Cyp26b1
Gene Detail

Symbol Name ID

Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 MGI:2176159

Synonyms

CP26, P450RAI-2, retinoic acid B1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

36.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:84571414-84593908 bp, - strand From NCBI annotation of GRCm38   22495 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp26b1

Human homologs

Human Homolog		CYP26B1, cytochrome P450, family 26, subfamily B, polypeptide 1
NCBI Gene ID		56603
neXtProt AC		NX_Q9NR63
Human Synonyms		CYP26A2, P450RAI2, P450RAI-2, RHFCA
Human Chr (Location)		2p13.2; chr2:72356367-72374963 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CYP26B1

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Limb morphogenesis and proximal-distal patterning is disrupted in homozygous null fetuses. Mutant mice are born, however they die immediately after birth exhibiting respiratory distress.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	bone morphogenesis, cell fate determination, ...
Component	endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function	electron carrier activity, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (52 records)
Data Summary: Results (325)    Tissues (224)    Images (77)
Theiler Stages: 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	238
Northern blot	1
RT-PCR	86

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(30) Primer pair(7) Other(3)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000063415 (Evidence)
Entrez Gene	232174 (Evidence)
UniGene	255246
DFCI	TC1583864
DoTS	DT.110473310, DT.50316393, DT.94148264, DT.96085969
NIA Mouse Gene Index	U027544
EC	1.14.-.-
Consensus CDS Project	CCDS20289.1
International Mouse Knockout Project Status	Cyp26b1

Sequences

Length	Strain/Species
genomic	232174	NCBI Gene Model | MGI Sequence Detail	22495	C57BL/6J
transcript	NM_175475	RefSeq | MGI Sequence Detail	4751	C57BL/6
polypeptide	Q811W2	UniProt | EBI | MGI Sequence Detail	512	Not Applicable

All sequences(23) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR017972	Cytochrome P450, conserved site
InterPro	IPR002403	Cytochrome P450, E-class, group IV
Protein Ontology	PR:000006108	cytochrome P450 26B1

Graphical View of Protein Domain Structure

References

(Earliest) J:71426 MacLean G, et al., Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev. 2001 Sep;107(1-2):195-201
(Latest) J:192725 Okano J, et al., Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. J Cell Sci. 2012 Apr 1;125(Pt 7):1827-36
All references(87)