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Stab2 Gene Detail
Summary
  • Symbol
    Stab2
  • Name
    stabilin 2
  • Synonyms
    FEEL-2, STAB-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178743
    NCBI Gene: 192188
  • Gene Overview
    MyGene.info: STAB2
Location & Maps
more
  • Sequence Map
    Chr10:86841198-87008025 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      166828 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 43.14 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    STAB2, stabilin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAB2, stabilin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1
  • Links
    NCBI Gene ID: 55576
    neXtProt AC: NX_Q8WWQ8

  • Chr Location
    12q23.3; chr12:103587255-103766729 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23022
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STAB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Stab2
  • Incidental Mutations
Mice homozygous for knock-out alleles exhibit no gross abnormaities. Mice homozygous for one null allele display elevated serum hyaluronic acid levels and decreased metastasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032950 VEGA Gene Model | MGI Sequence Detail 166828 C57BL/6J ±  kb
transcript OTTMUST00000082160 VEGA | MGI Sequence Detail 8228 Not Applicable  
polypeptide OTTMUSP00000044029 VEGA | MGI Sequence Detail 2559 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1417 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:75013 Politz O, et al., Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J. 2002 Feb 15;362(Pt 1):155-64
  • Latest
    J:235394 Woodworth MB, et al., Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep. 2016 May 3;15(5):999-1012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory