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Arhgdia
Gene Detail
Symbol

Name
ID
Arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
MGI:2178103
Synonyms
5330430M07Rik, Rho-GDI, Rho GDIalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:120578104-120581624 bp, - strand
From VEGA annotation of GRCm38

  3521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGDIA
Protein SuperFamily: rho GDP dissociation inhibitor
Gene Tree: Arhgdia

Human
homologs
ARHGDIA, Rho GDP dissociation inhibitor (GDI) alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 396
neXtProt AC: NX_P52565

Human Synonyms: GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1

Human Chr (Location): 17q25.3; chr17:81867719-81871406 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARHGDIA

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null mutation develop nephrotic syndrome, including renal tubule dilation and degeneration, leading to premature death from renal failure. Male mice are sterile and female mice exhibit reduced fertility from postimplantation defects.
 
Human Diseases Modeled in Mice Using Arhgdia (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Arhgdia interacts with 162 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular response to mechanical stimulus, negative regulation of cell migration, ...
Component cytoplasm, cytosol, ...
Function fatty acid binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (4)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 5
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ARHGDIA ; Xenbase arhgdia ; ZFIN arhgdia    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000004092 (Evidence)
Ensembl Gene Model ENSMUSG00000025132 (Evidence)
Entrez Gene 192662 (Evidence)
DFCI TC1573187
DoTS DT.101224648, DT.110517951, DT.537094, DT.55201905, DT.94300412, DT.97360942
PDB 4F38
Consensus CDS Project CCDS25743.1
International Mouse Phenotyping Consortium Status Arhgdia
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004092 VEGA Gene Model | MGI Sequence Detail 3521 C57BL/6J ±  kb
transcript OTTMUST00000009205 VEGA | MGI Sequence Detail 1867 Not Applicable 
polypeptide OTTMUSP00000004486 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR024792 Rho GDP-dissociation inhibitor domain
InterPro IPR000406 Rho protein GDP-dissociation inhibitor
Protein Ontology PR:000004242 rho GDP-dissociation inhibitor 1
References
(Earliest) J:36812 Zalcman G, et al., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 29;271(48):30366-74
(Latest) J:219617 Williamson RC, et al., Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. J Cell Sci. 2014 Oct 1;127(Pt 19):4292-307
All references(50)
Disease annotation references (1)
Other
accession IDs
MGI:1924426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory