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Cyp26b1
Gene Detail
Symbol

Name
ID
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
MGI:2176159
Synonyms
CP26, P450RAI-2, retinoic acid B1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
36.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:84571414-84593908 bp, - strand
From NCBI annotation of GRCm38

  22495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp26b1

Human
homologs
Human Homolog CYP26B1, cytochrome P450, family 26, subfamily B, polypeptide 1
NCBI Gene ID 56603
neXtProt AC  NX_Q9NR63
Human Synonyms  CYP26A2, P450RAI2, P450RAI-2, RHFCA
Human Chr (Location)  2p13.2; chr2:72129238-72147862 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP26B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Limb morphogenesis and proximal-distal patterning is disrupted in homozygous null fetuses. Mutant mice are born, however they die immediately after birth exhibiting respiratory distress.
 
Interactions
Cyp26b1 interacts with 309 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process bone morphogenesis, cell fate determination, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 1-hydroxypyrene 6,7-monooxygenase activity, 1-hydroxypyrene 7,8-monooxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (62 records)
Data Summary: Results (347)    Tissues (239)    Images (88)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 254
Northern blot 1
RT-PCR 92
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(31) Primer pair(8) Other(5)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000063415 (Evidence)
Entrez Gene232174 (Evidence)
UniGene255246
DFCITC1583864
DoTSDT.96085969, DT.94148264, DT.50316393, DT.110473310
NIA Mouse Gene IndexU027544
EC1.14.-.-
Consensus CDS ProjectCCDS20289.1
International Mouse Knockout Project StatusCyp26b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 232174 NCBI Gene Model | MGI Sequence Detail 22495 C57BL/6J ±  kb
transcript NM_175475 RefSeq | MGI Sequence Detail 4751 C57BL/6 
polypeptide Q811W2 UniProt | EBI | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006108 cytochrome P450 26B1
Graphical View of Protein Domain Structure
References
(Earliest) J:71426 MacLean G, et al., Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev. 2001 Sep;107(1-2):195-201
(Latest) J:209131 Saba R, et al., CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014 May 15;389(2):173-81
All references(99)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory