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Bco2
Gene Detail
 Symbol
Name
ID
Bco2
beta-carotene oxygenase 2
MGI:2177469
Synonyms Bcdo2, Bcmo2, B-diox-II, beta-diox-II, CMO2
Feature Type protein coding gene
Genetic Map
Chromosome 9
27.74 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:50533087-50555181 bp, - strand
From VEGA annotation of GRCm38

  22095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 3 zebrafish

Protein SuperFamily: carotenoid oxygenase
Gene Tree: Bco2

Human
homologs
Human Homolog BCO2, beta-carotene oxygenase 2
NCBI Gene ID 83875
neXtProt AC  NX_Q9BYV7
Human Synonyms  BCDO2, B-DIOX-II
Human Chr (Location)  11q23.1; chr11:112175485-112218929 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased spleen weight, decreased testis and seminal vesicle weight, and increased tissue lycopene and beta-carotene levels when fed diets containing tomato powder or lycopene.
 
Interactions
Bco2 interacts with 68 markers (Mir30c-1, Mir30c-2, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process carotene catabolic process, carotene metabolic process, ...
Component intracellular, mitochondrion
Function dioxygenase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (12)   
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 28
Assay TypeResults
RT-PCR 16
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030004 (Evidence)
Ensembl Gene ModelENSMUSG00000032066 (Evidence)
Entrez Gene170752 (Evidence)
UniGene390149
DFCITC1641178
DoTSDT.483405
NIA Mouse Gene IndexU030840
EC1.13.11.71
Consensus CDS ProjectCCDS40620.1
International Mouse Knockout Project StatusBco2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030004 VEGA Gene Model | MGI Sequence Detail 22095 C57BL/6J ±  kb
transcript OTTMUST00000074410 VEGA | MGI Sequence Detail 2118 Not Applicable 
polypeptide OTTMUSP00000038726 VEGA | MGI Sequence Detail 532 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004294 Carotenoid oxygenase
Protein Ontology PR:000004708 beta,beta-carotene 9',10'-oxygenase
References (Earliest) J:74948 Kiefer C, et al., Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J Biol Chem. 2001 Apr 27;276(17):14110-6
(Latest) J:204979 Amengual J, et al., Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J Biol Chem. 2013 Nov 22;288(47):34081-96
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory