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Akap9 Gene Detail
Summary
  • Symbol
    Akap9
  • Name
    A kinase (PRKA) anchor protein (yotiao) 9
  • Synonyms
    5730481H23Rik, AKAP450, G1-448-15, mei2-5, mKIAA0803, repro12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178217
    NCBI Gene: 100986
  • Gene Overview
    MyGene.info: AKAP9
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:3927827-4080204 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 2.26 cM, cytoband A2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178217
protein coding gene Chr5:3927827-4081310 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029266
protein coding gene Chr5:757060-906447 (+)
A/J MGP_AJ_G0029230
protein coding gene Chr5:644445-798898 (+)
AKR/J MGP_AKRJ_G0029180
protein coding gene Chr5:647814-802634 (+)
BALB/cJ MGP_BALBcJ_G0029248
protein coding gene Chr5:860925-1007993 (+)
C3H/HeJ MGP_C3HHeJ_G0028968
protein coding gene Chr5:842969-1006374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029697
protein coding gene Chr5:1029448-1190025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026939
protein coding gene Chr5:661980-805883 (+)
CAST/EiJ MGP_CASTEiJ_G0028381
protein coding gene Chr5:847448-1012735 (+)
CBA/J MGP_CBAJ_G0028929
protein coding gene Chr5:952183-1095648 (+)
DBA/2J MGP_DBA2J_G0029081
protein coding gene Chr5:809581-959005 (+)
FVB/NJ MGP_FVBNJ_G0029042
protein coding gene Chr5:701063-844639 (+)
LP/J MGP_LPJ_G0029171
protein coding gene Chr5:820541-979662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029069
protein coding gene Chr5:828106-1000923 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029729
protein coding gene Chr5:770140-923964 (+)
PWK/PhJ MGP_PWKPhJ_G0028100
protein coding gene Chr5:767747-914262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027934
protein coding gene Chr5:1069177-1220569 (+)
WSB/EiJ MGP_WSBEiJ_G0028461
protein coding gene Chr5:790933-940176 (+)



Homology
more
  • Human Ortholog
    AKAP9, A-kinase anchoring protein 9
  • Vertebrate Orthologs
    2
  • Human Ortholog
    AKAP9, A-kinase anchoring protein 9
    Orthology source: HGNC
  • Synonyms
    AKAP350, AKAP450, AKAP-9, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO
  • Links
    NCBI Gene ID: 10142
    neXtProt AC: NX_Q99996
    UniProt: Q99996

  • Chr Location
    7q21.2; chr7:91940867-92110673 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AKAP9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 9 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a chemically induced allele exhibit male infertily with abnormal spermatogenesis and Sertoli maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100986 NCBI Gene Model | MGI Sequence Detail 152378 C57BL/6J ±  kb
    transcript NM_194462 RefSeq | MGI Sequence Detail 12105 Not Specified  
    polypeptide Q70FJ1 UniProt | EBI | MGI Sequence Detail 3797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR028745 A-kinase anchor protein 9/Pericentrin
      IPR019528 Pericentrin/AKAP-450 centrosomal targeting domain
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1913889, MGI:2141218, MGI:2141306, MGI:3050556, MGI:3512794
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:236302 Zhang X, et al., Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory