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Arhgdia
Gene Detail
 Symbol
Name
ID
Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
MGI:2178103
Synonyms 5330430M07Rik, Rho-GDI, Rho GDIalpha
Feature Type protein coding gene
Genetic Map
Chromosome 11
84.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:120578104-120581624 bp, - strand
From VEGA annotation of GRCm38

  3521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: rho GDP dissociation inhibitor
Gene Tree: Arhgdia

Human
homologs
Human Homolog ARHGDIA, Rho GDP dissociation inhibitor (GDI) alpha
NCBI Gene ID 396
neXtProt AC  NX_P52565
Human Synonyms  GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
Human Chr (Location)  17q25.3; chr17:81867721-81871406 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARHGDIA
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null mutation develop nephrotic syndrome, including renal tubule dilation and degeneration, leading to premature death from renal failure. Male mice are sterile and female mice exhibit reduced fertility from postimplantation defects.
 
Human Diseases Modeled Using Mouse Arhgdia (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Arhgdia interacts with 162 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of cell migration, regulation of catalytic activity, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (4)    Images (3)
Theiler Stages: 15, 19, 20, 28
Assay TypeResults
Western blot 5
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004092 (Evidence)
Ensembl Gene ModelENSMUSG00000025132 (Evidence)
Entrez Gene192662 (Evidence)
DFCITC1573187
DoTSDT.101224648, DT.110517951, DT.537094, DT.55201905, DT.94300412, DT.97360942
PDB4F38
Consensus CDS ProjectCCDS25743.1
International Mouse Knockout Project StatusArhgdia
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004092 VEGA Gene Model | MGI Sequence Detail 3521 C57BL/6J ±  kb
transcript OTTMUST00000009205 VEGA | MGI Sequence Detail 1867 Not Applicable 
polypeptide OTTMUSP00000004486 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR024792 Rho GDP-dissociation inhibitor domain
InterPro IPR000406 RHO protein GDP dissociation inhibitor
Protein Ontology PR:000004242 rho GDP-dissociation inhibitor 1
References (Earliest) J:36812 Zalcman G, et al., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 29;271(48):30366-74
(Latest) J:176032 Shibata S, et al., Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest. 2011 Aug 1;121(8):3233-43
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:1924426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory