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Arhgap4 Gene Detail
Summary
  • Symbol
    Arhgap4
  • Name
    Rho GTPase activating protein 4
  • Synonyms
    A130009C12Rik, A530015A20Rik, c1, Rgc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159577
    NCBI Gene: 171207
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72937958-72954945 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159577
 protein coding gene ChrX:72935048-72965476 (-)
129S1/SvImJ ENSMUSG00200042295
 protein coding gene ChrX:54995631-55015530 (-)
A/J ENSMUSG00195033764
 protein coding gene ChrX:58671866-58691767 (-)
AKR/J ENSMUSG00220045921
 protein coding gene ChrX:53974167-53994066 (-)
BALB/cJ ENSMUSG00180047186
 protein coding gene ChrX:55252601-55272500 (-)
C3H/HeJ ENSMUSG00175031738
 protein coding gene ChrX:58836257-58856156 (-)
C57BL/6NJ ENSMUSG00215038504
 protein coding gene ChrX:55336254-55356149 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033164
 protein coding gene ChrX:68899379-68929491 (-)
CAST/EiJ ENSTCUG00005040900
 protein coding gene ChrX:56753902-56773919 (-)
CBA/J ENSMUSG00210037824
 protein coding gene ChrX:55516926-55536826 (-)
DBA/2J ENSMUSG00185033036
 protein coding gene ChrX:67938554-67958453 (-)
FVB/NJ ENSMUSG00205025319
 protein coding gene ChrX:54817905-54837804 (-)
JF1/MsJ ENSUMUG00000026653
 protein coding gene ChrX:88679204-88699159 (-)
LP/J ENSMUSG00230031819
 protein coding gene ChrX:74517768-74537667 (-)
NOD/ShiLtJ ENSMUSG00190030261
 protein coding gene ChrX:54756909-54776810 (-)
NZO/HlLtJ ENSMUSG00225047231
 protein coding gene ChrX:79722163-79742062 (-)
PWK/PhJ ENSLUMG00010038882
 protein coding gene ChrX:54500436-54520351 (-)
SPRET/EiJ ENSMSPG00010031352
 protein coding gene ChrX:57582745-57602774 (-)
WSB/EiJ ENSIUOG00005048633
 protein coding gene ChrX:55584075-55604166 (-)



Homology
more
  • Human Ortholog
    ARHGAP4, Rho GTPase activating protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP4, Rho GTPase activating protein 4
  • Synonyms
    C1, p115, RGC1, RhoGAP4, SrGAP4
  • Links
    NCBI Gene ID: 393
    UniProt: P98171

  • Chr Location
    Xq28; chrX:153907367-153934999 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 171207 NCBI Gene Model | MGI Sequence Detail 16988 C57BL/6J ±  kb
transcript NM_138630 RefSeq | MGI Sequence Detail 3321 C57BL/6  
polypeptide NP_619536 RefSeq | MGI Sequence Detail 955 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
less
MGI:2441775, MGI:2441804
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory