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Wipf1
Gene Detail
Symbol

Name
ID
Wipf1
WAS/WASL interacting protein family, member 1
MGI:2178801
Synonyms
D2Ertd120e, Waspip, WIP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
43.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:73429610-73529734 bp, - strand
From VEGA annotation of GRCm38

  100125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: WIPF1
Protein SuperFamily: WAS/WASL-interacting protein family member
Gene Tree: Wipf1

Human
homologs
WIPF1, WAS/WASL interacting protein family, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7456
neXtProt AC: NX_O43516

Human Synonyms: PRPL-2, WAS2, WASPIP, WIP

Human Chr (Location): 2q31.1; chr2:174559574-174682899 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human WIPF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(13) Targeted(8)
Genomic Mutations involving Wipf1 (5)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutants have immunological abnormalities, although lymphocyte development appears normal. Mutants show abnormal B and T cell proliferative responses, high serum immunoglobulin levels and impaired immunological synapse formation.
 
Phenotype Images(1)
Interactions
Wipf1 interacts with 350 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process actin cytoskeleton organization, actin filament-based movement, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(88)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wipf1    NEW 
Molecular
reagents
All nucleic(89) cDNA(88) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000013425 (Evidence)
Ensembl Gene Model ENSMUSG00000075284 (Evidence)
Entrez Gene 215280 (Evidence)
UniGene 223504
DFCI TC1575670, TC1610800, TC1678432
DoTS DT.101250778, DT.101355936, DT.101403095, DT.535332, DT.94200737
NIA Mouse Gene Index U022746
Consensus CDS Project CCDS16131.1
International Mouse Phenotyping Consortium Status Wipf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013425 VEGA Gene Model | MGI Sequence Detail 100125 C57BL/6J ±  kb
transcript OTTMUST00000032436 VEGA | MGI Sequence Detail 4728 Not Applicable 
polypeptide OTTMUSP00000014408 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(678 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017422 WAS/WASL-interacting protein family member 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:213420 Franco-Villanueva A, et al., WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes. Hum Mol Genet. 2014 Aug 15;23(16):4383-95
All references(52)
Other
accession IDs
MGI:1196354, MGI:2138838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory