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Tmem259 Gene Detail
Summary
  • Symbol
    Tmem259
  • Name
    transmembrane protein 259
  • Synonyms
    membralin, ORF61
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177957
    NCBI Gene: 216157
Location & Maps
more
  • Sequence Map
    Chr10:79974948-79984330 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9383 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TMEM259, transmembrane protein 259
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEM259, transmembrane protein 259
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASBABP1, C19orf6, MBRL, MEMBRALIN, R32184_3
  • Links
    NCBI Gene ID: 91304
    neXtProt AC: NX_Q4ZIN3

  • Chr Location
    19p13.3; chr19:1009651-1021169 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Tmem259
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019134 VEGA Gene Model | MGI Sequence Detail 9383 C57BL/6J ±  kb
transcript OTTMUST00000045865 VEGA | MGI Sequence Detail 2225 Not Applicable  
polypeptide OTTMUSP00000020663 VEGA | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 102
    Genomic 1
    cDNA 100
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2158302
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:80938 Andersson O, et al., Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system. Brain Res Gene Expr Patterns. 2002 Oct;1(3-4):205-12
  • Latest
    J:223306 Yang B, et al., The critical role of membralin in postnatal motor neuron survival and disease. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory