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Nt5c2 Gene Detail
Summary
  • Symbol
    Nt5c2
  • Name
    5'-nucleotidase, cytosolic II
  • Synonyms
    cN-II, NT5B, PNT5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178563
    NCBI Gene: 76952
Location & Maps
more
  • Sequence Map
    Chr19:46887828-47015153 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      127326 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NT5C2, 5'-nucleotidase, cytosolic II
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NT5C2, 5'-nucleotidase, cytosolic II
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cN-II, GMP, NT5B, PNT5, SPG45, SPG65
  • Links
    NCBI Gene ID: 22978
    neXtProt AC: NX_P49902

  • Chr Location
    10q24.32; chr10:103088017-103193306 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NT5C2 associations

Human Disease Mouse Models
       Spastic Paraplegia 45, Autosomal Recessive; SPG45   OMIM: 613162
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037178 VEGA Gene Model | MGI Sequence Detail 127326 C57BL/6J ±  kb
transcript OTTMUST00000095787 VEGA | MGI Sequence Detail 3148 Not Applicable  
polypeptide OTTMUSP00000053468 VEGA | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    796 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011454 cytosolic purine 5'-nucleotidase
  • EC
  • InterPro Domains
    IPR023214 HAD-like domain
    IPR008380 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase
    IPR016695 Purine 5'-nucleotidase
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1924202
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory