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Arhgdia Gene Detail
Summary
  • Symbol
    Arhgdia
  • Name
    Rho GDP dissociation inhibitor (GDI) alpha
  • Synonyms
    5330430M07Rik, Rho-GDI, Rho GDIalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178103
    NCBI Gene: 192662
  • Gene Overview
    MyGene.info: ARHGDIA
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120578104-120581624 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178103
protein coding gene Chr11:120577235-120581624 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019511
protein coding gene Chr11:125049410-125052930 (-)
A/J MGP_AJ_G0019479
protein coding gene Chr11:119487078-119490598 (-)
AKR/J MGP_AKRJ_G0019449
protein coding gene Chr11:123082291-123085811 (-)
BALB/cJ MGP_BALBcJ_G0019454
protein coding gene Chr11:119842839-119846359 (-)
C3H/HeJ MGP_C3HHeJ_G0019260
protein coding gene Chr11:123418200-123421784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019902
protein coding gene Chr11:128838270-128841790 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017528
protein coding gene Chr11:116478675-116482211 (-)
CAST/EiJ MGP_CASTEiJ_G0018814
protein coding gene Chr11:124917228-124921467 (-)
CBA/J MGP_CBAJ_G0019231
protein coding gene Chr11:133874532-133878052 (-)
DBA/2J MGP_DBA2J_G0019343
protein coding gene Chr11:118856205-118859725 (-)
FVB/NJ MGP_FVBNJ_G0019335
protein coding gene Chr11:118568076-118572064 (-)
LP/J MGP_LPJ_G0019415
protein coding gene Chr11:125353738-125357126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019368
protein coding gene Chr11:132711044-132714577 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019942
protein coding gene Chr11:123770815-123774335 (-)
PWK/PhJ MGP_PWKPhJ_G0018580
protein coding gene Chr11:120292075-120296497 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018372
protein coding gene Chr11:123533832-123537353 (-)
WSB/EiJ MGP_WSBEiJ_G0018866
protein coding gene Chr11:123760219-123763739 (-)



Homology
more
  • Human Ortholog
    ARHGDIA, Rho GDP dissociation inhibitor alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGDIA, Rho GDP dissociation inhibitor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
  • Links
    NCBI Gene ID: 396
    neXtProt AC: NX_P52565
    UniProt: P52565

  • Chr Location
    17q25.3; chr17:81867719-81871406 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Arhgdia mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation develop nephrotic syndrome, including renal tubule dilation and degeneration, leading to premature death from renal failure. Male mice are sterile and female mice exhibit reduced fertility from postimplantation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025132 Ensembl Gene Model | MGI Sequence Detail 3521 C57BL/6J ±  kb
    transcript ENSMUST00000106197 Ensembl | MGI Sequence Detail 1867 Not Applicable  
    polypeptide ENSMUSP00000101803 Ensembl | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924426
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 13
      Phenotypes 12
    • Earliest
      J:36812 Zalcman G, et al., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 29;271(48):30366-74
    • Latest
      J:224425 Lee HS, et al., Protein tyrosine phosphatase-PEST and beta8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol. 2015 Apr;35(8):1401-13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory