Bmf MGI Mouse Gene Detail - MGI:2176433

Bmf Gene Detail

Symbol

Bmf
Name

BCL2 modifying factor

Feature Type

protein coding gene
IDs

MGI:2176433
NCBI Gene: 171543
Gene Overview

MyGene.info: BMF
Alliance

gene page

Sequence Map

Chr2:118528757-118549687 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

20931 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.40 cM, cytoband E5
Mapping Data

3 experiments

Human Ortholog

BMF, Bcl2 modifying factor

Vertebrate Orthologs

9

Human Ortholog

BMF, Bcl2 modifying factor
Orthology source: HomoloGene, HGNC
Links

HGNC:24132

NCBI Gene ID: 90427

neXtProt AC: NX_Q96LC9

UniProt: Q96LC9
Chr Location

15q15.1; chr15:40087890-40108884 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 14130
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: BMF
Gene Tree

Bmf

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Phenotype Summary

23 phenotypes from 4 alleles in 5 genetic backgrounds
11 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Gene trapped

17
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Bmf
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for targeted knockout mutations show enlarged spleen, increased B cells and CD8-positive T cells, decreased B cells and T cells apoptosis, vagina atresia and hydrometrocolpos.

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All GO Annotations

25
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

1
cDNA Data

50
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bmf

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Bmf interacts with 400 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

49
RefSeq

9
UniProt

4
CCDS

CCDS16578.1, CCDS79835.1
UniGene

210125

			Length	Strain/Species	Flank
genomic	OTTMUSG00000015369	VEGA Gene Model \| MGI Sequence Detail	20931	C57BL/6J	± kb
transcript	OTTMUST00000036427	VEGA \| MGI Sequence Detail	4642	Not Applicable
polypeptide	OTTMUSP00000016372	VEGA \| MGI Sequence Detail	271	Not Applicable

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SNPs within 2kb

153 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000004769 bcl-2-modifying factor

(term hierarchy)
PDB

2VOG
InterPro Domains

IPR028192 Bcl-2-modifying factor

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All nucleic 50

cDNA 50

Microarray probesets 5

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MGI:2139336, MGI:2139345

Summaries

All 60

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 23
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:251837 Girnius N, et al., JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep. 2017 Nov 14;21(7):1910-1921

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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