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Bmf Gene Detail
Summary
  • Symbol
    Bmf
  • Name
    BCL2 modifying factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176433
    NCBI Gene: 171543
  • Gene Overview
    MyGene.info: BMF
Location & Maps
more
  • Sequence Map
    Chr2:118528757-118549687 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20931 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.40 cM, cytoband E5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BMF, Bcl2 modifying factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BMF, Bcl2 modifying factor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 90427
    neXtProt AC: NX_Q96LC9

  • Chr Location
    15q14; chr15:40087890-40108884 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 14130
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: BMF
  • Gene Tree
    Bmf
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Bmf
  • Incidental Mutations
    APF , CvDC
Mice homozygous for targeted knockout mutations show enlarged spleen, increased B cells and CD8-positive T cells, decreased B cells and T cells apoptosis, vagina atresia and hydrometrocolpos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    1
  • cDNA Data
    51
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015369 VEGA Gene Model | MGI Sequence Detail 20931 C57BL/6J ±  kb
transcript OTTMUST00000036427 VEGA | MGI Sequence Detail 4642 Not Applicable  
polypeptide OTTMUSP00000016372 VEGA | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    153 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004769 bcl-2-modifying factor
  • PDB
    2VOG
  • InterPro Domains
    IPR028192 Bcl-2-modifying factor
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139336, MGI:2139345
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:74519 Puthalakath H, et al., Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 2001 Sep 7;293(5536):1829-32
  • Latest
    J:232924 Vaithiyanathan K, et al., BCL2-modifying factor promotes germ cell loss during murine oogenesis. Reproduction. 2016 May;151(5):553-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory