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Arhgap4
Gene Detail
Symbol

Name
ID
Arhgap4
Rho GTPase activating protein 4
MGI:2159577
Synonyms
A130009C12Rik, A530015A20Rik, c1, Rgc1
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:73891442-73921870 bp, - strand
From VEGA annotation of GRCm38

  30429 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20403  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Arhgap4

Human
homologs
Human Homolog ARHGAP4, Rho GTPase activating protein 4
NCBI Gene ID 393
neXtProt AC  NX_P98171
Human Synonyms  C1, p115, RGC1, RhoGAP4, SrGAP4
Human Chr (Location)  Xq28; chrX:153907376-153926260 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Arhgap4 interacts with 298 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of axon extension, negative regulation of fibroblast migration, ...
Component cytoplasm, Golgi apparatus, ...
Function Rho GTPase activator activity
External Resources: FuncBase
Expression
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017679 (Evidence)
Ensembl Gene ModelENSMUSG00000031389 (Evidence)
Entrez Gene171207 (Evidence)
DFCITC1583559, TC1643424, TC1644272, TC1626813, TC1699204
Consensus CDS ProjectCCDS41014.1, CCDS53100.1, CCDS53101.1
International Mouse Knockout Project StatusArhgap4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017679 VEGA Gene Model | MGI Sequence Detail 30429 C57BL/6J ±  kb
transcript OTTMUST00000055037 VEGA | MGI Sequence Detail 6299 Not Applicable 
polypeptide OTTMUSP00000026297 VEGA | MGI Sequence Detail 965 Not Applicable 

For the selected sequences
All sequences(138) RefSeq(16) UniProt(32)
Polymorphisms
SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:182891 Chen XW, et al., A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell. 2011 Jan 1;22(1):141-52
All references(25)
Other
accession IDs
MGI:2441775, MGI:2441804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory