Cd99l2 MGI Mouse Gene Detail - MGI:2177151

Symbol

Cd99l2
Name

CD99 antigen-like 2
Synonyms

Mic2l1

Feature Type

protein coding gene
IDs

MGI:2177151
NCBI Gene: 171486
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:70463666-70536455 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 36.82 cM
Mapping Data

2 experiments

SNPs within 2kb

1698 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2177151	protein coding gene	ChrX:70463666-70536467 (-)
129S1/SvImJ	ENSMUSG00200040609	protein coding gene	ChrX:52602873-52675917 (-)
A/J	ENSMUSG00195031740	protein coding gene	ChrX:56230431-56303479 (-)
AKR/J	ENSMUSG00220043790	protein coding gene	ChrX:51515326-51588367 (-)
BALB/cJ	ENSMUSG00180045887	protein coding gene	ChrX:52817352-52890385 (-)
C3H/HeJ	ENSMUSG00175034800	protein coding gene	ChrX:56386236-56459271 (-)
C57BL/6NJ	ENSMUSG00215039733	protein coding gene	ChrX:52857449-52930239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033131	protein coding gene	ChrX:66561419-66643259 (-)
CAST/EiJ	ENSTCUG00005041604	protein coding gene	ChrX:54356449-54429383 (-)
CBA/J	ENSMUSG00210043039	protein coding gene	ChrX:53058488-53131518 (-)
DBA/2J	ENSMUSG00185031298	protein coding gene	ChrX:65501221-65574250 (-)
FVB/NJ	ENSMUSG00205028117	protein coding gene	ChrX:52612578-52685637 (-)
JF1/MsJ	ENSUMUG00000044309	protein coding gene	ChrX:86307476-86379772 (-)
LP/J	ENSMUSG00230030134	protein coding gene	ChrX:72057079-72130098 (-)
NOD/ShiLtJ	ENSMUSG00190028446	protein coding gene	ChrX:52312281-52385314 (-)
NZO/HlLtJ	ENSMUSG00225048494	protein coding gene	ChrX:77261310-77334344 (-)
PWK/PhJ	ENSLUMG00010045650	protein coding gene	ChrX:52181314-52253646 (-)
SPRET/EiJ	ENSMSPG00010030375	protein coding gene	ChrX:55160355-55241684 (-)
WSB/EiJ	ENSIUOG00005046980	protein coding gene	ChrX:53266028-53339091 (-)

Human Ortholog

CD99L2, CD99 molecule like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD99L2, CD99 molecule like 2
Synonyms

CD99B, MIC2L1
Links

HGNC:18237

NCBI Gene ID: 83692

UniProt: Q8TCZ2
Chr Location

Xq28; chrX:150766336-150898816 (-) GRCh38

MGI Vertebrate Homology

Cd99l2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD99L2
Gene Tree

Cd99l2

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Phenotype Summary

2 phenotypes from 2 alleles in 1 genetic background
4 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Find Mice (IMSR)

3 strains or lines available

Homozygous KO in endothelial cells hinders neutrophil and T cell extravasation and reduces the delayed-type (type IV) hypersensitivity reaction in inflamed tissue.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

85
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd99l2

ZFIN cd99l2

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All Sequences

81
RefSeq

16
UniProt

3
CCDS

CCDS30179.1, CCDS57761.1

Ensembl

ENSMUSG00000035776 (Evidence)
NCBI Gene

171486

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035776	Ensembl Gene Model \| MGI Sequence Detail	72790	C57BL/6J	± kb
transcript	ENSMUST00000037391	Ensembl \| MGI Sequence Detail	3600	Not Applicable
polypeptide	ENSMUSP00000042606	Ensembl \| MGI Sequence Detail	237	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005179 CD99 molecule-like protein 2

(term hierarchy)
InterPro Domains

IPR022078 CD99 antigen-like protein 2
GlyGen

Q8BIF0 4 sites, 1 O-linked glycan (3 sites)

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All nucleic 15

cDNA 13

Primer pair 2

Antibodies 1

Microarray probesets 6

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MGI:2148021

Summaries

All 35

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:361717 Kang M, et al., Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation. Cell Rep. 2025 Jan 28;44(1):115155

TSS for Cd99l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163529	ChrX:70536405-70536466 (-)	19 bp
Tssr163528	ChrX:70536198-70536264 (-)	224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29