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Mia2
Gene Detail
 Symbol
Name
ID
Mia2
melanoma inhibitory activity 2
MGI:2159614
Feature Type protein coding gene
Genetic Map
Chromosome 12
26.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:59095799-59109130 bp, + strand
From VEGA annotation of GRCm38

  13332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137655  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee

Protein SuperFamily: secreted protein with SH3-like domain
Gene Tree: Mia2

Human
homologs
Human Homolog MIA2, melanoma inhibitory activity 2
NCBI Gene ID 117153
neXtProt AC  NX_Q96PC5
Human Chr (Location)  14q13.2; chr14:39233921-39253371 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit decreased serum levels of cholesterol, HDL cholesterol, triglyceride, and VLDL triglyceride.
 
Interactions
Mia2 interacts with 40 markers (Mir1b, Mir19a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cholesterol homeostasis, triglyceride homeostasis
Component endoplasmic reticulum exit site, extracellular region
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Images (1)
Theiler Stages: 20
Assay TypeResults
RNA in situ 1
RT-PCR 1
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(2) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000027665 (Evidence)
Ensembl Gene ModelENSMUSG00000035349 (Evidence)
Entrez Gene338320 (Evidence)
UniGene213215
DoTSDT.97343041
Consensus CDS ProjectCCDS25934.1
International Mouse Knockout Project StatusMia2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027665 VEGA Gene Model | MGI Sequence Detail 13332 C57BL/6J ±  kb
transcript OTTMUST00000068449 VEGA | MGI Sequence Detail 1629 Not Applicable 
polypeptide OTTMUSP00000034615 VEGA | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000010394 melanoma inhibitory activity protein 2
References (Earliest) J:74659 Moser M, et al., Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. Mol Cell Biol. 2002 Mar;22(5):1438-45
(Latest) J:176259 Pitman JL, et al., Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites. J Lipid Res. 2011 Oct;52(10):1775-86
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory