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Cyp26b1
Gene Detail
Symbol

Name
ID
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
MGI:2176159
Synonyms
CP26, P450RAI-2, retinoic acid B1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
36.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:84571414-84593908 bp, - strand
From NCBI annotation of GRCm38

  22495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP26B1
Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp26b1

Human
homologs
CYP26B1, cytochrome P450, family 26, subfamily B, polypeptide 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 56603
neXtProt AC: NX_Q9NR63

Human Synonyms: CYP26A2, P450RAI2, P450RAI-2, RHFCA

Human Chr (Location): 2p13.2; chr2:72129238-72147862 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CYP26B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Spontaneous(1) Targeted(10)
Genomic Mutations involving Cyp26b1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Limb morphogenesis and proximal-distal patterning is disrupted in homozygous null fetuses. Mutant mice are born, however they die immediately after birth exhibiting respiratory distress.
 
Interactions
Cyp26b1 interacts with 308 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (73 annotations)
Process bone morphogenesis, cell fate determination, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 1-hydroxypyrene 6,7-monooxygenase activity, 1-hydroxypyrene 7,8-monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (347)    Tissues (243)    Images (88)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 254
Northern blot 1
RT-PCR 92
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CYP26B1 ; Xenbase cyp26b1 ; ZFIN cyp26b1    NEW 
Molecular
reagents
All nucleic(44) cDNA(31) Primer pair(8) Other(5)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000063415 (Evidence)
Entrez Gene 232174 (Evidence)
UniGene 255246
DFCI TC1583864
DoTS DT.110473310, DT.94148264, DT.50316393, DT.96085969
NIA Mouse Gene Index U027544
EC 1.14.-.-
Consensus CDS Project CCDS20289.1
International Mouse Phenotyping Consortium Status Cyp26b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 232174 NCBI Gene Model | MGI Sequence Detail 22495 C57BL/6J ±  kb
transcript NM_175475 RefSeq | MGI Sequence Detail 4751 C57BL/6 
polypeptide Q811W2 UniProt | EBI | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006108 cytochrome P450 26B1
Graphical View of Protein Domain Structure
References
(Earliest) J:71426 MacLean G, et al., Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev. 2001 Sep;107(1-2):195-201
(Latest) J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8
All references(104)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory