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Bco2 Gene Detail
Summary
  • Symbol
    Bco2
  • Name
    beta-carotene oxygenase 2
  • Synonyms
    Bcdo2, Bcmo2, B-diox-II, beta-diox-II, CMO2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177469
    NCBI Gene: 170752
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50533087-50555181 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.74 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177469
protein coding gene Chr9:50533087-50555221 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034778
protein coding gene Chr9:49423457-49446695 (-)
A/J MGP_AJ_G0034759
protein coding gene Chr9:47914211-47937881 (-)
AKR/J MGP_AKRJ_G0034687
protein coding gene Chr9:48927351-48948787 (-)
BALB/cJ MGP_BALBcJ_G0034751
protein coding gene Chr9:47643049-47663988 (-)
C3H/HeJ MGP_C3HHeJ_G0034461
protein coding gene Chr9:49410371-49431850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035271
protein coding gene Chr9:50803891-50825065 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032184
protein coding gene Chr9:47385478-47405986 (-)
CAST/EiJ MGP_CASTEiJ_G0033783
protein coding gene Chr9:49358595-49381335 (-)
CBA/J MGP_CBAJ_G0034433
protein coding gene Chr9:52611395-52631149 (-)
DBA/2J MGP_DBA2J_G0034592
protein coding gene Chr9:47778790-47800751 (-)
FVB/NJ MGP_FVBNJ_G0034533
protein coding gene Chr9:46998022-47017841 (-)
LP/J MGP_LPJ_G0034673
protein coding gene Chr9:49784908-49804713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034577
protein coding gene Chr9:54213946-54237146 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035292
protein coding gene Chr9:48904844-48926705 (-)
PWK/PhJ MGP_PWKPhJ_G0033488
protein coding gene Chr9:47755976-47778328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033323
protein coding gene Chr9:49216167-49239329 (-)
WSB/EiJ MGP_WSBEiJ_G0033896
protein coding gene Chr9:48906558-48926902 (-)



Homology
more
  • Human Ortholog
    BCO2, beta-carotene oxygenase 2
  • Vertebrate Orthologs
    13
  • Human Ortholog
    BCO2, beta-carotene oxygenase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCDO2, B-DIOX-II
  • Links
    NCBI Gene ID: 83875
    neXtProt AC: NX_Q9BYV7
    UniProt: Q9BYV7

  • Chr Location
    11q23.1; chr11:112175485-112218929 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased spleen weight, decreased testis and seminal vesicle weight, and increased tissue lycopene and beta-carotene levels when fed diets containing tomato powder or lycopene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032066 Ensembl Gene Model | MGI Sequence Detail 22095 C57BL/6J ±  kb
    transcript ENSMUST00000119103 Ensembl | MGI Sequence Detail 2118 Not Applicable  
    polypeptide ENSMUSP00000112727 Ensembl | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:74948 Kiefer C, et al., Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001 Apr 27;276(17):14110-6
    • Latest
      J:265585 Lim JY, et al., Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. Arch Biochem Biophys. 2018 Sep 15;654:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory