 (-)
WSB/EiJ	MGP_WSBEiJ_G0025102	protein coding gene	Chr2:73289842-73396237 (-)

Human Ortholog

WIPF1, WAS/WASL interacting protein family member 1

Vertebrate Orthologs

8

Human Ortholog

WIPF1, WAS/WASL interacting protein family member 1
Orthology source: HomoloGene, HGNC
Synonyms

PRPL-2, WAS2, WASPIP, WIP
Links

HGNC:12736

NCBI Gene ID: 7456

neXtProt AC: NX_O43516

UniProt: O43516
Chr Location

2q31.1; chr2:174559574-174682899 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 86891
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: WIPF1
Protein SuperFamily

WAS/WASL-interacting protein family member
Gene Tree

Wipf1

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Phenotype Summary

39 phenotypes from 1 allele in 2 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

1
Gene trapped

13
Targeted

10
Genomic Mutations

7 involving Wipf1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.

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All GO Annotations

17
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

89
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wipf1

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Wipf1 interacts with 350 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

65
RefSeq

12
UniProt

4
CCDS

CCDS16131.1
UniGene

223504

Ensembl

ENSMUSG00000075284 (Evidence)
NCBI Gene

215280

			Length	Strain/Species	Flank
genomic	215280	NCBI Gene Model \| MGI Sequence Detail	99878	C57BL/6J	± kb
transcript	NM_001289722	RefSeq \| MGI Sequence Detail	4486	C57BL/6
polypeptide	Q8K1I7	UniProt \| EBI \| MGI Sequence Detail	493	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017422 WAS/WASL-interacting protein family member 1

(term hierarchy)
InterPro Domains

IPR011993 PH-like domain superfamily

IPR003124 WH2 domain

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All nucleic 90

cDNA 89

Primer pair 1

Microarray probesets 4

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MGI:1196354, MGI:2138838

Summaries

All 70

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 32
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:270863 Keppler SJ, et al., The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses. Cell Rep. 2018 Jul 17;24(3):619-629

TSS for Wipf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24571	Chr2:73529725-73529736 (-)	-244 bp
Tssr24570	Chr2:73529708-73529721 (-)	-228 bp
Tssr24569	Chr2:73529545-73529569 (-)	-70 bp
Tssr24568	Chr2:73529391-73529493 (-)	45 bp
Tssr24567	Chr2:73486465-73486477 (-)	43,016 bp
Tssr24566	Chr2:73486456-73486461 (-)	43,028 bp
Tssr24565	Chr2:73486435-73486451 (-)	43,044 bp
Tssr24564	Chr2:73486405-73486418 (-)	43,075 bp
Tssr24563	Chr2:73485733-73485769 (-)	43,736 bp
Tssr24562	Chr2:73485712-73485730 (-)	43,766 bp
Tssr24561	Chr2:73485682-73485704 (-)	43,794 bp
Tssr24556	Chr2:73453918-73453933 (-)	75,561 bp
Tssr24555	Chr2:73453888-73453900 (-)	75,593 bp
Tssr24554	Chr2:73453869-73453884 (-)	75,610 bp
Tssr24553	Chr2:73452666-73452712 (-)	76,798 bp
Tssr24551	Chr2:73437592-73437607 (-)	91,887 bp
Tssr24550	Chr2:73437523-73437541 (-)	91,955 bp
Tssr24549	Chr2:73437310-73437331 (-)	92,166 bp
Tssr24548	Chr2:73437214-73437236 (-)	92,262 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16