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Arr3
Gene Detail
Symbol

Name
ID
Arr3
arrestin 3, retinal
MGI:2159617
Synonyms
Arr4, arrestin 4, CAR, cone arrestin, mCAR, mCARFL, X-arrestin
Feature Type
protein coding gene
Genetic Map
Chromosome X
43.72 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:100605497-100618493 bp, + strand
From VEGA annotation of GRCm38

  12997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ARR3
Protein SuperFamily: arrestin
Gene Tree: Arr3

Human
homologs
ARR3, arrestin 3, retinal (X-arrestin)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 407
neXtProt AC: NX_P36575

Human Synonyms: ARRX

Human Chr (Location): Xcen-q21; chrX:70263503-70281840 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a null allele exhibit normal cone electrophysiology.
 
Interactions
Arr3 interacts with 82 markers (Mir17, Mir20b, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process endocytosis, regulation of protein phosphorylation, ...
Component photoreceptor inner segment, photoreceptor outer segment, ...
Function opsin binding, phosphoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (4)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ARR3 ; Xenbase arr3 ; ZFIN arr3a, arr3b    NEW 
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018283 (Evidence)
Ensembl Gene Model ENSMUSG00000060890 (Evidence)
Entrez Gene 170735 (Evidence)
UniGene 95518
DFCI TC1589427, TC1592099
DoTS DT.91337931, DT.97407482
NIA Mouse Gene Index U020056
Consensus CDS Project CCDS41075.1
International Mouse Phenotyping Consortium Status Arr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018283 VEGA Gene Model | MGI Sequence Detail 12997 C57BL/6J ±  kb
transcript OTTMUST00000044179 VEGA | MGI Sequence Detail 1359 Not Applicable 
polypeptide OTTMUSP00000019862 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(31) UniProt(3)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000698 Arrestin
InterPro IPR017864 Arrestin, conserved site
InterPro IPR014752 Arrestin, C-terminal
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014753 Arrestin, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000004318 arrestin-C
References
(Earliest) J:61371 Hong DH, et al., A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3649-54
(Latest) J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory