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Akap9 Gene Detail
Summary
  • Symbol
    Akap9
  • Name
    A kinase (PRKA) anchor protein (yotiao) 9
  • Synonyms
    5730481H23Rik, AKAP450, G1-448-15, mei2-5, mKIAA0803, repro12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178217
    NCBI Gene: 100986
  • Gene Overview
    MyGene.info: AKAP9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:3928054-4081310 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      153257 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 2.26 cM, cytoband A2
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    AKAP9, A-kinase anchoring protein 9
  • Vertebrate Orthologs
    2
  • Human Ortholog
    AKAP9, A-kinase anchoring protein 9
    Orthology source: HGNC
  • Synonyms
    AKAP350, AKAP450, AKAP-9, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO
  • Links
    NCBI Gene ID: 10142
    neXtProt AC: NX_Q99996
    UniProt: Q99996

  • Chr Location
    7q21.2; chr7:91940867-92110673 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AKAP9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 9 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a chemically induced allele exhibit male infertily with abnormal spermatogenesis and Sertoli maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016263 VEGA Gene Model | MGI Sequence Detail 153257 C57BL/6J ±  kb
    transcript OTTMUST00000038992 VEGA | MGI Sequence Detail 13123 Not Applicable  
    polypeptide OTTMUSP00000017425 VEGA | MGI Sequence Detail 3779 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1145 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR028745 A-kinase anchor protein 9/Pericentrin
      IPR019528 Pericentrin/AKAP-450 centrosomal targeting domain
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1913889, MGI:2141218, MGI:2141306, MGI:3050556, MGI:3512794
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:236302 Zhang X, et al., Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory