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Pla2g15
Gene Detail
Symbol

Name
ID
Pla2g15
phospholipase A2, group XV
MGI:2178076
Synonyms
C87498, LLPL, Lpla2, Lypla3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:106150399-106164713 bp, + strand
From Ensembl annotation of GRCm38

  14315 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLA2G15
Protein SuperFamily: phosphatidylcholine-sterol acyltransferase
Gene Tree: Pla2g15

Human
homologs
PLA2G15, phospholipase A2, group XV
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23659
neXtProt AC: NX_Q8NCC3

Human Synonyms: ACS, GXVPLA2, LLPL, LPLA2, LYPLA3

Human Chr (Location): 16q22.1; chr16:68245343-68261062 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice do not develop atherosclerotic lesions even when fed an atherogenic diet.
 
Interactions
Pla2g15 interacts with 172 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (104)    Tissues (103)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 10
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PLA2G15 ; Xenbase pla2g15    NEW 
Molecular
reagents
All nucleic(76) cDNA(75) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031903 (Evidence)
Entrez Gene 192654 (Evidence)
UniGene 284770
DFCI TC1572514, TC1612426
DoTS DT.101388509, DT.531660
NIA Mouse Gene Index U009768
EC 2.3.1.-
Consensus CDS Project CCDS22630.1
International Mouse Phenotyping Consortium Status Pla2g15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031903 Ensembl Gene Model | MGI Sequence Detail 14315 C57BL/6J ±  kb
transcript ENSMUST00000034377 Ensembl | MGI Sequence Detail 2704 Not Applicable 
polypeptide ENSMUSP00000034377 Ensembl | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029058 Alpha/Beta hydrolase fold
InterPro IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
Protein Ontology PR:000010007 group XV phospholipase A2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:162943 Abe A, et al., The measurement of lysosomal phospholipase A2 activity in plasma. J Lipid Res. 2010 Aug;51(8):2464-70
All references(41)
Other
accession IDs
MGI:2142884

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory