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Bco2 Gene Detail
Summary
  • Symbol
    Bco2
  • Name
    beta-carotene oxygenase 2
  • Synonyms
    Bcdo2, Bcmo2, B-diox-II, beta-diox-II, CMO2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177469
    NCBI Gene: 170752
Location & Maps
more
  • Sequence Map
    Chr9:50533087-50555181 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22095 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.74 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    BCO2, beta-carotene oxygenase 2
  • Vertebrate Orthologs
    13
  • Human Ortholog
    BCO2, beta-carotene oxygenase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCDO2, B-DIOX-II
  • Links
    NCBI Gene ID: 83875
    neXtProt AC: NX_Q9BYV7

  • Chr Location
    11q23.1; chr11:112175485-112218929 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased spleen weight, decreased testis and seminal vesicle weight, and increased tissue lycopene and beta-carotene levels when fed diets containing tomato powder or lycopene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030004 VEGA Gene Model | MGI Sequence Detail 22095 C57BL/6J ±  kb
transcript OTTMUST00000074410 VEGA | MGI Sequence Detail 2118 Not Applicable  
polypeptide OTTMUSP00000038726 VEGA | MGI Sequence Detail 532 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    154 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:74948 Kiefer C, et al., Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001 Apr 27;276(17):14110-6
  • Latest
    J:236153 Costabile BK, et al., beta-Apo-10'-carotenoids Modulate Placental Microsomal Triglyceride Transfer Protein Expression and Function to Optimize Transport of Intact beta-Carotene to the Embryo. J Biol Chem. 2016 Aug 26;291(35):18525-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory