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Ppp1r3b Gene Detail
Summary
  • Symbol
    Ppp1r3b
  • Name
    protein phosphatase 1, regulatory (inhibitor) subunit 3B
  • Synonyms
    GL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177268
    NCBI Gene: 244416
Location & Maps
more
  • Sequence Map
    Chr8:35375739-35388139 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12401 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 21.16 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PPP1R3B, protein phosphatase 1 regulatory subunit 3B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP1R3B, protein phosphatase 1 regulatory subunit 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GL, PPP1R4, PTG
  • Links
    NCBI Gene ID: 79660
    neXtProt AC: NX_Q86XI6

  • Chr Location
    8p23.1; chr8:9136254-9151642 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a knock-in point mutation exhibit improved glucose tolerance and increased weight loss and serum glucose level in response to a 36 hour fast.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061024 VEGA Gene Model | MGI Sequence Detail 12401 C57BL/6J ±  kb
transcript OTTMUST00000149113 VEGA | MGI Sequence Detail 4349 Not Applicable  
polypeptide OTTMUSP00000077415 VEGA | MGI Sequence Detail 284 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    157 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013125 protein phosphatase 1 regulatory subunit 3B
  • InterPro Domains
    IPR005036 CBM21 (carbohydrate binding type-21) domain
    IPR017434 Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
Molecular
Reagents
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  • All nucleic 36
    cDNA 33
    Primer pair 3

    Microarray probesets 1
Other
Accession IDs
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MGI:2142819
References
more
  • Summaries
    All 25
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:75021 Munro S, et al., Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver. Diabetes. 2002 Mar;51(3):591-8
  • Latest
    J:208923 von Wilamowitz-Moellendorff A, et al., Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes. 2013 Dec;62(12):4070-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory