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Tmem259 Gene Detail
Summary
  • Symbol
    Tmem259
  • Name
    transmembrane protein 259
  • Synonyms
    membralin, ORF61
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177957
    NCBI Gene: 216157
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79977120-79984330 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177957
protein coding gene Chr10:79974948-79984330 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017475
protein coding gene Chr10:80546313-80557377 (-)
A/J MGP_AJ_G0017453
protein coding gene Chr10:77731135-77740479 (-)
AKR/J MGP_AKRJ_G0017414
protein coding gene Chr10:79848638-79857984 (-)
BALB/cJ MGP_BALBcJ_G0017415
protein coding gene Chr10:77958228-77967847 (-)
C3H/HeJ MGP_C3HHeJ_G0017238
protein coding gene Chr10:79954722-79964091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017869
protein coding gene Chr10:83328192-83341582 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015557
protein coding gene Chr10:73956731-73966350 (-)
CAST/EiJ MGP_CASTEiJ_G0016805
protein coding gene Chr10:80150760-80161149 (-)
CBA/J MGP_CBAJ_G0017210
protein coding gene Chr10:86555708-86568154 (-)
DBA/2J MGP_DBA2J_G0017316
protein coding gene Chr10:76947567-76957342 (-)
FVB/NJ MGP_FVBNJ_G0017310
protein coding gene Chr10:76126957-76136342 (-)
LP/J MGP_LPJ_G0017387
protein coding gene Chr10:81023273-81032437 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017336
protein coding gene Chr10:88519035-88528399 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017910
protein coding gene Chr10:79838068-79847442 (-)
PWK/PhJ MGP_PWKPhJ_G0016586
protein coding gene Chr10:76813707-76823529 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016375
protein coding gene Chr10:78808811-78819255 (-)
WSB/EiJ MGP_WSBEiJ_G0016865
protein coding gene Chr10:79860749-79872880 (-)



Homology
more
  • Human Ortholog
    TMEM259, transmembrane protein 259
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEM259, transmembrane protein 259
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASBABP1, C19orf6, MBRL, MEMBRALIN, R32184_3
  • Links
    NCBI Gene ID: 91304
    neXtProt AC: NX_Q4ZIN3
    UniProt: Q4ZIN3

  • Chr Location
    19p13.3; chr19:1009651-1021169 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    2 involving Tmem259
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 216157 NCBI Gene Model | MGI Sequence Detail 7211 C57BL/6J ±  kb
transcript NM_001359632 RefSeq | MGI Sequence Detail 2242 C57BL/6  
polypeptide Q8CIV2 UniProt | EBI | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    Genomic 1
    cDNA 100

    Microarray probesets 4
Other
Accession IDs
less
MGI:2158302
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:257251 Zhu B, et al., ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating gamma-secretase activity. Nat Commun. 2017 Nov 13;8(1):1472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory