About   Help   FAQ
Ppp1r3b
Gene Detail
Symbol

Name
ID
Ppp1r3b
protein phosphatase 1, regulatory (inhibitor) subunit 3B
MGI:2177268
Synonyms
GL
Feature Type
protein coding gene
Genetic Map
Chromosome 8
21.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:35375741-35388124 bp, + strand
From Ensembl annotation of GRCm38

  12384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP1R3B
Protein SuperFamily: protein phosphatase 1, glycogen targeting subunit, animal type
Gene Tree: Ppp1r3b

Human
homologs
PPP1R3B, protein phosphatase 1, regulatory subunit 3B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79660
neXtProt AC: NX_Q86XI6

Human Synonyms: GL, PPP1R4, PTG

Human Chr (Location): 8p23.1; chr8:9136254-9151642 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in point mutation exhibit improved glucose tolerance and increased weight loss and serum glucose level in response to a 36 hour fast.
 
Interactions
Ppp1r3b interacts with 321 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process carbohydrate metabolic process, dephosphorylation, ...
Component glycogen granule, intracellular membrane-bounded organelle, ...
Function enzyme binding, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (182)    Tissues (47)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
Northern blot 21
RT-PCR 24
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp1r3b ; ZFIN ppp1r3b    NEW 
Molecular
reagents
All nucleic(36) cDNA(33) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000046794 (Evidence)
Entrez Gene 244416 (Evidence)
UniGene 247126
DFCI TC1600797, TC1604782
DoTS DT.40139739, DT.102556317
NIA Mouse Gene Index U009256
Consensus CDS Project CCDS22243.1
International Mouse Phenotyping Consortium Status Ppp1r3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046794 Ensembl Gene Model | MGI Sequence Detail 12384 C57BL/6J ±  kb
transcript ENSMUST00000070481 Ensembl | MGI Sequence Detail 4206 Not Applicable 
polypeptide ENSMUSP00000065679 Ensembl | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017434 Protein phosphatase 1, glycogen targeting subunit, Metazoa
InterPro IPR005036 Putative phosphatase regulatory subunit
Protein Ontology PR:000013125 protein phosphatase 1 regulatory subunit 3B
References
(Earliest) J:75021 Munro S, et al., Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver. Diabetes. 2002 Mar;51(3):591-8
(Latest) J:208923 von Wilamowitz-Moellendorff A, et al., Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes. 2013 Dec;62(12):4070-82
All references(27)
Other
accession IDs
MGI:2142819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory