About   Help   FAQ
Stab2
Gene Detail
Symbol

Name
ID
Stab2
stabilin 2
MGI:2178743
Synonyms
FEEL-2, STAB-2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
43.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:86841198-87008025 bp, - strand
From VEGA annotation of GRCm38

  166828 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STAB2
Gene Tree: Stab2

Human
homologs
STAB2, stabilin 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55576
neXtProt AC: NX_Q8WWQ8

Human Synonyms: FEEL2, FELE-2, FELL2, FEX2, HARE

Human Chr (Location): 12q23.3; chr12:103587255-103766729 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for knock-out alleles exhibit no gross abnormaities. Mice homozygous for one null allele display elevated serum hyaluronic acid levels and decreased metastasis.
 
Interactions
Stab2 interacts with 155 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, defense response to bacterium, ...
Component cytoplasm, external side of plasma membrane, ...
Function hyaluronic acid binding, low-density lipoprotein particle binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (69)    Tissues (42)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 44
Northern blot 6
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stab2    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000032950 (Evidence)
Ensembl Gene Model ENSMUSG00000035459 (Evidence)
Entrez Gene 192188 (Evidence)
UniGene 279611
DFCI TC1586292
DoTS DT.110618381, DT.484514, DT.91368947
Consensus CDS Project CCDS36021.1
International Mouse Phenotyping Consortium Status Stab2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032950 VEGA Gene Model | MGI Sequence Detail 166828 C57BL/6J ±  kb
transcript OTTMUST00000082160 VEGA | MGI Sequence Detail 8228 Not Applicable 
polypeptide OTTMUSP00000044029 VEGA | MGI Sequence Detail 2559 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(12)
Polymorphisms
SNPs within 2kb(1433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR024731 EGF domain, merozoite surface protein 1-like
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000782 FAS1 domain
InterPro IPR023413 Green fluorescent protein-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000538 Link
Protein Ontology PR:000015702 stabilin-2
References
(Earliest) J:75013 Politz O, et al., Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J. 2002 Feb 15;362(Pt 1):155-64
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory