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Stab2
Gene Detail
Symbol

Name
ID
Stab2
stabilin 2
MGI:2178743
Synonyms
FEEL-2, STAB-2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
43.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:86841198-87008025 bp, - strand
From VEGA annotation of GRCm38

  166828 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Stab2

Human
homologs
Human Homolog STAB2, stabilin 2
NCBI Gene ID 55576
neXtProt AC  NX_Q8WWQ8
Human Synonyms  FEEL2, FELE-2, FELL2, FEX2, HARE
Human Chr (Location)  12q23.3; chr12:103587289-103766729 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for knock-out alleles exhibit no gross abnormaities. Mice homozygous for one null allele display elevated serum hyaluronic acid levels and decreased metastasis.
 
Interactions
Stab2 interacts with 156 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, defense response to bacterium, ...
Component cytoplasm, external side of plasma membrane, ...
Function hyaluronic acid binding, low-density lipoprotein particle binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (54)    Tissues (28)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 35
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032950 (Evidence)
Ensembl Gene ModelENSMUSG00000035459 (Evidence)
Entrez Gene192188 (Evidence)
UniGene279611
DFCITC1586292
DoTSDT.91368947, DT.484514, DT.110618381
Consensus CDS ProjectCCDS36021.1
International Mouse Knockout Project StatusStab2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032950 VEGA Gene Model | MGI Sequence Detail 166828 C57BL/6J ±  kb
transcript OTTMUST00000082160 VEGA | MGI Sequence Detail 8228 Not Applicable 
polypeptide OTTMUSP00000044029 VEGA | MGI Sequence Detail 2559 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(23)
Polymorphisms
SNPs within 2kb(1433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR024731 EGF domain, merozoite surface protein 1-like
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000782 FAS1 domain
InterPro IPR023413 Green fluorescent protein-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000538 Link
Protein Ontology PR:000015702 stabilin-2
References
(Earliest) J:75013 Politz O, et al., Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues. Biochem J. 2002 Feb 15;362(Pt 1):155-64
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory