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Grid2ip Gene Detail
Summary
  • Symbol
    Grid2ip
  • Name
    glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
  • Synonyms
    delphilin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176213
    NCBI Gene: 170935
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143357330-143391779 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 82.10 cM, cytoband G2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176213
protein coding gene Chr5:143357330-143392152 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030330
protein coding gene Chr5:148685260-148722107 (+)
A/J MGP_AJ_G0030299
protein coding gene Chr5:142304207-142343796 (+)
AKR/J MGP_AKRJ_G0030231
protein coding gene Chr5:146761316-146795892 (+)
BALB/cJ MGP_BALBcJ_G0030316
protein coding gene Chr5:143554256-143589776 (+)
C3H/HeJ MGP_C3HHeJ_G0030027
protein coding gene Chr5:147576668-147611988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030761
protein coding gene Chr5:154118334-154156387 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027979
protein coding gene Chr5:136083871-136119446 (+)
CAST/EiJ MGP_CASTEiJ_G0029432
protein coding gene Chr5:147070525-147107333 (+)
CBA/J MGP_CBAJ_G0029997
protein coding gene Chr5:160471865-160513221 (+)
DBA/2J MGP_DBA2J_G0030147
protein coding gene Chr5:142073216-142107995 (+)
FVB/NJ MGP_FVBNJ_G0030102
protein coding gene Chr5:141281594-141320079 (+)
LP/J MGP_LPJ_G0030233
protein coding gene Chr5:149288471-149323824 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030133
protein coding gene Chr5:162863901-162908284 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030801
protein coding gene Chr5:146613667-146652513 (+)
PWK/PhJ MGP_PWKPhJ_G0029147
protein coding gene Chr5:141156728-141192445 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028983
protein coding gene Chr5:144350883-144389485 (+)
WSB/EiJ MGP_WSBEiJ_G0029505
protein coding gene Chr5:147402567-147440996 (+)



Homology
more
  • Human Ortholog
    GRID2IP, Grid2 interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRID2IP, Grid2 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DELPHILIN
  • Links
    NCBI Gene ID: 392862
    neXtProt AC: NX_A4D2P6
    UniProt: A4D2P6

  • Chr Location
    chr7:6496778-6551436 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display facilitated long-term depression induction at parallel fiber-Purkinje cell synapses as well as enhanced optokinetic response adaptation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 170935 NCBI Gene Model | MGI Sequence Detail 34450 C57BL/6J ±  kb
transcript NM_001159321 RefSeq | MGI Sequence Detail 4144 C57BL/6  
polypeptide Q0QWG9 UniProt | EBI | MGI Sequence Detail 1203 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:74533 Miyagi Y, et al., Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. J Neurosci. 2002 Feb 1;22(3):803-14
  • Latest
    J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory