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Bmf Gene Detail
Summary
  • Symbol
    Bmf
  • Name
    BCL2 modifying factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176433
    NCBI Gene: 171543
  • Gene Overview
    MyGene.info: BMF
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:118528757-118549687 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20931 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.40 cM, cytoband E5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BMF, Bcl2 modifying factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BMF, Bcl2 modifying factor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 90427
    neXtProt AC: NX_Q96LC9
    UniProt: Q96LC9

  • Chr Location
    15q15.1; chr15:40087890-40108884 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 14130
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BMF
  • Gene Tree
    Bmf
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted knockout mutations show enlarged spleen, increased B cells and CD8-positive T cells, decreased B cells and T cells apoptosis, vagina atresia and hydrometrocolpos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    1
  • cDNA Data
    51
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015369 VEGA Gene Model | MGI Sequence Detail 20931 C57BL/6J ±  kb
    transcript OTTMUST00000036427 VEGA | MGI Sequence Detail 4642 Not Applicable  
    polypeptide OTTMUSP00000016372 VEGA | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      153 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139336, MGI:2139345
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261461 Fahl SP, et al., c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint. J Immunol. 2018 May 15;200(10):3450-3463
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory