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Trhr2 Gene Detail
Summary
  • Symbol
    Trhr2
  • Name
    thyrotropin releasing hormone receptor 2
  • Synonyms
    TRH-R2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177284
    NCBI Gene: 170732
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:122356967-122360746 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.95 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177284
protein coding gene Chr8:122356065-122362907 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034221
protein coding gene Chr8:125887471-125891201 (-)
A/J MGP_AJ_G0034201
protein coding gene Chr8:120679009-120682740 (-)
AKR/J MGP_AKRJ_G0034128
protein coding gene Chr8:124198683-124202414 (-)
BALB/cJ MGP_BALBcJ_G0034195
protein coding gene Chr8:120882134-120885696 (-)
C3H/HeJ MGP_C3HHeJ_G0033906
protein coding gene Chr8:124897813-124901544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034715
protein coding gene Chr8:130077724-130081452 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031657
protein coding gene Chr8:113506825-113510732 (-)
CAST/EiJ MGP_CASTEiJ_G0033233
protein coding gene Chr8:124968460-124974798 (-)
CBA/J MGP_CBAJ_G0033879
protein coding gene Chr8:134883431-134887198 (-)
DBA/2J MGP_DBA2J_G0034035
protein coding gene Chr8:119873153-119876912 (-)
FVB/NJ MGP_FVBNJ_G0033978
protein coding gene Chr8:118996159-119000599 (-)
LP/J MGP_LPJ_G0034124
protein coding gene Chr8:126019724-126023454 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034025
protein coding gene Chr8:137055893-137059623 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034733
protein coding gene Chr8:124380070-124385575 (-)
PWK/PhJ MGP_PWKPhJ_G0032935
protein coding gene Chr8:119688335-119692176 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032775
protein coding gene Chr8:123104575-123108222 (-)
WSB/EiJ MGP_WSBEiJ_G0033349
protein coding gene Chr8:125131746-125135308 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039079 Ensembl Gene Model | MGI Sequence Detail 3780 C57BL/6J ±  kb
transcript ENSMUST00000044123 Ensembl | MGI Sequence Detail 1340 Not Applicable  
polypeptide ENSMUSP00000042575 Ensembl | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR002120 Thyrotropin-releasing hormone receptor
Molecular
Reagents
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  • All nucleic 7
    Genomic 2
    cDNA 4
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Gene Ontology 3
  • Earliest
    J:74954 Harder S, et al., Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2). Endocrinology. 2001 Mar;142(3):1188-94
  • Latest
    J:252758 Muller-Fielitz H, et al., Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017 Sep 07;8(1):484

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory