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Ppp1r3b
Gene Detail
 Symbol
Name
ID
Ppp1r3b
protein phosphatase 1, regulatory (inhibitor) subunit 3B
MGI:2177268
Synonyms GL
Feature Type protein coding gene
Genetic Map
Chromosome 8
21.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:35375741-35388124 bp, + strand
From Ensembl annotation of GRCm38

  12384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein phosphatase 1, glycogen targeting subunit, animal type
Gene Tree: Ppp1r3b

Human
homologs
Human Homolog PPP1R3B, protein phosphatase 1, regulatory subunit 3B
NCBI Gene ID 79660
neXtProt AC  NX_Q86XI6
Human Synonyms  GL, PPP1R4, PTG
Human Chr (Location)  8p23.1; chr8:9136254-9151642 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in point mutation exhibit improved glucose tolerance and increased weight loss and serum glucose level in response to a 36 hour fast.
 
Interactions
Ppp1r3b interacts with 321 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process carbohydrate metabolic process, dephosphorylation, ...
Component glycogen granule, intracellular membrane-bounded organelle, ...
Function enzyme binding, phosphoprotein phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (182)    Tissues (47)    Images (25)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 137
Northern blot 21
RT-PCR 24
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(33) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000046794 (Evidence)
Entrez Gene244416 (Evidence)
UniGene247126
DFCITC1600797, TC1604782
DoTSDT.102556317, DT.40139739
NIA Mouse Gene IndexU009256
Consensus CDS ProjectCCDS22243.1
International Mouse Knockout Project StatusPpp1r3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046794 Ensembl Gene Model | MGI Sequence Detail 12384 C57BL/6J ±  kb
transcript ENSMUST00000070481 Ensembl | MGI Sequence Detail 4206 Not Applicable 
polypeptide ENSMUSP00000065679 Ensembl | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017434 Protein phosphatase 1, glycogen targeting subunit, Metazoa
InterPro IPR005036 Putative phosphatase regulatory subunit
Protein Ontology PR:000013125 protein phosphatase 1 regulatory subunit 3B
References (Earliest) J:75021 Munro S, et al., Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver. Diabetes. 2002 Mar;51(3):591-8
(Latest) J:208923 von Wilamowitz-Moellendorff A, et al., Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes. 2013 Dec;62(12):4070-82
All references(27)
Other
accession IDs
MGI:2142819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory