Bmf MGI Mouse Gene Detail - MGI:2176433

Symbol

Bmf
Name

BCL2 modifying factor

Feature Type

protein coding gene
IDs

MGI:2176433
NCBI Gene: 171543
Gene Overview

MyGene.info: BMF
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:118528757-118549678 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.40 cM, cytoband E5
Mapping Data

3 experiments

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2176433	protein coding gene	Chr2:118528757-118549687 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026316	protein coding gene	Chr2:121216265-121237042 (-)
A/J	MGP_AJ_G0026277	protein coding gene	Chr2:116300249-116322104 (-)
AKR/J	MGP_AKRJ_G0026256	protein coding gene	Chr2:119560278-119581185 (-)
BALB/cJ	MGP_BALBcJ_G0026290	protein coding gene	Chr2:116555479-116577962 (-)
C3H/HeJ	MGP_C3HHeJ_G0026036	protein coding gene	Chr2:120018737-120040457 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026737	protein coding gene	Chr2:125228579-125251081 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024117	protein coding gene	Chr2:111346848-111367383 (-)
CAST/EiJ	MGP_CASTEiJ_G0025498	protein coding gene	Chr2:120324689-120349088 (-)
CBA/J	MGP_CBAJ_G0026012	protein coding gene	Chr2:129650260-129672196 (-)
DBA/2J	MGP_DBA2J_G0026151	protein coding gene	Chr2:115719853-115741210 (-)
FVB/NJ	MGP_FVBNJ_G0026113	protein coding gene	Chr2:114544972-114568700 (-)
LP/J	MGP_LPJ_G0026252	protein coding gene	Chr2:121542334-121564457 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026132	protein coding gene	Chr2:134016848-134039553 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026792	protein coding gene	Chr2:119681689-119702848 (-)
PWK/PhJ	MGP_PWKPhJ_G0025234	protein coding gene	Chr2:115273416-115294573 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025033	protein coding gene	Chr2:118839455-118864215 (-)
WSB/EiJ	MGP_WSBEiJ_G0025567	protein coding gene	Chr2:120501401-120523225 (-)

Human Ortholog

BMF, Bcl2 modifying factor

Vertebrate Orthologs

9

Human Ortholog

BMF, Bcl2 modifying factor
Orthology source: HomoloGene, HGNC
Links

HGNC:24132

NCBI Gene ID: 90427

neXtProt AC: NX_Q96LC9

UniProt: Q96LC9
Chr Location

15q15.1; chr15:40087890-40108884 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 14130
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: BMF
Gene Tree

Bmf

less

Phenotype Summary

23 phenotypes from 4 alleles in 5 genetic backgrounds
11 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Gene trapped

17
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Bmf
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for targeted knockout mutations show enlarged spleen, increased B cells and CD8-positive T cells, decreased B cells and T cells apoptosis, vagina atresia and hydrometrocolpos.

less

All GO Annotations

28
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

1
cDNA Data

51
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bmf

less

Bmf interacts with 400 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

less

All Sequences

56
RefSeq

9
UniProt

4
CCDS

CCDS16578.1, CCDS79835.1
UniGene

210125

Ensembl

ENSMUSG00000040093 (Evidence)
NCBI Gene

171543

			Length	Strain/Species	Flank
genomic	171543	NCBI Gene Model \| MGI Sequence Detail	20922	C57BL/6J	± kb
transcript	NM_138313	RefSeq \| MGI Sequence Detail	4641	C57BL/6
polypeptide	Q91ZE9	UniProt \| EBI \| MGI Sequence Detail	185	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000004769 Bcl-2-modifying factor

(term hierarchy)
PDB

2VOG
InterPro Domains

IPR028192 Bcl-2-modifying factor

less

All nucleic 51

cDNA 51

Microarray probesets 5

less

MGI:2139336, MGI:2139345

Summaries

All 66

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 28
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:276965 Delbridge ARD, et al., Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects. Cell Rep. 2019 Apr 9;27(2):442-454.e5

TSS for Bmf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25782	Chr2:118549668-118549683 (-)	2 bp
Tssr25781	Chr2:118549625-118549655 (-)	38 bp
Tssr25780	Chr2:118547541-118547567 (-)	2,124 bp
Tssr25779	Chr2:118547018-118547042 (-)	2,648 bp
Tssr25778	Chr2:118545310-118545344 (-)	4,351 bp
Tssr25777	Chr2:118545162-118545169 (-)	4,512 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14